Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Brain research. Developmental brain research

• Publication date

  2003-12-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0165-3806(03)00222-0PMID 14741763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Residential pesticide use during pregnancy among a cohort of urban minority women.

  2002cited by this paper
• Overexpression of α7 nicotinic acetylcholine receptor prevents G1‐arrest and DNA fragmentation in PC12 cells after hypoxia

  2002cited by this paper
• Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?

  2002cited by this paper
• Maternal smoking during pregnancy and severe antisocial behavior in offspring: a review.

  2002cited by this paper
• Temporal association of children's pesticide exposure and agricultural spraying: report of a longitudinal biological monitoring study.

  2002cited by this paper
• Functional Nicotinic Acetylcholine Receptor Expression on Stem and Progenitor Cells of the Early Embryonic Nervous System

  2002cited by this paper
• Nicotine and the adolescent brain: insights from an animal model.

  2002cited by this paper
• The effects of tobacco exposure on children's behavioral and cognitive functioning: implications for clinical and public health policy and future research.

  2002cited by this paper
• Smoking during Pregnancy: A Way to Transfer the Addiction to the Next Generation?

  2002cited by this paper
• Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations.

  2002cited by this paper
• Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus

  2002cited by this paper
• Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children.

  2002cited by this paper
• American Academy of Pediatrics: Tobacco's toll: implications for the pediatrician.

  2001cited by this paper
• Effect of nicotine on cerebellar granule neuron development

  2001cited by this paper
• Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells

  2001cited by this paper
• Functional nicotinic acetylcholine receptor expression in stem and progenitor cells of the early embryonic mouse cerebral cortex.

  2001cited by this paper
• Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.

  2001cited by this paper
• Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.

  2001cited by this paper
• Measurement of children's exposure to pesticides: analysis of urinary metabolite levels in a probability-based sample.

  2001cited by this paper
• Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures.

  2000cited by this paper
• Vulnerable processes of nervous system development: a review of markers and methods.

  2000cited by this paper
• Intergenerational health consequences of maternal smoking

  2000cited by this paper
• Central nicotinic receptors, neurotrophic factors and neuroprotection.

  2000cited by this paper
• alpha7 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells.

  2000cited by this paper
• Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation.

  2000cited by this paper
• Protective effect of nicotine through nicotinic acetylcholine receptor alpha 7 on hypoxia-induced membrane disintegration and DNA fragmentation of cultured PC12 cells.

  2000cited by this paper
• Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus.

  2000cited by this paper
• Effects of alcohol and nicotine on developing olfactory bulb: loss of mitral cells and alterations in neurotransmitter levels.

  1999cited by this paper
• Organophosphorus pesticides: do they all have the same mechanism of toxicity?

  1999cited by this paper
• Developmental cholinotoxicants: nicotine and chlorpyrifos.

  1999cited by this paper
• Morphogenetic roles of acetylcholine.

  1999cited by this paper
• Nicotinic Receptor-Induced Apoptotic Cell Death of Hippocampal Progenitor Cells

  1998cited by this paper
• Nicotine evokes cell death in embryonic rat brain during neurulation.

  1998cited by this paper
• Fetal nicotine or cocaine exposure: which one is worse?

  1998cited by this paper
• Effects of gestational nicotine exposure on hippocampal morphology.

  1998cited by this paper
• Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration.

  1998cited by this paper
• Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.

  1998cited by this paper
• Cholinergic regulation of cortical development and plasticity. New twists to an old story.

  1998cited by this paper
• Nicotine Prevents Experimental Parkinsonism in Rodents and Induces Striatal Increase of Neurotrophic Factors

  1998cited by this paper
• Handbook of Developmental Neurotoxicology

  1998cited by this paper
• Chapter 34 – Developmental Neurotoxicity of Nicotine

  1998cited by this paper
• Passive smoking and sudden infant death syndrome: review of the epidemiological evidence.

  1997cited by this paper
• Cell Biology: A Laboratory Handbook

  1997cited by this paper
• Developmental neurotoxicity of chlorpyrifos: cellular mechanisms.

