{"corpus_id":1096218,"paper_sha":"834e3a97b34a578684008bfe6ab01d505aead4f3","doi":"10.1155/2014/391947","arxiv_id":null,"pmid":24639909,"pmcid":"3929990","mag_id":2037371534,"dblp_id":null,"acl_id":null,"title":"Ovarian Basaloid Carcinoma with Shadow Cell Differentiation","year":2014,"publication_date":"2014-02-03","venue":"Case Reports in Pathology","journal":{"name":"Case Reports in Pathology","pages":null,"volume":"2014"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","Review"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":26,"citation_count":13,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://downloads.hindawi.com/journals/cripa/2014/391947.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/834e3a97b34a578684008bfe6ab01d505aead4f3","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"So-called shadow cell differentiation (SCD) is typical for pilomatrixoma and other skin lesions with follicular differentiation, but it was rarely described also in some visceral carcinomas. We report a case of ovarian basaloid carcinoma with SCD. The tumor presented as a 14 cm ovarian mass in a 45-year-old woman, and therefore the adnexectomy and hysterectomy were performed. The tumor was of high stage. Multiple metastases were found in the liver, retroperitoneal and mediastinal lymph nodes, and the lung. Histologically, the tumor showed a pattern of high-grade basaloid carcinoma with numerous shadow cells. Extensive histologic examination did not reveal any glandular or preexisting teratoma component. Immunohistochemically, the tumor expressed markers of squamous cell differentiation, such as p63, cytokeratin 5/6, and high-molecular-weight keratin. Cytokeratin 7 and CA125 were positive in scattered cells of the lesion. Estrogen and progesterone receptor, vimentin, and p53 were negative. Beta-catenin showed nuclear and cytoplasmic positivity, indicating possible tumor proliferation/differentiation via Wnt signaling pathway. To our knowledge, SCD in basaloid carcinoma of the ovary was not described before. In addition to the description of the case, we review the literature on SCD in visceral carcinomas.","claims":[{"public_id":"cl_7bef412422f94a646d1add6b90f3ba74","status":"active","text":"Extensive histologic examination found no glandular component or preexisting teratoma component in the tumor.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_7bef412422f94a646d1add6b90f3ba74"},{"public_id":"cl_fb7654dfb32bbc98a79bdcff33c12a90","status":"active","text":"Nuclear and cytoplasmic beta-catenin positivity suggests possible involvement of the Wnt signaling pathway in tumor proliferation and differentiation.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_fb7654dfb32bbc98a79bdcff33c12a90"},{"public_id":"cl_944b250b13ae136c2dfa63dc503d0aa2","status":"active","text":"Ovarian basaloid carcinoma can show shadow cell differentiation with numerous shadow cells.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_944b250b13ae136c2dfa63dc503d0aa2"},{"public_id":"cl_232c99cc38844943ec9f61893475111d","status":"active","text":"Shadow cell differentiation in basaloid carcinoma of the ovary had not been described previously.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_232c99cc38844943ec9f61893475111d"},{"public_id":"cl_13be8ebc5e2480e06f141fa8b44ce076","status":"active","text":"The reported tumor was a high-stage 14 cm ovarian mass with metastases to the liver, retroperitoneal and mediastinal lymph nodes, and the lung.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_13be8ebc5e2480e06f141fa8b44ce076"},{"public_id":"cl_2f943fae74656bca32ed39f5c421e356","status":"active","text":"The tumor expressed squamous cell differentiation markers p63, cytokeratin 5/6, and high-molecular-weight keratin, while estrogen receptor, progesterone receptor, vimentin, and p53 were negative.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_2f943fae74656bca32ed39f5c421e356"}],"concepts":[{"public_id":"co_09c77e8a30683fef507f6229b89c4996","status":"active","name":"shadow cell differentiation","description":"A histologic differentiation pattern characterized by the presence of anucleate shadow cells.","types":["histologic pattern"],"aliases":["SCD"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_09c77e8a30683fef507f6229b89c4996"},{"public_id":"co_21691f43f4a2bd2e44fed0709eff0edc","status":"active","name":"cytokeratin 5/6","description":"A cytokeratin immunohistochemical marker associated with squamous epithelial