Oxidative metabolism by P450 and function coupling to efflux systems: Modulation of mycotoxin toxicity

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Food Additives and Contaminants

• Publication date

  2005-04-01

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1080/02652030500073287PMID 16019806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolism of cyclosporine by cytochromes P450 3A9 and 3A4

  2010cited by this paper
• Synthetic studies of roquefortine C: synthesis of isoroquefortine C and a heterocycle.

  2004cited by this paper
• Antioxidant Role of Glutathione S-Transferases: Protection Against Oxidant Toxicity and Regulation of Stress-Mediated Apoptosis

  2004cited by this paper
• A Review on Current Situation of Toxigenic Fungi and Mycotoxins Formation in Turkey

  2004cited by this paper
• Alcohol, Oxidative Stress, and Free Radical Damage

  2003cited by this paper
• Acetaminophen-induced hepatotoxicity.

  2003cited by this paper
• The effects of fruit juices on drug disposition: a new model for drug interactions

  2003cited by this paper
• Biomarkers of lipid peroxidation, airway inflammation and asthma

  2003cited by this paper
• Regulation of Drug and Bile Salt Transporters in Liver and Intestine

  2003cited by this paper
• Increased oxidative stress and altered levels of antioxidants in asthma.

  2003cited by this paper
• Verapamil metabolites: potential P-glycoprotein-mediated multidrug resistance reversal agents.

  2003cited by this paper
• Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions.

  2003cited by this paper
• Chromosomal DNA fragmentation in apoptosis and necrosis induced by oxidative stress.

  2003cited by this paper
• A human drug metabolism database: potential roles in the quantitative predictions of drug metabolism and metabolism-related drug-drug interactions.

  2003cited by this paper
• Mycotoxins

  2003cited by this paper
• Structure and mechanism of ABC transporters.

  2002cited by this paper
• Ipso-substitution by cytochrome P450 with conversion of p-hydroxybenzene derivatives to hydroquinone: evidence for hydroperoxo-iron as the active oxygen species.

  2002cited by this paper
• Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

  2002cited by this paper
• Characterization of two pharmacophores on the multidrug transporter P-glycoprotein.

  2002cited by this paper
• Cyclosporine A regulate oxidative stress‐induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70

  2002cited by this paper
• Oxidants, antioxidants and carcinogenesis.

  2002cited by this paper
• Antioxidant and Pro-oxidant Effect of the Thiolic Compounds N -acetyl- l -cysteine and Glutathione against Free Radical-induced Lipid Peroxidation

  2002cited by this paper
• Total synthesis of isoroquefortine C.

  2002cited by this paper
• Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

  2001cited by this paper
• Molecular requirements for inhibition of cytochrome p450 activities by roquefortine.

  2001cited by this paper
• Modifications of proteins by polyunsaturated fatty acid peroxidation products.

  2000cited by this paper
• Does cyclosporin A generate free radicals?

  2000cited by this paper
• Modulation of oral bioavailability of anticancer drugs: from mouse to man.

  2000cited by this paper
• Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology.

  2000cited by this paper
• Elucidation of distinct ligand binding sites for cytochrome P450 3A4.

  2000cited by this paper
• Biochemical, cellular, and pharmacological aspects of the multidrug transporter.

  1999cited by this paper
• Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance.

  1999cited by this paper
• Biotransformation and Fate of Mycotoxins

  1999cited by this paper
• Stable markers of oxidant damage to proteins and their application in the study of human disease.

  1999cited by this paper
• Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms.

  1998influential reference
• Presence of dopa and amino acid hydroperoxides in proteins modified with advanced glycation end products (AGEs): amino acid oxidation products as a possible source of oxidative stress induced by AGE proteins.

  1998cited by this paper
• Bromocriptine modulates P-glycoprotein function.

  1998cited by this paper
• Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

  1997cited by this paper
• [Tentoxin: structure-activity relationship. Application to the study of its action on chloroplast ATP-synthase].

  1997cited by this paper
• Biochemistry and pathology of radical-mediated protein oxidation.

  1997cited by this paper
• Tentoxine : relations structure-fonction. Application à l'étude de son action sur l'ATP-synthase chloroplastique

  1997cited by this paper
• Differential response of oxygen radical metabolism in rat heart, liver and kidney to cyclosporine A treatment

  1997cited by this paper
• Molecular Interactions of Cyclosporin A with P-glycoprotein

  1997cited by this paper
• The physiological function of drug-transporting P-glycoproteins.