  1995cited by this paper
• Overexpression of choline acetyltransferase reconstitutes discrete acetylcholine release in some but not all synapse formation-defective neuroblastoma cells.

  1995cited by this paper
• Prenatal exposure to marihuana and tobacco during infancy, early and middle childhood: effects and an attempt at synthesis.

  1995cited by this paper
• Effect of maternal cigarette smoking on pregnancy complications and sudden infant death syndrome.

  1995cited by this paper
• Nicotine stimulation of nerve growth factor receptor expression.

  1994cited by this paper
• A role for the nicotinic alpha-bungarotoxin receptor in neurite outgrowth in PC12 cells.

  1993cited by this paper
• A role for the nicotinic α-bungarotoxin receptor in neurite outgrowth in PC12 cells

  1993cited by this paper
• Maternal substance abuse and the developing nervous system

  1992cited by this paper
• Nerve growth factor enhances [3H]nicotine binding to a nicotinic cholinergic receptor on PC 12 cells.

  1992cited by this paper
• 6 – Prenatal Exposure to Nicotine: What Can We Learn from Animal Models?

  1992cited by this paper
• Inhibition of DNA synthesis in neonatal rat brain regions caused by acute nicotine administration.

  1991cited by this paper
• Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

  1989cited by this paper
• Regulation of the differentiation of PC12 pheochromocytoma cells.

  1989cited by this paper
• Stimulation of neuronal acetylcholine receptors induces rapid gene transcription.

  1986cited by this paper
• Effects of α-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: Critical perinatal periods for regional selectivity

  1986cited by this paper
• Nerve growth factor treatment enhances nicotine-stimulated dopamine release and increases in cyclic adenosine 3':5'-monophosphate levels in PC12 cell cultures

  1985cited by this paper
• Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.

  1984cited by this paper
• STATISTICAL METHODS

  1967cited by this paper

• Pre-validation of an alternative test method for prediction of developmental neurotoxicity.

  2022cites this paper
• Evaluation of genetic damage in pesticides applicators from the province of Córdoba, Argentina

  2019cites this paper
• Exposition prénatale aux pesticides organophosphorés et neurodéveloppement chez les jeunes enfants

  2019cites this paper
• Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together.

  2018cites this paper
• Trigonelline Ameliorates Learning and Memory and Synaptic Plasticity Impairment in Intrahippocampal Amyloid Beta (1-40) Rat Model of Alzheimer’s Disease

  2018influential citation
• Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells.

  2017influential citation
• Tobacco Smoke and Nicotine

  2017cites this paper
• Retinoic acid exacerbates chlorpyrifos action in ensuing adipogenic differentiation of C3H10T½ cells in a GSK3β dependent pathway

  2017cites this paper
• In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells.

  2017cites this paper
• Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population

  2016cites this paper
• Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex

  2016cites this paper
• Impact of prenatal nicotine on the structure of midbrain dopamine regions in the rat

  2016cites this paper
• Pesticide exposure during pregnancy, like nicotine, affects the brainstem α7 nicotinic acetylcholine receptor expression, increasing the risk of sudden unexplained perinatal death.

  2015cites this paper
• renatal nicotine changes the response to postnatal chlorpyrifos : nteractions targeting serotonergic synaptic function and cognition

  2015cites this paper
• Prenatal nicotine alters the developmental neurotoxicity of postnatal chlorpyrifos directed toward cholinergic systems: better, worse, or just "different?".

  2015influential citation
• Microchannel-connected SU-8 honeycombs by single-step projection photolithography for positioning cells on silicon oxide nanopillar arrays

  2015cites this paper
• Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.

  2015cites this paper
• Connexin 43 mediates PFOS-induced apoptosis in astrocytes.

  2015cites this paper
• Prenatal drug exposures sensitize noradrenergic circuits to subsequent disruption by chlorpyrifos.

  2015cites this paper
• Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene.

