{"corpus_id":122839481,"paper_sha":"b26eb5cca8f7a72276be76dbc0e5d2f09ad0e94f","doi":"10.1093/BIOMET/64.2.191","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":2127151679,"dblp_id":null,"acl_id":null,"title":"Group sequential methods in the design and analysis of clinical trials","year":1977,"publication_date":"1977-08-01","venue":"","journal":{"name":"Biometrika","pages":"191-199","volume":"64"},"journal_issn":null,"journal_title":null,"publication_types":[],"pubmed_pub_types":null,"s2_fields_of_study":["Medicine","Mathematics"],"reference_count":4,"citation_count":1781,"influential_citation_count":161,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"In clinical trials with sequential patient entry, fixed sample size designs are unjustified on ethical grounds and sequential designs are often impracticable. 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