Reduced Frequency of Memory T Cells and Increased Th17 Responses in Patients with Active Tuberculosis

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Clinical and Vaccine Immunology

• Publication date

  2012-08-22

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/CVI.00390-12PMID 22914361PMCID PMC3485891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL‐17 and IFN‐γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease

  2012cited by this paper
• Multifunctional CD4 T Cell Responses in Patients with Active Tuberculosis

  2012cited by this paper
• T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia.

  2012cited by this paper
• Cellular response to mycobacteria: balancing protection and pathology.

  2011cited by this paper
• Regulation of Neutrophils by Interferon-\(\gamma\) Limits Lung Inflammation During Tuberculosis Infection

  2011cited by this paper
• Increased frequencies of T helper type 17 cells in tuberculous pleural effusion.

  2011cited by this paper
• ESAT‐6‐ and CFP‐10‐Specific Th1, Th22 and Th17 Cells in Tuberculous Pleurisy May Contribute to the Local Immune Response Against Mycobacterium Tuberculosis Infection

  2011cited by this paper
• Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

  2011cited by this paper
• Decay Kinetics of an Interferon Gamma Release Assay with Anti-Tuberculosis Therapy in Newly Diagnosed Tuberculosis Cases

  2010cited by this paper
• Preferential infection and depletion of Mycobacterium tuberculosis–specific CD4 T cells after HIV-1 infection

  2010cited by this paper
• Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB.

  2010cited by this paper
• Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis.

  2010cited by this paper
• Characterization of CD4 and CD8 T cells producing IFN-γ in human latent and active tuberculosis.

  2010cited by this paper
• Enumeration of Functional T-Cell Subsets by Fluorescence-Immunospot Defines Signatures of Pathogen Burden in Tuberculosis

  2010cited by this paper
• IL-17 and Th17 cells in tuberculosis.

  2010cited by this paper
• Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis

  2010cited by this paper
• Association of mycobacterial antigen-specific CD4(+) memory T cell subsets with outcome of pulmonary tuberculosis.

  2010influential reference
• Production of TNF-α, IL-12(p40) and IL-17 Can Discriminate between Active TB Disease and Latent Infection in a West African Cohort

  2010cited by this paper
• Variation in Gamma Interferon Responses to Different Infecting Strains of Mycobacterium tuberculosis in Acid-Fast Bacillus Smear-Positive Patients and Household Contacts in Antananarivo, Madagascar

  2010cited by this paper
• Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung

  2010cited by this paper
• PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients

  2010cited by this paper
• Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells.

  2010cited by this paper
• Effector memory T-cells dominate immune responses in tuberculosis treatment: antigen or bacteria persistence?

  2010cited by this paper
• IFNγ Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia

  2009cited by this paper
• Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH-17 cells

  2009cited by this paper
• Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection

  2009cited by this paper
• Cytometric detection of antigen-specific IFN-γ/IL-2 secreting cells in the diagnosis of tuberculosis

  2009cited by this paper
• Mycobacterium tuberculosis-specific CD4+, IFNgamma+, and TNFalpha+ multifunctional memory T cells coexpress GM-CSF.

  2008cited by this paper
• Phenotype and function of human T lymphocyte subsets: Consensus and issues

  2008cited by this paper
• A comparison of IFNgamma detection methods used in tuberculosis vaccine trials.

  2008cited by this paper
• T Cells and Tuberculosis: Beyond Interferon-gamma.

  2008cited by this paper
• Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response1

  2008influential reference
• Immunological Outcomes of New Tuberculosis Vaccine Trials: WHO Panel Recommendations

  2008cited by this paper
• The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis

  2008cited by this paper
• Bacillus Calmette-Guérin Vaccination of Human Newborns Induces T Cells with Complex Cytokine and Phenotypic Profiles1

  2008cited by this paper
• Relationship between whole-blood interferon-gamma responses and the risk of active tuberculosis.

  2008cited by this paper
• Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis1

  2007cited by this paper
• Interleukin-12 and tuberculosis: an old story revisited.

  2007cited by this paper
• IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

  2007cited by this paper
• IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection1

  2007cited by this paper
• Dynamic Relationship between IFN-γ and IL-2 Profile of Mycobacterium tuberculosis-Specific T Cells and Antigen Load1

  2007cited by this paper
• Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes1

  2007cited by this paper
• Phenotypic and functional features of human Th17 cells

  2007cited by this paper
• Discrepancy between Mycobacterium tuberculosis-Specific Gamma Interferon Release Assays Using Short and Prolonged In Vitro Incubation

  2007cited by this paper
• Negative regulation of Th17 responses.

