Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we summarize our studies evaluating nose-to-brain delivery of drugs and small interfering ribonucleic acids in combination with cell-penetrating peptide-modified polymer micelles. Our findings show that the use of polymer micelles with surface modification with Tat peptide in the intranasal administration enables the non-invasive delivery of therapeutic agents to the brain by increasing the transfer of the administered drug or small interfering ribonucleic acid to the central nervous system from the nasal cavity.

• Publication year

  2015

• Venue

  Medical devices

• Publication date

  2015-01-06

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.2147/MDER.S70856PMID 25610007PMCID 4294762
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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