Antidepressant-like effect of lamotrigine is reversed by veratrine: a possible role of sodium channels in bipolar depression.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Behavioural Brain Research

• Publication date

  2008-08-05

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.bbr.2008.03.007PMID 18433891
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005influential reference
• Forced swimming test in mice: a review of antidepressant activity

  2004cited by this paper
• Potential Mechanisms of Action of Lamotrigine in the Treatment of Bipolar Disorders

  2003cited by this paper
• Novel Anticonvulsants: A New Generation of Mood Stabilizers?

  2000cited by this paper
• Selective depression of low-release probability excitatory synapses by sodium channel blockers.

  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1995cited by this paper
• Auxiliary subunits of voltage-gated ion channels.

  1994cited by this paper
• Auxiliary subunits of voltage-gated ion channels.

  1994cited by this paper
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