{"corpus_id":10097456,"paper_sha":"1c17e7bcfd52be89ebd3cd8044b45679a283012f","doi":"10.1371/journal.pone.0184755","arxiv_id":null,"pmid":28902877,"pmcid":"5597239","mag_id":2754371821,"dblp_id":null,"acl_id":null,"title":"Purification and characterization of a highly specific polyclonal antibody against human extracellular signal-regulated kinase 8 and its detection in lung cancer","year":2017,"publication_date":"2017-09-13","venue":"PLoS ONE","journal":{"name":"PLoS ONE","pages":null,"volume":"12"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":17,"citation_count":10,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Antibodies","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"isolation & purification","mj":false,"ui":"Q000302"}],"ui":"D000906"},{"d":"Antibody Specificity","mj":false,"ui":"D000918"},{"d":"Cell Line, Tumor","mj":false,"ui":"D045744"},{"d":"Cell Nucleus","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D002467"},{"d":"Cytoplasm","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D003593"},{"d":"Databases, Factual","mj":false,"ui":"D016208"},{"d":"Epitopes, B-Lymphocyte","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"}],"ui":"D018985"},{"d":"Extracellular Signal-Regulated MAP Kinases","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"},{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D048049"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Immunohistochemistry","mj":false,"ui":"D007150"},{"d":"Lung Neoplasms","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008175"},{"d":"Software","mj":false,"ui":"D012984"}],"chemicals":[{"n":"Antibodies","ui":"D000906","reg":"0"},{"n":"Epitopes, B-Lymphocyte","ui":"D018985","reg":"0"},{"n":"Extracellular Signal-Regulated MAP Kinases","ui":"D048049","reg":"EC 2.7.11.24"},{"n":"MAPK15 protein, human","ui":"C456320","reg":"EC 2.7.11.24"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0184755&type=printable","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/1c17e7bcfd52be89ebd3cd8044b45679a283012f","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Extracellular signal-regulated kinase 8 (ERK8), proposed as a novel potential therapeutic target for cancer, has been implicated in cell transformation, apoptosis, the protection of genomic integrity, and autophagy. 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