The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Cell stress & chaperones (Print)

• Publication date

  2012-02-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12192-012-0327-5PMID 22322357PMCID PMC3368033
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Membrane-Lipid Therapy in Operation: The HSP Co-Inducer BGP-15 Activates Stress Signal Transduction Pathways by Remodeling Plasma Membrane Rafts

  2011cited by this paper
• Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line.

  2010cited by this paper
• BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury.

  2010cited by this paper
• Beneficial effect of the insulin sensitizer (HSP inducer) BGP-15 on olanzapine-induced metabolic disorders.

  2010cited by this paper
• Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats.

  2009cited by this paper
• Improvement of Insulin Sensitivity by a Novel Drug, BGP-15, in Insulin-resistant Patients: A Proof of Concept Randomized Double-blind Clinical Trial

  2009cited by this paper
• Endoplasmic reticulum: nutrient sensor in physiology and pathology.

  2009cited by this paper
• Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

  2009cited by this paper
• Inflammation, heat shock proteins, and type 2 diabetes

  2009cited by this paper
• A Preliminary Investigation of &agr;-Lipoic Acid Treatment of Antipsychotic Drug-Induced Weight Gain in Patients With Schizophrenia

  2008cited by this paper
• HSP72 protects against obesity-induced insulin resistance

  2008cited by this paper
• Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line

  2007cited by this paper
• Can the stress protein response be controlled by 'membrane-lipid therapy'?

  2007cited by this paper
• AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model

  2006cited by this paper
• Metformin for Prevention of Weight Gain and Insulin Resistance with Olanzapine: A Double-Blind Placebo-Controlled Trial

  2006cited by this paper
• Diabetes risk associated with use of olanzapine, quetiapine, and risperidone in veterans health administration patients with schizophrenia.

  2006cited by this paper
• A parametric analysis of olanzapine-induced weight gain in female rats

  2005cited by this paper
• The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response

  2005cited by this paper
• Loss of Defense Against Stress: Diabetes and Heat Shock Proteins

  2005cited by this paper
• Simple flow cytometric method used to assess lipid accumulation in fat cells Published, JLR Papers in Press, March 1, 2004. DOI 10.1194/jlr.D300028-JLR200

  2004cited by this paper
• Consensus development conference on antipsychotic drugs and obesity and diabetes: response to consensus statement.

  2004cited by this paper
• Consensus development conference on antipsychotic drugs and obesity and diabetes.

  2004cited by this paper
• Heat shock protein coinducers with no effect on protein denaturation specifically modulate the membrane lipid phase

  2003cited by this paper
• Induction of hyperglycemia in mice with atypical antipsychotic drugs that inhibit glucose uptake.

  2003cited by this paper
• Antipsychotic-induced weight gain: a comprehensive research synthesis.

  1999cited by this paper
• Does the membrane's physical state control the expression of heat shock and other genes?

  1998cited by this paper
• Bimoclomol: A nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects

  1997cited by this paper

• Mechanopharmacology of cellular microenvironment stiffness: Therapeutic strategies for age‐related diseases

  2025cites this paper
• Cell models to probe the biological bases of Antipsychotic-induced Metabolic Syndrome: towards an individual specific approach.

  2025cites this paper
• The role of granulosa cells in oocyte development and aging: Mechanisms and therapeutic opportunities.

  2025cites this paper
• Resolution of inflammation in chronic disease via restoration of the heat shock response (HSR)

  2024cites this paper
• Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary

  2022cites this paper
• Metronomic 5-Fluorouracil Delivery Primes Skeletal Muscle for Myopathy but Does Not Cause Cachexia

  2021influential citation
• Pharmacological Overview of the BGP-15 Chemical Agent as a New Drug Candidate for the Treatment of Symptoms of Metabolic Syndrome

  2020cites this paper
• Retinoprotection by BGP-15, a Hydroximic Acid Derivative, in a Type II Diabetic Rat Model Compared to Glibenclamide, Metformin, and Pioglitazone

  2020cites this paper
• The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy

  2020cites this paper
• Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.

  2020cites this paper
• The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction

  2020cites this paper
• Heat Shock Proteins, a Key Modulator of Neuroinflammation in Alzheimer’s Disease

  2020cites this paper
• Negative Inotropic Effect of BGP-15 on the Human Right Atrial Myocardium

  2020cites this paper
• Are Heat Shock Proteins an Important Link between Type 2 Diabetes and Alzheimer Disease?

  2020cites this paper
• Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

  2018cites this paper
• Skeletal muscle‐specific overexpression of heat shock protein 72 improves skeletal muscle insulin‐stimulated glucose uptake but does not alter whole body metabolism

  2018cites this paper
• Stress management : multilayer regulation of the heat shock response

  2017cites this paper
• Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility

  2017cites this paper
• Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response

  2017cites this paper
• BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species

  2017cites this paper
• 1 INFLUENCING AND INVESTIGATING INSULIN RESISTANCE BY A MOLECULE WITH A NEW MODE OF ACTION

  2017cites this paper
• Molecular Aspects of Exercise-induced Cardiac Remodeling.

  2016cites this paper
• How to Stabilize Both the Proteins and the Membranes: Diverse Effects of sHsps in Neuroprotection

  2015cites this paper
• Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

  2015cites this paper
• AZ INZULINREZISZTENCIA VIZSGÁLATA ÉS BEFOLYÁSOLÁSA ÚJ HATÁSMECHANIZMUSÚ MOLEKULÁVAL

  2015cites this paper
• Paliperidone Prevents Brain Toll-Like Receptor 4 Pathway Activation and Neuroinflammation in Rat Models of Acute and Chronic Restraint Stress

  2015cites this paper
• Muscle heat shock protein 70 predicts insulin resistance with aging.

  2015cites this paper
• The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

  2014cites this paper
• Chaperoning to the metabolic party

  2014cites this paper
• The role of small GTPase Rac1 in stress signaling

  2014cites this paper
• The role of small GTPase Rac 1 in stress signaling Ph

  2014cites this paper
• Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes

  2014cites this paper
• Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness.

  2013cites this paper
• Synergetic Insulin Sensitizing Effect of Rimonabant and BGP-15 in Zucker-Obes Rats

  2013cites this paper
• EXAMINATION OF THE POTENTIAL ROLE OF AN ANTIDIABETIC DRUG CANDIDATE-BGP-15-IN THE TREATMENT OF SECOND GENERATION ANTIPSYCHOTICS INDUCED SIDE EFFECTS

  2013cites this paper
• Key role of lipids in heat stress management

  2013cites this paper
• A Novel Insulin Sensitizer Drug Candidate—BGP-15—Can Prevent Metabolic Side Effects of Atypical Antipsychotics

  2012cites this paper
• Nutritional lipid supply can control the heat shock response of B16 melanoma cells in culture

  2012cites this paper