differentiation.","types":["biomarker"],"aliases":["CK5/6"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_21691f43f4a2bd2e44fed0709eff0edc"},{"public_id":"co_2c6ee13643119732d3c4e8cffc48080b","status":"active","name":"tumor proliferation and differentiation","description":"Cellular processes governing tumor growth and maturation state.","types":["biological process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2c6ee13643119732d3c4e8cffc48080b"},{"public_id":"co_30364a0ef640869283a3145d43e3ac58","status":"active","name":"preexisting teratoma component","description":"A teratomatous tissue component present before or within the tumor.","types":["histologic component"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_30364a0ef640869283a3145d43e3ac58"},{"public_id":"co_35787e4b23d1954061bb4a8f7ad0837e","status":"active","name":"metastases","description":"Secondary tumor deposits found in distant organs or lymph nodes.","types":["finding"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_35787e4b23d1954061bb4a8f7ad0837e"},{"public_id":"co_36d150b8b6dfc56755260ad16fb7c39f","status":"active","name":"p63","description":"A nuclear transcription factor used as an immunohistochemical marker of squamous differentiation.","types":["biomarker"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_36d150b8b6dfc56755260ad16fb7c39f"},{"public_id":"co_43b8f5068ad22d3ad962c966b5356e41","status":"active","name":"ovarian basaloid carcinoma","description":"A basaloid malignant epithelial tumor arising in the ovary.","types":["cancer"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_43b8f5068ad22d3ad962c966b5356e41"},{"public_id":"co_56bf72844b2b441f8efbb5350290a680","status":"active","name":"histologic examination","description":"Microscopic examination of tumor tissue used to assess structural features.","types":["diagnostic method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_56bf72844b2b441f8efbb5350290a680"},{"public_id":"co_764b910aafa2a1770ecca1112300f0b3","status":"active","name":"beta-catenin","description":"A cell adhesion and signaling protein assessed by immunohistochemistry in the tumor.","types":["biomarker"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_764b910aafa2a1770ecca1112300f0b3"},{"public_id":"co_7b036e814d8baac6746bdb606e6da605","status":"active","name":"Wnt signaling pathway","description":"A cell signaling pathway implicated in regulation of proliferation and differentiation.","types":["signaling pathway"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_7b036e814d8baac6746bdb606e6da605"},{"public_id":"co_80c0c0b331ca1bae989db56ede443738","status":"active","name":"ovarian mass","description":"A tumor mass located in the ovary; here it measured 14 cm.","types":["finding"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_80c0c0b331ca1bae989db56ede443738"},{"public_id":"co_cde2842a251368f460c9649d30936626","status":"active","name":"shadow cells","description":"Anucleate eosinophilic cells seen in lesions with shadow cell differentiation.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_cde2842a251368f460c9649d30936626"},{"public_id":"co_dccfdeaae642b4779623522f6fbdd02b","status":"active","name":"glandular component","description":"A gland-forming histologic element within a tumor.","types":["histologic component"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_dccfdeaae642b4779623522f6fbdd02b"},{"public_id":"co_e47d9ea065d7091cbf023167f86a814b","status":"active","name":"high stage","description":"An advanced disease stage indicating extensive tumor spread.","types":["clinical stage"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e47d9ea065d7091cbf023167f86a814b"},{"public_id":"co_e88c4f0884f4107426dd093454041fe1","status":"active","name":"squamous cell differentiation","description":"A tumor differentiation pattern showing features of squamous epithelial cells.","types":["histologic pattern"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e88c4f0884f4107426dd093454041fe1"}],"external_ids":{"DOI":"10.1155/2014/391947","ArXiv":null,"PubMed":24639909,"PubMedCentral":"3929990","MAG":2037371534,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"http://downloads.hindawi.com/journals/cripa/2014/391947.pdf","landing_url":"https://www.semanticscholar.org/paper/834e3a97b34a578684008bfe6ab01d505aead4f3","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":636007,"paper_uid":"341f9447-0350-4beb-b6d6-72cbfb727e6e","canonical_identity":{"paper_id":636007,"paper_uid":"341f9447-0350-4beb-b6d6-72cbfb727e6e","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/1096218"}