{"corpus_id":13505196,"paper_sha":"1d288a1af729b4fdbf7979169d69930429865e6b","doi":"10.3390/molecules21030331","arxiv_id":null,"pmid":26978330,"pmcid":"6274257","mag_id":2294515230,"dblp_id":null,"acl_id":null,"title":"Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology","year":2016,"publication_date":"2016-03-01","venue":"Molecules","journal":{"name":"Molecules","pages":null,"volume":"21"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Review"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":207,"citation_count":200,"influential_citation_count":8,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Eurycoma","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"classification","mj":false,"ui":"Q000145"}],"ui":"D035701"},{"d":"Herbal Medicine","mj":true,"ui":"D029001"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Medicine, Traditional","mj":true,"ui":"D008519"},{"d":"Metabolomics","mj":false,"qs":[{"q":"methods","mj":false,"ui":"Q000379"}],"ui":"D055432"},{"d":"Plant Extracts","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010936"}],"chemicals":[{"n":"Plant Extracts","ui":"D010936","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.mdpi.com/1420-3049/21/3/331/pdf?version=1457604721","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/1d288a1af729b4fdbf7979169d69930429865e6b","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50) of the alcoholic extract of E. longifolia in mice is between 1500–2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents’ identification, determination, further development and most importantly, the standardization. Besides the available data, more evidence is required regarding its therapeutic efficacy and safety, so it can be considered a rich herbal source of new drug candidates. It is very important to conserve this valuable medicinal plant for the health benefit of future generations.","claims":[{"public_id":"cl_e8dbfd9d4f832d1bca0f8997a9a4223c","status":"active","text":"Liver function tests and renal function tests showed no adverse changes at normal daily dose and chronic use of Eurycoma longifolia Jack.","confidence":0.9,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e8dbfd9d4f832d1bca0f8997a9a4223c"},{"public_id":"cl_13e3d5a52898308321a62754c1e8d8dd","status":"active","text":"Quassinoids account for a major portion of the root phytochemicals of Eurycoma longifolia Jack.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_13e3d5a52898308321a62754c1e8d8dd"},{"public_id":"cl_961896951ea20b8d9678af70df502c8b","status":"active","text":"The oral LD50 of the alcoholic extract of Eurycoma longifolia Jack in mice is between 1500–2000 mg/kg.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_961896951ea20b8d9678af70df502c8b"},{"public_id":"cl_bc59714ee317429f62d82933262ef4ef","status":"active","text":"The oral LD50 of the aqueous extract of Eurycoma longifolia Jack in mice is more than 3000 mg/kg.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_bc59714ee317429f62d82933262ef4ef"}],"concepts":[{"public_id":"co_0dacd0cd85550b50d904b9acd2015a50","status":"active","name":"root phytochemicals","description":"The chemical constituents present in the roots of Eurycoma longifolia Jack.","types":["substance"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0dacd0cd85550b50d904b9acd2015a50"},{"public_id":"co_1da1e301732674abefa71bb6663593ea","status":"active","name":"chronic use","description":"Long-term administration of Eurycoma longifolia Jack evaluated for safety.","types":["dosing regimen"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1da1e301732674abefa71bb6663593ea"},{"public_id":"co_3f7b6849b3b9fcbc72f1823c71e1cdf5","status":"active","name":"oral LD50","description":"The median lethal dose determined by oral administration in mice.","types":["measurement"],"aliases":["lethal dose 50"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3f7b6849b3b9fcbc72f1823c71e1cdf5"},{"public_id":"co_469baadada698bbd93ae7dde3358dd55","status":"active","name":"renal function tests","description":"Tests assessing kidney health, showing no adverse changes in the study.","types":["assay"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_469baadada698bbd93ae7dde3358dd55"},{"public_id":"co_5e04e3a241036b02757791a9130b7ee3","status":"active","name":"Eurycoma longifolia Jack","description":"A traditional herbal medicine, known as tongkat ali, used for aphrodisiac effects and various ailments.","types":["plant"],"aliases":["tongkat ali"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5e04e3a241036b02757791a9130b7ee3"},{"public_id":"co_845f2d4e75ca621eab308aeab6001f44","status":"active","name":"quassinoids","description":"A class of bioactive compounds that are a major component of Eurycoma longifolia Jack root phytochemicals.","types":["phytochemical"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_845f2d4e75ca621eab308aeab6001f44"},{"public_id":"co_ba217012f44470f637ba94cf108da42a","status":"active","name":"liver function tests","description":"Tests assessing liver health, showing no adverse changes in the study.","types":["assay"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_ba217012f44470f637ba94cf108da42a"},{"public_id":"co_cc3165f54275cf3575b7a5a50dcfee3a","status":"active","name":"mice","description":"The animal model used for acute toxicity evaluation.","types":["model organism"],"aliases":["mouse"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_cc3165f54275cf3575b7a5a50dcfee3a"},{"public_id":"co_e52fdab869cd6c21669119144b5bf016","status":"active","name":"normal daily dose","description":"The recommended daily intake of Eurycoma longifolia Jack evaluated for safety.","types":["dosing regimen"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e52fdab869cd6c21669119144b5bf016"},{"public_id":"co_f7ba9b8f42a8445908a3445d7b41c1de","status":"active","name":"aqueous extract","description":"An extract prepared using water as solvent, used in acute toxicity study.","types":["extract"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f7ba9b8f42a8445908a3445d7b41c1de"},{"public_id":"co_f9c99bd539c4e0727083b18ca8a0d10f","status":"active","name":"alcoholic extract","description":"An extract prepared using alcohol as solvent, used in acute toxicity study.","types":["extract"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f9c99bd539c4e0727083b18ca8a0d10f"}],"external_ids":{"DOI":"10.3390/molecules21030331","ArXiv":null,"PubMed":26978330,"PubMedCentral":"6274257","MAG":2294515230,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://www.mdpi.com/1420-3049/21/3/331/pdf?version=1457604721","landing_url":"https://www.semanticscholar.org/paper/1d288a1af729b4fdbf7979169d69930429865e6b","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":631639,"paper_uid":"91d74f59-dc97-477b-a046-ad5635d4cb16","canonical_identity":{"paper_id":631639,"paper_uid":"91d74f59-dc97-477b-a046-ad5635d4cb16","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/13505196"}