Airway Epithelial Expression of TLR5 Is Downregulated in Healthy Smokers and Smokers with Chronic Obstructive Pulmonary Disease

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Immunology

• Publication date

  2012-09-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.4049/jimmunol.1101895PMID 22855713PMCID PMC3579667
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution

  2023cited by this paper
• Toll-Like Receptor Signaling Pathways

  2014cited by this paper
• References Subscriptions Permissions Email Alerts Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic

  2013influential reference
• RNA-Seq quantification of the human small airway epithelium transcriptome

  2012cited by this paper
• The Human Airway Epithelial Basal Cell Transcriptome

  2011cited by this paper
• TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T Cell Responses to a Flagellated Pathogen

  2011cited by this paper
• Pseudomonas aeruginosa and Mortality after Hospital Admission for Chronic Obstructive Pulmonary Disease

  2011cited by this paper
• Bacteriological Differences Between COPD Exacerbation and Community-Acquired Pneumonia

  2011cited by this paper
• Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease.

  2011cited by this paper
• Structural biology of the Toll-like receptor family.

  2011cited by this paper
• Interleukin-8 Production by Human Airway Epithelial Cells in Response to Pseudomonas aeruginosa Clinical Isolates Expressing Type a or Type b Flagellins

  2010cited by this paper
• Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals.

  2010cited by this paper
• Innate immune responses of the airway epithelium

  2010cited by this paper
• TLR-4-mediated innate immunity is reduced in cystic fibrosis airway cells.

  2010cited by this paper
• House dust mite regulate the lung inflammation of asthmatic mice through TLR4 pathway in airway epithelial cells

  2010cited by this paper
• [Pseudomonas aeruginosa in chronic obstructive pulmonary disease].

  2010cited by this paper
• Quality control in microarray assessment of gene expression in human airway epithelium

  2009cited by this paper
• Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

  2009cited by this paper
• Pathogen recognition in the innate immune response.

  2009cited by this paper
• Pseudomonas aeruginosa in adults with chronic obstructive pulmonary disease

  2009cited by this paper
• Induction of IL-8 expression by bacterial flagellin is mediated through lipid raft formation and intracellular TLR5 activation in A549 cells.

  2009cited by this paper
• Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin

  2009cited by this paper
• Modification of gene expression of the small airway epithelium in response to cigarette smoking

  2008cited by this paper
• Mapping and quantifying mammalian transcriptomes by RNA-Seq

  2008cited by this paper
• Toll-like receptors — taking an evolutionary approach

  2008cited by this paper
• Pseudomonas aeruginosa in chronic obstructive pulmonary disease.

  2008cited by this paper
• Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

  2007influential reference
• Deletion of TLR5 results in spontaneous colitis in mice.

  2007cited by this paper
• Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction.

  2007cited by this paper
• Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity.

  2007cited by this paper
• Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.

  2007cited by this paper
• Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria

  2006cited by this paper
• Microglia Recognize Double-Stranded RNA via TLR31

  2006cited by this paper
• Pathogen recognition and innate immunity.

  2006cited by this paper
• Oligodeoxynucleotides Differentially Modulate Activation of TLR7 and TLR8 by Imidazoquinolines

  2006cited by this paper
• Modification of gene expression of the small airway epithelium in response to cigarette smoking

  2006cited by this paper
• Human bronchial epithelial cell transcriptome: gene expression changes following acute exposure to whole cigarette smoke in vitro.

  2006cited by this paper
• TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway.

  2005cited by this paper
• Respiratory tract infections: another reason not to smoke.

  2005cited by this paper
• Human Airway Epithelial Cells Sense Pseudomonas aeruginosa Infection via Recognition of Flagellin by Toll-Like Receptor 5

  2005cited by this paper
• Adaptor usage and Toll‐like receptor signaling specificity

  2005cited by this paper
• Cigarette smoking and infection.

  2004cited by this paper
• TLR signaling pathways.

  2004cited by this paper
• Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

  2004cited by this paper
• The road to Toll

  2004cited by this paper
• Innate immunity in the lung: how epithelial cells fight against respiratory pathogens

  2004cited by this paper
• Toll-like receptors in innate immunity.

  2004cited by this paper
• Toll-like receptor signalling

  2004cited by this paper
• Toll-Like Receptor Signaling Pathways

  2003cited by this paper
• Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

  2003cited by this paper
• Toll-like Receptor Signaling*

  2003cited by this paper
• Toll-Like Receptor 4 Mediates Innate Immune Responses to Haemophilus influenzae Infection in Mouse Lung1

  2002cited by this paper
• Decoding the Patterns of Self and Nonself by the Innate Immune System

  2002cited by this paper
• Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary.

  2001cited by this paper
• Liver-Derived IGF-I Regulates GH Secretion at the Pituitary Level in Mice.

