Photo-induced chemistry for the design of oligonucleotide conjugates and surfaces.

A photocaged diene is introduced at the 5'-end of oligonucleotides using the H-phosphonate approach. The photoenol-functionalized DNA is subsequently employed for the conjugation to a protein and the spatially controlled immobilization onto surfaces using a light-induced Diels-Alder cycloaddition. Fully functional protein-DNA conjugates and patterned DNA surfaces are obtained under mild irradiation conditions.

• Publication year

  2016

• Venue

  Journal of materials chemistry. B

• Publication date

  2016-01-06

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1039/C5TB02207JPMID 32263208
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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