{"corpus_id":11789948,"paper_sha":"9eac9e97b3de7a41f7347c2a278540ec10c4174a","doi":"10.4314/AJTCAM.V4I4.31246","arxiv_id":null,"pmid":20161921,"pmcid":"PMC2816518","mag_id":1865061449,"dblp_id":null,"acl_id":null,"title":"Anti-diarrheal activity of the leaf extracts of Daniellia oliveri Hutch and Dalz (Fabaceae) and Ficus sycomorus Miq (Moraceae).","year":2008,"publication_date":"2008-10-15","venue":"African Journal of Traditional Complementary and Alternative Medicines","journal":{"name":"African journal of traditional, complementary, and alternative medicines : AJTCAM","pages":"\n          524-8\n        ","volume":"4 4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Environmental Science"],"reference_count":19,"citation_count":69,"influential_citation_count":2,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.ajol.info/index.php/ajtcam/article/download/31246/36832","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/9eac9e97b3de7a41f7347c2a278540ec10c4174a","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The leaves of the plants Daniellia oliveri (Fabaceae) and Ficus sycomorus (Moraceae) used in diarrhea treatment in Hausa ethnomedicine of Northern Nigeria were investigated. The study was carried out on perfused isolated rabbit jejunum and castor oil-induced diarrhea in mice. The n-butanol extracts: NBD and NBF (0.16-3.2 mg/ml) caused a dose-dependent relaxation of isolated rabbit jejunum. The acute toxicity test for NBD and NBT in mice established an i.p LD(50) of > 4000 mg/kg for D. oliveri and 1131.4 mg/kg for F. sycomorus. In castor oil-induced diarrhea, 80% protection was observed for D. oliveri at doses of 200 mg/kg and 60% protection was observed at 100 mg/kg and 50 mg/kg respectively. For F. sycomorus 100% protection was observed at doses of 120 mg/kg and 60 mg/kg, for the n-butanol extract. The antidiarrheal activity was comparable to loperamide 5 mg/kg. The result revealed that the extracts have pharmacological activity against diarrhea.","claims":[{"public_id":"cl_603c22acff2f88f418158efda6b16d6e","status":"active","text":"In castor oil-induced diarrhea in mice, the n-butanol extract of Daniellia oliveri produces 80% protection at 200 mg/kg and 60% protection at 100 mg/kg and 50 mg/kg.","confidence":0.9,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_603c22acff2f88f418158efda6b16d6e"},{"public_id":"cl_369a7a0bd892ce0266f7ea7864458cbf","status":"active","text":"In castor oil-induced diarrhea in mice, the n-butanol extract of Ficus sycomorus produces 100% protection at 120 mg/kg and 60 mg/kg.","confidence":0.9,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_369a7a0bd892ce0266f7ea7864458cbf"},{"public_id":"cl_bd0833b7890be862ec565bf618877051","status":"active","text":"The antidiarrheal activity of the n-butanol extracts is comparable to loperamide at 5 mg/kg.","confidence":0.8,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_bd0833b7890be862ec565bf618877051"},{"public_id":"cl_05295ca80516f6539b9acb85e2895dcd","status":"active","text":"The intraperitoneal LD50 in mice is greater than 4000 mg/kg for Daniellia oliveri and 1131.4 mg/kg for Ficus sycomorus.","confidence":0.9,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ 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