  2001cited by this paper
• Toll-like receptors: critical proteins linking innate and acquired immunity

  2001cited by this paper
• Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

  2001cited by this paper
• Liver-derived IGF-I regulates GH secretion at the pituitary level in mice.

  2001cited by this paper
• Lower airway bacterial colonization in asymptomatic smokers and smokers with chronic bronchitis and recurrent exacerbations.

  2000cited by this paper
• Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

  2000cited by this paper
• A Toll-like receptor recognizes bacterial DNA

  2000influential reference
• Unresponsiveness of MyD88-deficient mice to endotoxin.

  1999cited by this paper
• MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.

  1997cited by this paper
• Verteilungsfreie statistische Prüfverfahren

  1984influential reference
• Gene Product Lps the Lipopolysaccharide: Evidence for TLR4 as to (TLR4)-Deficient Mice Are Hyporesponsive Cutting Edge: Toll-Like Receptor 4

  year unknowncited by this paper

• Sequencing and Analysis of Chicken Segmented Filamentous Bacteria Genome Revealed Unique Avian-Specific Features.

  2026cites this paper
• SARS-CoV-2 Spike Protein and Long COVID—Part 2: Understanding the Impact of Spike Protein and Cellular Receptor Interactions on the Pathophysiology of Long COVID Syndrome

  2025cites this paper
• Local tolerance and innate immune activation of primary human respiratory cells exposed to flagellin

  2025cites this paper
• Promoting immune defensive responses of epithelial cells in airway disease

  2025cites this paper
• Enhancing Edwardsiella piscicida Resistance Through CRISPR/Cas9-Mediated Deletion of Toll-like Receptor 5a (tlr5a) in Zebrafish.

  2025cites this paper
• Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

  2024cites this paper
• Immunity and Coagulation in COVID-19

  2024cites this paper
• Recombinant Domain of Flagellin Promotes In Vitro a Chemotactic Inflammatory Profile in Human Immune Cells Independently of a Dendritic Cell Phenotype

  2023cites this paper
• Self-Assembly of Flagellin into Immunostimulatory Ring-like Nanostructures as an Antigen Delivery System.

  2022cites this paper
• Modulation of mouse laryngeal inflammatory and immune cell responses by low and high doses of mainstream cigarette smoke

  2022cites this paper
• Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium

  2022cites this paper
• Comprehensive Assessment of Smoking and Sex Related Effects in Publicly Available Gene Expression Data

  2021cites this paper
• mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

  2021cites this paper
• RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

  2020cites this paper
• ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19

  2020cites this paper
• The Influence of Tobacco Smoke/Nicotine on CYP2A Expression in Human and African Green Monkey Lungs

  2020influential citation
• Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: Implications for SARS-CoV-2 infection

  2020cites this paper
• Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells

  2020cites this paper
• Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19

  2020cites this paper
• Pseudomonas aeruginosa-derived flagellin stimulates IL-6 and IL-8 production in human bronchial epithelial cells: A potential mechanism for progression and exacerbation of COPD

  2019cites this paper
• Tobacco Smoke Induces and Alters Immune Responses in the Lung Triggering Inflammation, Allergy, Asthma and Other Lung Diseases: A Mechanistic Review

  2018cites this paper
• The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology

  2018cites this paper
• TLR7 agonist attenuates acetylcholine‐induced, Ca2+‐dependent ionic currents in swine tracheal submucosal gland cells

  2018cites this paper
• The role of noncoding RNAs in regulating epithelial responses in COPD.

  2018cites this paper
• Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD

  2017cites this paper
• TLR5: beyond the recognition of flagellin

  2017cites this paper
• Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases.

  2017cites this paper
• Are healthy smokers really healthy?

  2016cites this paper
• Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell.

  2016cites this paper
• The innate immune response of large and small airway epithelium to respiratory pathogens in chronic obstructive pulmonary disease

  2016cites this paper
• Hidroxiureia na doença falciforme: influência de polimorfismos nos genes MPO e SERPINA1 e implicações nas vias dos receptores tipo Toll e do Inflamassoma

  2015cites this paper
• SEGEL: A Web Server for Visualization of Smoking Effects on Human Lung Gene Expression

  2015cites this paper
• Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells.

  2014cites this paper
• Caspase-12 Silencing Attenuates Inhibitory Effects of Cigarette Smoke Extract on NOD1 Signaling and hBDs Expression in Human Oral Mucosal Epithelial Cells

  2014influential citation
• The role of MYD88-dependent receptors in the anti-tumor efficacy of the EGFR inhibitor Erlotinib in head and neck cancer

  2014cites this paper
• Epithelial Uptake of Flagella Initiates Proinflammatory Signaling

  2013cites this paper
• Year in review 2012: Asthma and chronic obstructive pulmonary disease

  2013cites this paper