Breakpoints of t(4;11) translocations in the human MLL and AF4 genes in ALL patients are preferentially clustered outside of high‐affinity matrix attachment regions

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Cellular Biochemistry

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/jcb.1161PMID 11527155
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL

  2001cited by this paper
• DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis.

  2000influential reference
• Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research.

  1999cited by this paper
• A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells

  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998influential reference
• An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region.

  1998cited by this paper
• Complete genomic structure DNA polymorphisms, and alternative splicing of the human AF-6 gene.

  1998cited by this paper
• DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

  1997cited by this paper
• Stress-induced duplex DNA destabilization in scaffold/matrix attachment regions.

  1997cited by this paper
• The structure of the human ALL-1/MLL/HRX gene.

  1997cited by this paper
• Exon/intron structure of the human AF‐4 gene, a member of the AF‐4/LAF‐4/FMR‐2 gene family coding for a nuclear protein with structural alterations in acute leukaemia

  1997cited by this paper
• Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.

  1996cited by this paper
• Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites.

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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11).

  1995cited by this paper
• Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;ll)

  1995cited by this paper
• Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia.

  1994cited by this paper
• Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold.

  1994cited by this paper
• Chromosomal translocations in human cancer

  1994cited by this paper
• The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein.

  1994cited by this paper
• Characterisation of two intronic nuclear-matrix-attachment regions in the human DNA topoisomerase I gene.

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  1994cited by this paper
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  1987cited by this paper
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  1985cited by this paper
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  1984cited by this paper
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  2023cites this paper
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  2021cites this paper
• Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

  2020cites this paper
• Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization

  2018cites this paper
• microRNAs and Acute Myeloid Leukemia Chemoresistance: A Mechanistic Overview

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• Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)—multiple rather than a single mechanism

  2015cites this paper
• Do Non-Genomically Encoded Fusion Transcripts Cause Recurrent Chromosomal Translocations?

  2012cites this paper
• Premature transcript termination, trans-splicing and DNA repair: a vicious path to cancer.

  2011cites this paper
• Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide

  2009influential citation
• PARP-1 expression in the mouse is controlled by an autoregulatory loop: PARP-1 binding to an upstream S/MAR element and to a novel recognition motif in its promoter suppresses transcription.

  2009cites this paper
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  2008cites this paper
• A MLL-KIAA0284 fusion gene in a patient with secondary acute myeloid leukemia and t(11;14)(q23;q32).

  2008cites this paper
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  2006influential citation
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  2006cites this paper
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  2006cites this paper
• Acute lymphoblastic leukemia with 4;11 translocation analyzed by a multi-modal strategy of conventional cytogenetics, FISH, morphology, flow cytometry and molecular genetics, and review of the literature.

  2006cites this paper
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  2003cites this paper