  2014cites this paper
• Genotoxicidad de tres plaguicidas utilizados en la actividad bananera de Costa Rica

  2014cites this paper
• Drug Abuse Neurotoxicity: Alcohol and Nicotine as Developmental Stressors

  2014cites this paper
• Genotoxic effects of commercial formulations of Chlorpyrifos and Tebuconazole on green algae

  2014cites this paper
• Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice

  2013cites this paper
• How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways

  2013cites this paper
• Adverse Benzo[a]pyrene Effects on Neurodifferentiation Are Altered by Other Neurotoxicant Coexposures: Interactions with Dexamethasone, Chlorpyrifos, or Nicotine in PC12 Cells

  2013influential citation
• BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.

  2013cites this paper
• Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.

  2012cites this paper
• Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.

  2012cites this paper
• Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells.

  2012cites this paper
• Effects of pre- and neonatal nicotine exposure in rodents: inconsistent evidence.

  2011cites this paper
• Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.

  2011cites this paper
• Gestational nicotine treatment modulates cell death/survival-related pathways in the brains of adolescent female rats.

  2011cites this paper
• Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.

  2011cites this paper
• Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.

  2010cites this paper
• Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.

  2010cites this paper
• Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.

  2010cites this paper
• Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model.

  2010cites this paper
• Adenylyl Cyclase Cell Signaling as a Target and Underlying Mechanism for Persistent Effects of Early-Life Organophosphate Exposure

  2010influential citation
• Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss.

  2010cites this paper
• Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.

  2010cites this paper
• Developmental Neurotoxicity of Silver and Silver Nanoparticles Modeled In Vitro and In Vivo

  2010influential citation
• Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.

  2009cites this paper
• Silver Impairs Neurodevelopment: Studies in PC12 Cells

  2009cites this paper
• Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.

  2009cites this paper
• Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.

  2009influential citation
• Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.

  2009cites this paper
• Oxidative and Excitatory Mechanisms of Developmental Neurotoxicity: Transcriptional Profiles for Chlorpyrifos, Diazinon, Dieldrin, and Divalent Nickel in PC12 Cells

  2008cites this paper
• Ultraviolet Photolysis of Chlorpyrifos: Developmental Neurotoxicity Modeled in PC12 Cells

  2008cites this paper
• Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.

  2008influential citation
• Developmental Neurotoxicity of Perfluorinated Chemicals Modeled in Vitro

  2008influential citation
• Tobacco-induced neurotoxicity of adolescent cognitive development (TINACD): a proposed model for the development of impulsivity in nicotine dependence.

  2008cites this paper
• Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.

  2008cites this paper
• The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine.

  2007cites this paper
• Ameliorating the Developmental Neurotoxicity of Chlorpyrifos: A Mechanisms-Based Approach in PC12 Cells

  2007influential citation
• Duke University Dissertation Template

  2007cites this paper
• Developmental Neurotoxicity of Organophosphates: A Case Study of Chlorpyrifos

  2006cites this paper
• Screening for Developmental Neurotoxicity Using PC12 Cells: Comparisons of Organophosphates with a Carbamate, an Organochlorine, and Divalent Nickel

  2006influential citation
• The interactive effect of alcohol and nicotine on NGF-treated pheochromocytoma cells.

  2006cites this paper
• Chlorpyrifos Affects Phenotypic Outcomes in a Model of Mammalian Neurodevelopment: Critical Stages Targeting Differentiation in PC12 Cells

  2005cites this paper
• Mode of Action: Disruption of Brain Cell Replication, Second Messenger, and Neurotransmitter Systems During Development Leading to Cognitive Dysfunction—Developmental Neurotoxicity of Nicotine

  2005cites this paper
• Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos.

  2005cites this paper
• Cholinergic receptors in human prenetal brain : Presence, distribution and influence of nicotine and ethanol

  2005cites this paper
• Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells.

  2005cites this paper
• [Genotoxicity of three pesticides used in Costa Rican banana plantations].

  2004cites this paper
• Nonenzymatic Functions of Acetylcholinesterase Splice Variants in the Developmental Neurotoxicity of Organophosphates: Chlorpyrifos, Chlorpyrifos Oxon, and Diazinon

  2004cites this paper