Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular and Cellular Biology

• Publication date

  1999-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.19.6.4065PMID 10330147PMCID PMC104366
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Double Strand Break Repair

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  2005cited by this paper
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  1998cited by this paper
• Sequence-specific Binding of Ku Autoantigen to Single-stranded DNA*

  1998cited by this paper
• DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.

  1998influential reference
• Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle

  1998cited by this paper
• Components of the Ku‐dependent non‐homologous end‐joining pathway are involved in telomeric length maintenance and telomeric silencing

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• Double strand break repair.

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• Interaction of DNA‐dependent protein kinase with DNA and with Ku: biochemical and atomic‐force microscopy studies

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• Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.

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• Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

  1997cited by this paper
• Heat Shock Transcription Factor 1 Binds Selectively in Vitro to Ku Protein and the Catalytic Subunit of the DNA-dependent Protein Kinase*

  1997cited by this paper
• Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

  1997cited by this paper
• Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

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• Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

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• Functions of the DNA dependent protein kinase.

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• Functional Properties of the Separate Subunits of Human DNA Helicase II/Ku Autoantigen*

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• Double‐strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

  1997cited by this paper
• Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates.

  1996cited by this paper
• p95vav associates with the nuclear protein Ku-70

  1996cited by this paper
• Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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• Chromatin structure and the regulation of gene expression: remodeling at the MMTV promoter

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• Morphology, function and pathology of follicular dendritic cells

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• Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

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• The Interaction between Ku Antigen and REF1 Protein Mediates Negative Gene Regulation by Extracellular Calcium (*)

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• Regulation and repair of double-strand DNA breaks.

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• Functional interactions between Stat5 and the glucocorticoid receptor

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• Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86

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• Multi-strand binding of nuclear factors to a repressor of mouse mammary tumor virus transcription can be distinguished kinetically.

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  1995cited by this paper
• Nuclear Factor Binding to a DNA Sequence Element That Represses MMTV Transcription Induces a Structural Transition and Leads to the Contact of Single-Stranded Binding Proteins with DNA

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• DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

  1995cited by this paper
• DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

  1995cited by this paper
• DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

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• DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

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• Mammalian mutants defective in the response to ionizing radiation-induced DNA damage.

  1995cited by this paper
• Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

  1995cited by this paper
• Purification of the sequence‐specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

  1995cited by this paper
• Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer.

  1995cited by this paper
• p95 Associates with the Nuclear Protein Ku-70

  1995cited by this paper
• DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

  1994cited by this paper
• Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.

  1994cited by this paper
• Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

  1994cited by this paper
• The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity.

  1994cited by this paper
• Repression of mouse mammary tumor virus transcription by a transcription factor complex. Binding of individual components to separated DNA strands.

  1994cited by this paper
• The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication.

  1994cited by this paper
• Similar DNA binding properties of free p70 (Ku) subunit and p70/p80 heterodimer

  1994cited by this paper
• Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

  1994cited by this paper
• Production and characterization of recombinant human Ku antigen.

  1994cited by this paper
• Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

  1993cited by this paper
• Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element.

  1993cited by this paper
• EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA.

  1993cited by this paper
• The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.

  1993influential reference
• Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II.

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• Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Human prolactin regulates transfected MMTV LTR‐directed gene expression in a human breast‐carcinoma cell line through synergistic interaction with steroid hormones

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• Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA.

  1992cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991influential reference
• Nuclear factor I acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding.

  1990cited by this paper
• The long terminal repeat region of the mouse mammary tumour virus contains multiple regulatory elements.

  1990cited by this paper
• Extra mouse mammary tumor proviruses in DBA/2 mouse lymphomas acquire a selective advantage in lymphocytes by alteration in the U3 region of the long terminal repeat

  1990influential reference
• Altered mouse mammary tumor virus transcript synthesis in T-cell lymphoma cells

  1990cited by this paper
• Prolactin effects on the dietary regulation of mouse mammary tumor virus proviral DNA expression.

  1990cited by this paper
• Phorbol ester-inducible T-cell-specific expression of variant mouse mammary tumor virus long terminal repeats

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• Gene regulation by steroid hormones.

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• HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex.

  1989influential reference
• Mouse mammary tumor virus proviruses in T-cell lymphomas lack a negative regulatory element in the long terminal repeat

  1988cited by this paper
• Alterations in the U3 region of the long terminal repeat of an infectious thymotropic type B retrovirus

  1988cited by this paper
• Mineralocorticoid regulation of transcription of transfected mouse mammary tumor virus DNA in cultured kidney cells

  1988cited by this paper
• Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin.

  1988cited by this paper
• The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.

  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1987cited by this paper
• Gene regulation by steroid hormones.

  1987cited by this paper
• The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction.

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• Early events in the stimulation of mammary tumor virus RNA synthesis by glucocorticoids. Novel assays of transcription rates.

  1984cited by this paper
• Early Events in the Stimulation of Mammary Tumor Virus RNA Synthesis by Glucocorticoids

  1984cited by this paper
• Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

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• Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action.

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  2007cites this paper
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  2003influential citation
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• Differential DNA Binding of Ku Antigen Determines Its Involvement in DNA Replication

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• Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites

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