SCIENCE@home

Riluzole Ameliorates Harmaline-induced Tremor in Rat

Fatemeh Rahimi Shourmasti,I. Goudarzi,K. Abrari,M. E. Salmani,Taghi Laskarbolouki

Published 2014 in Basic and Clinical Neuroscience

ABSTRACT

Introduction Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat. Methods Four groups of Wistar rats weighing 80–100 g were injected with harmaline (30 mg/ kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/ kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded. Results The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor. Discussion It is concluded that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-42 of 42 references · Page 1 of 1

CITED BY

Showing 1-8 of 8 citing papers · Page 1 of 1