  2007cited by this paper
• Tumor necrosis factor is critical to control tuberculosis infection.

  2007cited by this paper
• CD8 T cell dysfunction during chronic viral infection.

  2007cited by this paper
• Dynamic Relationship between IFN- and IL-2 Profile of Mycobacterium tuberculosis-Specific T Cells and Antigen Load

  2007cited by this paper
• Extended Culture Enhances Sensitivity of a Gamma Interferon Assay for Latent Mycobacterium tuberculosis Infection

  2007cited by this paper
• Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis.

  2006cited by this paper
• An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis

  2006cited by this paper
• Dynamic Changes in Pro- and Anti-Inflammatory Cytokine Profiles and Gamma Interferon Receptor Signaling Integrity Correlate with Tuberculosis Disease Activity and Response to Curative Treatment

  2006cited by this paper
• Understanding the IL-23-IL-17 immune pathway.

  2006cited by this paper
• Cutting Edge: IFN-γ Regulates the Induction and Expansion of IL-17-Producing CD4 T Cells during Mycobacterial Infection1

  2006cited by this paper
• Stepwise Differentiation of CD4 Memory T Cells Defined by Expression of CCR7 and CD271

  2005cited by this paper
• IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available1

  2005cited by this paper
• The success and failure of BCG — implications for a novel tuberculosis vaccine

  2005cited by this paper
• Understanding the generation and function of memory T cell subsets.

  2005cited by this paper
• Central memory and effector memory T cell subsets: function, generation, and maintenance.

  2004cited by this paper
• CD27− CD4+ memory T cells define a differentiated memory population at both the functional and transcriptional levels

  2004cited by this paper
• Interleukin-17 family members and inflammation.

  2004cited by this paper
• Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies.

  2004cited by this paper
• Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection.

  2003cited by this paper
• Identification of non-naïve CD4+CD45RA+ T cell subsets in adult allogeneic haematopoietic cell transplant recipients

  2003cited by this paper
• Tuberculosis subunit vaccine development: on the role of interferon-gamma.

  2001cited by this paper
• CD8+ T Cells Participate in the Memory Immune Response to Mycobacterium tuberculosis

  2001cited by this paper
• Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.

  2001cited by this paper
• Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immunodeficiency Virus Type 1 Variants on Different CD4+-T-Cell Subsets Are Determined Only by Coreceptor Expression

  2001cited by this paper
• CD27 is required for generation and long-term maintenance of T cell immunity

  2000cited by this paper
• Correlates of protective immunity to Mycobacterium tuberculosis in humans.

  2000cited by this paper
• Global tuberculosis control : WHO report

  1997cited by this paper
• Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

  1997cited by this paper
• A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection.

  1996cited by this paper
• Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry.

  1995cited by this paper
• An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection

  1993cited by this paper
• Functional analysis of human T cell subsets defined by CD45 isoform expression.

  1992cited by this paper
• The CD27− subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo

  1992cited by this paper
• Success and Failure

  1988cited by this paper
• Infection Mycobacterium tuberculosis Development of Central Memory during T Cells and the + Antigen-Specific CD8

  year unknowncited by this paper

• IFN-γ and IL-17 elicit synergistic anti-mycobacterial responses by inhibiting coronin-1A retention

  2025cites this paper
• Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases.

  2025cites this paper
• Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases

  2025cites this paper
• The importance of inflammatory biomarkers in detecting and managing latent tuberculosis infection

  2025cites this paper
• The role of the immune response in developing tuberculosis infection: from latent infection to active tuberculosis

  2024cites this paper
• Phenotypic Timeline Kinetics, Integrative Networks, and Performance of T- and B-Cell Subsets Associated with Distinct Clinical Outcome of Severe COVID-19 Patients

  2024cites this paper
• Protective RNA nanovaccines against Mycobacterium avium subspecies hominissuis

  2023cites this paper
• Rhythmic profile of memory T and B-cells along childhood and adolescence

  2023cites this paper
• Diminished Interleukin-7 receptor expression on T-cell subsets in tuberculosis patients.

  2023cites this paper
• CyTOF analysis for differential immune cellular profiling between latent tuberculosis infection and active tuberculosis.

  2023cites this paper
• TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection.

