SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis

Yoshida et al. show that mitotic SUMOylation of TOP2A C-terminal domain promotes its association with phosphorylated Haspin kinase through Haspin’s SUMO-interacting motifs to regulate recruitment of Aurora B kinase at mitotic centromeres.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-06-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201511079PMID 27325792PMCID 4915188
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SUMOylation Regulates Polo-like Kinase 1-interacting Checkpoint Helicase (PICH) during Mitosis*

  2015cited by this paper
• SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin

  2015cited by this paper
• Polo‐like kinase‐1 triggers histone phosphorylation by Haspin in mitosis

  2014cited by this paper
• Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres

  2013cited by this paper
• Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis.

  2013cited by this paper
• Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation

  2013cited by this paper
• The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

  2012cited by this paper
• A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.

  2011cited by this paper
• Phosphorylation at serine 331 is required for Aurora B activation

  2011cited by this paper
• Structural basis for the recognition of phosphorylated histone h3 by the survivin subunit of the chromosomal passenger complex.

  2011cited by this paper
• PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes*

  2010cited by this paper
• Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.

  2010cited by this paper
• Rod/Zw10 Complex Is Required for PIASy-dependent Centromeric SUMOylation*

  2010cited by this paper
• Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

  2010cited by this paper
• Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

  2010cited by this paper
• Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

  2010influential reference
• PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

  2010cited by this paper
• Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

  2010cited by this paper
• DNA topoisomerase II and its growing repertoire of biological functions

  2009cited by this paper
• Analysis of SUMOylation of topoisomerase IIalpha with Xenopus egg extracts.

  2009cited by this paper
• Topoisomerase IIα controls the decatenation checkpoint

  2009cited by this paper
• Phospho-regulated SUMO interaction modules connect the SUMO system to CK2 signaling.

  2009cited by this paper
• Dual Role of Topoisomerase II in Centromere Resolution and Aurora B Activity

  2008cited by this paper
• Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity.

  2008cited by this paper
• Specification of SUMO1- and SUMO2-interacting Motifs*

  2006cited by this paper
• The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores

  2006cited by this paper
• Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors.

  2006cited by this paper
• Specification of SUMO 1-and SUMO 2-interacting Motifs *

  2006cited by this paper
• SUMOsp: a web server for sumoylation site prediction

  2006cited by this paper
• The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.

  2006cited by this paper
• NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.

  2006cited by this paper
• Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.

  2006cited by this paper
• Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts

  2005cited by this paper
• PIASy mediates SUMO‐2 conjugation of Topoisomerase‐II on mitotic chromosomes

  2005cited by this paper
• Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif

  2005cited by this paper
• The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

  2005cited by this paper
• SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies.

  2005cited by this paper
• Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity.

  2004cited by this paper
• Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

  2004cited by this paper
• DNA Topoisomerase II Is Required at the Time of Mitosis in Yeast

  2004cited by this paper
• Identification of a SUMO-binding motif that recognizes SUMO-modified proteins.

  2004cited by this paper
• The Ran GTPase regulates kinetochore function.

  2003cited by this paper
• SUMO-2/3 regulates topoisomerase II in mitosis

  2003cited by this paper
• The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.

  2002cited by this paper
• Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae.

  2001cited by this paper
• Analysis of Apoptosis Using Xenopus Egg Extracts

  2001cited by this paper
• Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.

  2000cited by this paper
• INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.

  2000cited by this paper
• SUMO-1 Conjugation to Human DNA Topoisomerase II Isozymes*

  2000cited by this paper
• Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts.

  2000cited by this paper
• Characterization of a Fission Yeast SUMO-1 Homologue, Pmt3p, Required for Multiple Nuclear Events, Including the Control of Telomere Length and Chromosome Segregation

  1999cited by this paper
• Chapter 30 Cell Cycle Extracts

  1991cited by this paper
• Cell cycle extracts.

  1991cited by this paper
• A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes.

  1985cited by this paper
• DNA topoisomerase II is required at the time of mitosis in yeast.

  1985cited by this paper
• Functional contribution of Pds 5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts

  year unknowncited by this paper

• Cellular strategies for repairing trapped protein-DNA complexes.

  2026cites this paper
• Lead-induced Hepatotoxicity in Rat Hepatocytes: a Transcriptomic Network Analysis Reveals Key Molecular Insights.