  1997cited by this paper
• Genetic and environmental factors associated with variation of human xenobiotic glucuronidation and sulfation.

  1997cited by this paper
• Membrane fluidity of blood cells.

  1996cited by this paper
• Hepatotoxicity and -carcinogenicity of the fumonisins in rats. A review regarding mechanistic implications for establishing risk in humans.

  1996cited by this paper
• Cytochrome P450: Structure, mechanism, and biochemistry

  1996cited by this paper
• Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

  1995cited by this paper
• Cyclosporins from Tolypocladium terricola.

  1995cited by this paper
• Macrolide Antibacterials

  1995cited by this paper
• Comparative evaluation of the predictive power of calculation procedures for molecular lipophilicity.

  1995influential reference
• Lipid peroxidation and antioxidants as biomarkers of tissue damage.

  1995cited by this paper
• Cyclosporin analogs modified in the 3,7,8-positions: substituent effects on peptidylprolyl isomerase inhibition and immunosuppressive activity are nonadditive.

  1995cited by this paper
• Genotoxicity of zearalenone, an estrogenic mycotoxin: DNA adduct formation in female mouse tissues.

  1995cited by this paper
• Cyclosporine: mechanisms of action and toxicity.

  1994cited by this paper
• Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes.

  1993cited by this paper
• [Critical analysis of drug interactions with cyclosporine. Evaluation of interactions with cyclosporine].

  1992cited by this paper
• Membrane fluidity, reactive oxygen species, and cell-mediated immunity: implications in nutrition and disease.

  1992cited by this paper
• Metabolic activation of carcinogens.

  1992cited by this paper
• Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines.

  1992cited by this paper
• [Cyclosporin A: drug interactions].

  1991cited by this paper
• Isolation of Roquefortine C from Feed Grain

  1990cited by this paper
• Immunosuppressive activity of cyclosporine metabolites compared and characterized by mass spectroscopy and nuclear magnetic resonance.

  1990cited by this paper
• Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

  1990cited by this paper
• Metabolism of dihydroergotamine by a cytochrome P-450 similar to that involved in the metabolism of macrolide antibiotics.

  1989cited by this paper
• Metabolic activation of carcinogens.

  1987cited by this paper
• Excretion of deoxynivalenol and its metabolite in milk, urine, and feces of lactating dairy cows.

  1986cited by this paper
• Pharmacokinetic Interactions of the Macrolide Antibiotics

  1985cited by this paper
• Antimicrobial action of roquefortine

  1979cited by this paper
• Acute toxicity studies on roquefortine and PR toxin, metabolites of Penicillium roqueforti, in the mouse.

  1978cited by this paper
• Degradation of Ochratoxin A by a Ruminant

  1976cited by this paper
• Penicillium roquefortiの培養からfestuclavineおよび3種の新インドール・アルカロイドroquefortine A, BおよびCの分離

  1975cited by this paper
• Mycotoxins

  1975cited by this paper
• Isolation of Festuclavine and Three New Indole Alkaloids, Roquefortine A, B and C from the Cultures of Penicillium roqueforti

  1975cited by this paper
• Principles of Drug Action: The Basis of Pharmacology

  1968cited by this paper

• Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase

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  2022cites this paper
• Biosynthesis of pyrroloindoline-containing natural products.

  2022cites this paper
• Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.

  2018cites this paper
• Antineoplastic potential of mycotoxins.

  2018cites this paper
• 2,5-diketopiperazines in food and beverages: Taste and bioactivity

  2017cites this paper
• Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites

  2017cites this paper
• Database on the taxonomical characterisation and potential toxigenic capacities of microorganisms used for the industrial production of food enzymes and feed additives, which do not have a recommendation for Qualified Presumption of Safety

  2017cites this paper
• OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30.

  2016cites this paper
• A mycotoxin-dedicated total diet study in the Netherlands in 2013: Part III – exposure and risk assessment

  2016cites this paper
• Joining Forces: Fermentation and Organic Synthesis for the Production of Complex Heterocycles.

  2016cites this paper
• A mycotoxin-dedicated total diet study in the Netherlands in 2013: Part I – Design

  2016cites this paper
• Identification and characterization of tumour initiating cells from gynaecological malignancies

  2011cites this paper
• The total synthesis of roquefortine C and a rationale for the thermodynamic stability of isoroquefortine C over roquefortine C.

  2008cites this paper
• Caracterização bioquimica e molecular da doença vassoura-de-bruxa do cacaueiro (Theobroma cacao L.), causada pelo fungo Crinipellis perniciosa

  2006cites this paper