{"corpus_id":12656214,"paper_sha":"e71d42d69d02e857221e244b98ffcd918377ef31","doi":"10.1097/DAD.0000000000001092","arxiv_id":null,"pmid":29329129,"pmcid":null,"mag_id":2782562805,"dblp_id":null,"acl_id":null,"title":"Primary Cutaneous Spindle Cell Squamous Carcinoma Expressing Smooth Muscle Actin: Diagnostic Pitfalls.","year":2018,"publication_date":"2018-06-01","venue":"American journal of dermatopathology","journal":{"name":"The American Journal of Dermatopathology","pages":null,"volume":null},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","CaseReport"],"pubmed_pub_types":["Case Reports","Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":16,"citation_count":8,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Actins","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"},{"q":"biosynthesis","mj":true,"ui":"Q000096"}],"ui":"D000199"},{"d":"Biomarkers, Tumor","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D014408"},{"d":"Carcinoma, Squamous Cell","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D002294"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Muscle, Smooth","mj":false,"qs":[{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D009130"},{"d":"Skin Neoplasms","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D012878"}],"chemicals":[{"n":"Actins","ui":"D000199","reg":"0"},{"n":"Biomarkers, Tumor","ui":"D014408","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Alpha smooth muscle actin (SMA) belongs to the actin proteins. It is a known immunohistochemical marker for tumors of mesenchymal origin. There have been reports of expression of SMA in certain epithelial malignancies in the head and neck and genital regions. In this study, the authors report a primary cutaneous spindle cell squamous carcinoma expressing SMA. Both high- and low-molecular-weight keratins and p63 were positive, and S100 protein, SOX10, MART-1/Melan-A, and muscle-specific actin stains were negative. This case highlights that an epithelial tumor could express a mesenchymal marker, thereby making the diagnosis problematic.","claims":[{"public_id":"cl_b44cad1906b24c02c6118ab748c58da6","status":"active","text":"A primary cutaneous spindle cell squamous carcinoma expressed smooth muscle actin.","confidence":0.96,"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_b44cad1906b24c02c6118ab748c58da6"},{"public_id":"cl_7bc7e6e0441b2585f53d67270998ae89","status":"active","text":"Expression of a mesenchymal marker by an epithelial tumor can make diagnosis 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