  2025cites this paper
• Histone H3 N-Terminal Tail Residues Important for Meiosis in Saccharomyces cerevisiae

  2025cites this paper
• PICH impacts the spindle assembly checkpoint via its DNA translocase and SUMO-interaction activities

  2025cites this paper
• Histone H3 tail modifications required for meiosis in Saccharomyces cerevisiae

  2024cites this paper
• Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation

  2023cites this paper
• Cell cycle responses to Topoisomerase II inhibition: Molecular mechanisms and clinical implications

  2023cites this paper
• Low tension recruits the yeast Aurora B protein Ipl1 to centromeres in metaphase

  2023cites this paper
• Super-resolution microscopy reveals the number and distribution of topoisomerase IIα and CENH3 molecules within barley metaphase chromosomes

  2023cites this paper
• SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases

  2022cites this paper
• Roles and regulation of Haspin kinase and its impact on carcinogenesis.

  2022cites this paper
• DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function

  2022cites this paper
• Function and inhibition of Haspin kinase: targeting multiple cancer therapies by antimitosis.

  2022cites this paper
• Role of Aurora B and Haspin kinases in the metaphase Topoisomerase II checkpoint

  2021cites this paper
• Mitotic chromosomes

  2021cites this paper
• Regulation of topoisomerase II stability and activity by ubiquitination and SUMOylation: clinical implications for cancer chemotherapy

  2021cites this paper
• SUMOylation Is Associated with Aggressive Behavior in Chondrosarcoma of Bone

  2021cites this paper
• Anaphase Bridges: Not All Natural Fibers

  2020cites this paper
• Reviewing the Modification, Interactions, and Regulation of the C-TerminalDomain of Topoisomerase IIα as a Prospect for Future Therapeutic Targeting

  2020cites this paper
• Priming chromatin for segregation: functional roles of mitotic histone modifications

  2020cites this paper
• PICH function is required for organization of SUMOylated proteins on mitotic chromosomes

  2020cites this paper
• Haspin regulates Ras localization to promote Cdc24-driven mitotic depolarization

  2020cites this paper
• PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes

  2020cites this paper
• Anaphase Bridges: Not All Natural Fibers Are Healthy

  2020cites this paper
• Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases

  2019cites this paper
• The Impact of the C-Terminal Region on the Interaction of Topoisomerase II Alpha with Mitotic Chromatin

  2019cites this paper
• Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.

  2019cites this paper
• PICH promotes SUMOylated TopoisomeraseIIα dissociation from mitotic centromeres for proper chromosome segregation

  2019cites this paper
• Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II

  2019cites this paper
• Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability

  2019cites this paper
• SUMO targets the APC/C to regulate transition from metaphase to anaphase

  2018cites this paper
• Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere

  2018cites this paper
• Dynamic SUMO remodeling drives a series of critical events during the meiotic divisions in Caenorhabditis elegans

  2018cites this paper
• Guiding Mitotic Progression by Crosstalk between Post-translational Modifications.

  2018cites this paper
• Regulated Recruitment of the Chromosomal Passenger Complex to Chromatin and Microtubules Promotes Accurate Cell Division

  2017cites this paper
• Étude de l'extension N-terminale de la kinase mitotique MPS1

  2017influential citation
• The Mitotic Protein Kinase Haspin and Its Inhibitors

  2017cites this paper
• A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC.

  2017cites this paper
• The Ins and Outs of Aurora B Inner Centromere Localization

  2017influential citation
• Effects of Crosstalks Between Sumoylation and Phosphorylation in Normal Cellular Physiology and Human Diseases.

  2017cites this paper
• Non-Catalytic Roles of the Topoisomerase IIα C-Terminal Domain

  2017cites this paper
• Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

  2017cites this paper
• Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.

  2017cites this paper
• Playing polo during mitosis: PLK1 takes the lead

  2017cites this paper
• Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function

  2017cites this paper
• Myeloperoxidase enhances DNA damage induced by drugs targeting DNA topoisomerase II

  2017cites this paper
• Studies Of Sumoylation In Regulating Mif Stability And Rangap1 Nucleo-Cytoplasmic Shuttling In Controlling Its Sumo Modification

  2017influential citation
• Chromatin determinants of the inner-centromere rely on replication factors with functions that impart cohesion

  2016cites this paper
• A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis

  2016cites this paper
• Untangling Topo II’s function at mitotic centromeres

  2016cites this paper
• Mechanisms behind Topoisomerase II SUMOylation in chromosome segregation

  2016cites this paper
• Functional Roles of Protein Arginine Methyltransferase 5 in Cardiovascular Diseases

  2016cites this paper
• 1 DNA-Stimulated Liquid-Liquid Phase Separation by Eukaryotic Topoisomerase II Modulates 1 Catalytic Function 2 3

  year unknowncites this paper