  2021cites this paper
• Detection of Serum Levels of IL-17 and CCL-5 in a Sample of Iraqi Pulmonary Tuberculosis Patients

  2021cites this paper
• Characterizing Early T Cell Responses in Nonhuman Primate Model of Tuberculosis

  2021cites this paper
• Cyto-Feature Engineering: A Pipeline for Flow Cytometry Analysis to Uncover Immune Populations and Associations with Disease

  2020cites this paper
• Multi-parameter flow cytometry immunophenotyping distinguishes different stages of tuberculosis infection.

  2020cites this paper
• Divergent Antigen-Specific Cellular Immune Responses during Asymptomatic Subclinical and Clinical States of Disease in Cows Naturally Infected with Mycobacterium avium subsp. paratuberculosis

  2019cites this paper
• In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5

  2019cites this paper
• Rv2626c and Rv2032 activate TH1 response and downregulate regulatory T cells in peripheral blood mononuclear cells of tuberculosis patients.

  2019cites this paper
• Cell Differentiation Degree as a Factor Determining the Role for Different T-Helper Populations in Tuberculosis Protection

  2019cites this paper
• Metformin Associated Interleukin-10 Affected Insulin Sensitivity and Anti-Tuberculosis Result in Type 2 Diabetes with Tuberculosis Coinfection: A Case Report

  2018cites this paper
• The exhausted CD4+CXCR5+ T cells involve the pathogenesis of human tuberculosis disease.

  2018cites this paper
• Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia

  2018cites this paper
• Potential Immunological Biomarkers for Detection of Mycobacterium tuberculosis Infection in a Setting Where M. tuberculosis Is Endemic, Ethiopia

  2018cites this paper
• Th1, Th17, and Th1Th17 Lymphocytes during Tuberculosis: Th1 Lymphocytes Predominate and Appear as Low-Differentiated CXCR3+CCR6+ Cells in the Blood and Highly Differentiated CXCR3+/−CCR6− Cells in the Lungs

  2018cites this paper
• Potential immunological biomarkers for detection of Mycobacterium tuberculosis infection 1 in endemic setting , Ethiopia

  2018cites this paper
• Assessing and screening for T-cell epitopes from Mycobacterium tuberculosis RD2 proteins for the diagnosis of active tuberculosis

  2018cites this paper
• Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases

  2017cites this paper
• Immunobiology of Pediatric Tuberculosis: Lessons Learned and Implications for an Improved TB-Vaccine

  2017cites this paper
• Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy

  2017cites this paper
• Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis

  2017cites this paper
• Evaluation of profile and functionality of memory T cells in pulmonary tuberculosis.

  2017cites this paper
• Combined Expression of IFN-γ, IL-17, and IL-4 mRNA by Recall PBMCs Moderately Discriminates Active Tuberculosis from Latent Mycobacterium tuberculosis Infection in Patients with Miscellaneous Inflammatory Underlying Conditions

  2016cites this paper
• Dynamics of the T cell response to Mycobacterium tuberculosis DosR and Rpf antigens in a Colombian population of household contacts of recently diagnosed pulmonary tuberculosis patients.

  2016cites this paper
• The Memory Immune Response to Tuberculosis

  2016cites this paper
• Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia

  2016cites this paper
• Restoration of CD4+ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype

  2015cites this paper
• Cytokine Profiles from Antigen-Stimulated Whole-Blood Samples among Patients with Pulmonary or Nonmeningeal Disseminated Coccidioidomycosis

  2015cites this paper
• Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers

  2015cites this paper
• Mycobacterium bovis Infection of Cattle and White-Tailed Deer: Translational Research of Relevance to Human Tuberculosis.

  2015cites this paper
• MiR-155 is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3.

  2015cites this paper
• Phosphorylated STAT3 and PD‐1 regulate IL‐17 production and IL‐23 receptor expression in Mycobacterium tuberculosis infection

  2014cites this paper
• Memory T cell subsets in tuberculosis: what should we be targeting?

  2014cites this paper
• Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB.

  2013cites this paper
• Interferon-γ and interleukin-17 production from PPD-stimulated PBMCss of patients with pulmonary tuberculosis.

  2013cites this paper
• Decreased Expression of miR-21, miR-26a, miR-29a, and miR-142-3p in CD4+ T Cells and Peripheral Blood from Tuberculosis Patients

  2013cites this paper
• INDUCTION OF STRONGER AND LONG LASTING VACCINE IMMUNITY TO TUBERCULOSIS

  2012cites this paper