UvA-DARE ( Digital Academic Repository ) Systems biology tools for toxicology

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism.

  2012cited by this paper
• What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics–pharmacodynamics platform

  2011cited by this paper
• Managing the challenge of chemically reactive metabolites in drug development

  2011cited by this paper
• The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs

  2010cited by this paper
• Why does yeast ferment? A flux balance analysis study.

  2010cited by this paper
• Systems biochemistry in practice: experimenting with modelling and understanding, with regulation and control.

  2010cited by this paper
• Flux balance analysis of biological systems: applications and challenges

  2009cited by this paper
• Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters

  2009cited by this paper
• Simplified yet highly accurate enzyme kinetics for cases of low substrate concentrations

  2009cited by this paper
• Time‐dependent regulation analysis dissects shifts between metabolic and gene‐expression regulation during nitrogen starvation in baker’s yeast

  2009cited by this paper
• Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

  2009influential reference
• Systems biology towards life in silico: mathematics of the control of living cells

  2009cited by this paper
• Identification of metabolic fluxes in hepatic cells from transient 13C‐labeling experiments: Part I. Experimental observations

  2008cited by this paper
• Sloppiness, robustness, and evolvability in systems biology.

  2008cited by this paper
• Identification of metabolic fluxes in hepatic cells from transient 13C‐labeling experiments: Part II. Flux estimation

  2008cited by this paper
• Integrating systems approaches into pharmaceutical sciences.

  2008cited by this paper
• Mathematical modelling of liver regeneration after intoxication with CCl(4).

  2007cited by this paper
• Computational systems biology in drug discovery and development: methods and applications.

  2007influential reference
• The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels

  2007cited by this paper
• Metabolic control analysis to identify optimal drug targets.

  2007influential reference
• The stability and robustness of metabolic states: identifying stabilizing sites in metabolic networks

  2007cited by this paper
• Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis

  2006cited by this paper
• Tools for kinetic modeling of biochemical networks

  2006cited by this paper
• Theoretical Biology and Medical Modelling Open Access Bringing Metabolic Networks to Life: Convenience Rate Law and Thermodynamic Constraints

  2006cited by this paper
• Differential Metabolomics Reveals Ophthalmic Acid as an Oxidative Stress Biomarker Indicating Hepatic Glutathione Consumption*

  2006cited by this paper
• Unraveling the complexity of flux regulation: A new method demonstrated for nutrient starvation in Saccharomyces cerevisiae

  2006cited by this paper
• Systems Biology: Definitions and Perspectives

  2005influential reference
• Systems Biology: Its Practice and Challenges

  2005cited by this paper
• A quadratic programming approach for decomposing steady-state metabolic flux distributions onto elementary modes

  2005cited by this paper
• A method for the determination of flux in elementary modes, and its application to Lactobacillus rhamnosus.

  2004cited by this paper
• Global organization of metabolic fluxes in the bacterium Escherichia coli

  2004cited by this paper
• Network biology: understanding the cell's functional organization

  2004cited by this paper
• Web-based kinetic modelling using JWS Online

  2004cited by this paper
• Metabolic pathways in the post-genome era.

  2003cited by this paper
• Advances in flux balance analysis.

  2003cited by this paper
• Metabolic network structure determines key aspects of functionality and regulation

  2002cited by this paper
• Systems Biology: A Brief Overview

  2002cited by this paper
• A turbo engine with automatic transmission? How to marry chemicomotion to the subtleties and robustness of life.

  2002cited by this paper
• Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei.

  2001cited by this paper
• Intrahepatic amino acid and glucose metabolism in a D‐galactosamine–induced rat liver failure model

  2001cited by this paper
• Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway

  2001cited by this paper
• Error and attack tolerance of complex networks

  2000cited by this paper
• Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective.

  2000cited by this paper
• Compartmentation protects trypanosomes from the dangerous design of glycolysis.

  2000cited by this paper
• Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

  2000cited by this paper
• Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering.

  1999cited by this paper
• Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei.

  1999cited by this paper
• Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: computer simulation and metabolic control analysis.

  1999cited by this paper
• Transient 5-oxoprolinuria (pyroglutamic aciduria) with systemic acidosis in an adult receiving antibiotic therapy.

  1998cited by this paper
• Robustness in simple biochemical networks

  1997cited by this paper
• Mutations in the glutathione synthetase gene cause 5–oxoprolinuria

  1996cited by this paper
• Metabolic regulation: A control analytic perspective

  1995cited by this paper
• The control of flux.

  1995influential reference
• Defining control coefficients in non-ideal metabolic pathways.

  1995cited by this paper
• How do inhibitors and modifiers of individual enzymes affect steady-state fluxes and concentrations in metabolic systems?

  1986cited by this paper
• How do enzyme activities control metabolite concentrations? An additional theorem in the theory of metabolic control.

  1984cited by this paper
• The role of glutathione in detoxication

  1983cited by this paper
• Quantification of the contribution of various steps to the control of mitochondrial respiration.

  1982cited by this paper
• A linear steady-state treatment of enzymatic chains. Critique of the crossover theorem and a general procedure to identify interaction sites with an effector.

  1974cited by this paper
• The Molecular Statistics of an Enzyme Action

  1931cited by this paper
• Reciprocal Relations in Irreversible Processes. II.

  1931cited by this paper
• Theoretical Biology and Medical Modelling Open Access a Mathematical Model of Glutathione Metabolism

  year unknowncited by this paper

• Proteomics in systems toxicology.

  2021cites this paper
• Realizing Cancer Precision Medicine by Integrating Systems Biology and Nanomaterial Engineering

  2020cites this paper
• Systems Biology in Immunotoxicology

  2018cites this paper
• Systems Biology in the Broad Sense

  2017cites this paper
• Investigation of ifosfamide and chloroacetaldehyde renal toxicity through integration of in vitro liver–kidney microfluidic data and pharmacokinetic‐system biology models

  2016cites this paper
• The Application of Omics Technologies to the Study of Mammalian Toxicology

  2015cites this paper
• An introduction to systems toxicology

  2015cites this paper
• Quantitative in vitro to in vivo extrapolation of tissues toxicity.

  2015cites this paper
• Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

  2015cites this paper
• Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity

  2015cites this paper
• The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments

  2015cites this paper
• Guest editorial: SYSTEMS TOXICOLOGY

  2015cites this paper
• Extrapolating In Vitro Results to Predict Human Toxicity

  2014cites this paper
• Systems Biology Application in Toxicology

  2014cites this paper
• Current Concepts in Drug‐Induced Bile Salt Export Pump (BSEP) Interference

  2014cites this paper
• Acute dermal toxicity testing

  2013cites this paper
• Cell culture methods for acute toxicology testing

  2013cites this paper