{"corpus_id":14596528,"paper_sha":"311981ede11ac9f95a4b1e76166e737ebd4eba94","doi":"10.4317/medoral.20391","arxiv_id":null,"pmid":26449426,"pmcid":"4670242","mag_id":2256883972,"dblp_id":null,"acl_id":null,"title":"A 3 dimensional assessment of the depth of tumor invasion in microinvasive tongue squamous cell carcinoma - A case series analysis","year":2015,"publication_date":"2015-10-09","venue":"Medicina Oral","journal":{"name":"Medicina Oral, Patología Oral y Cirugía Bucal","pages":"e645 - e650","volume":"20"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Mathematics"],"reference_count":29,"citation_count":7,"influential_citation_count":1,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Carcinoma, Squamous Cell","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D002294"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Imaging, Three-Dimensional","mj":true,"ui":"D021621"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Neoplasm Invasiveness","mj":false,"ui":"D009361"},{"d":"Tongue Neoplasms","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D014062"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Background Accurate assessment of the depth of tumor invasion (DI) in microinvasive squamous cell carcinoma (MISCC) of the tongue is critical to prognosis. An arithmetic model is generated to determine a reliable method of measurement of DI and correlate this with the local recurrence. Material and Methods Tumor thickness (TT) and DI were measured in tissue sections of 14 cases of MISCC of the tongue, by manual ocular micrometer and digital image analysis at four reference points (A, B, C, and D). The comparison of TT and DI with relevant clinicopathologic parameters was assessed using Mann Whitney U test. Reliability of these methods and the values obtained were compared and correlated with the recurrence of tumors by Wilcoxon Signed Ranks Test. 3D reconstruction of the lesion was done on a Cartesian coordinate system. X face was on the YZ plane and Z face was on the XY plane of the coordinate system. Results Computer generated 3D model of oral mucosa in four cases that recurred showed increased DI in the Z coordinate compared to the XY coordinate. The median DI measurements between XY and Z coordinates in these cases showed no significant difference (Wilcoxon Signed Ranks Test, p = 0.068). Conclusions The assessment of DI in 3 dimensions is critical for accurate assessment of MISCC and precise DI allows complete removal of tumor. Key words:Depth of invasion, tumor thickness, microinvasive squamous cell carcinoma, tongue squamous cell carcinoma.","claims":[{"public_id":"cl_830b5e03619b9bf17ac35b1d6caa5399","status":"active","text":"Assessment of depth of tumor invasion in three dimensions is critical for accurate assessment of microinvasive squamous cell carcinoma of the tongue.","confidence":0.86,"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_830b5e03619b9bf17ac35b1d6caa5399"},{"public_id":"cl_5253188aa43f52b9ac895fb01cb376c3","status":"active","text":"Computer-generated 3D models of oral mucosa in four recurrent cases showed increased depth of tumor invasion in the Z coordinate compared with the XY coordinate.","confidence":0.9,"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_5253188aa43f52b9ac895fb01cb376c3"},{"public_id":"cl_8618e896df376e1b9756756377788370","status":"active","text":"Median depth of tumor invasion measurements between the XY and Z coordinates in recurrent cases showed no significant difference by Wilcoxon Signed Ranks Test, with p = 0.068.","confidence":0.9,"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_8618e896df376e1b9756756377788370"},{"public_id":"cl_0761e85838f4ba0d9693229c128ad935","status":"active","text":"Three-dimensional reconstruction of the lesion was performed on a Cartesian coordinate system with the X face on the YZ plane and the Z face on the XY plane.","confidence":0.92,"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_0761e85838f4ba0d9693229c128ad935"},{"public_id":"cl_80bc773421d3c25086cfd3d6df65204c","status":"active","text":"Tumor thickness and depth of tumor invasion were measured in tissue sections from 14 cases of microinvasive squamous cell carcinoma of the tongue using manual ocular micrometer and digital image analysis at four reference points.","confidence":0.95,"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_80bc773421d3c25086cfd3d6df65204c"}],"concepts":[{"public_id":"co_070967fd1863192740e90b35d79dde41","status":"active","name":"digital image analysis","description":"A computer-assisted measurement method used to assess tumor thickness and depth of invasion in tissue sections.","types":["measurement method"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_070967fd1863192740e90b35d79dde41"},{"public_id":"co_2a5486a3053f5c0bc747948df66788d4","status":"active","name":"depth of tumor invasion","description":"A measurement of how deeply the tumor extends into tissue in the examined tongue carcinoma sections.","types":["measurement"],"aliases":["DI","Depth of invasion"],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_2a5486a3053f5c0bc747948df66788d4"},{"public_id":"co_377b7e0a59c923cbf630f42bd1f33dea","status":"active","name":"microinvasive squamous cell carcinoma of the tongue","description":"A tongue squamous cell carcinoma subtype examined in the case series for invasion measurements.","types":["disease"],"aliases":["MISCC"],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_377b7e0a59c923cbf630f42bd1f33dea"},{"public_id":"co_3866159ad27ee5c3322c08f7b07c25bf","status":"active","name":"lesion","description":"The tumor-containing tissue area reconstructed for three-dimensional assessment.","types":["anatomical target"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_3866159ad27ee5c3322c08f7b07c25bf"},{"public_id":"co_7736b6f8f98113356c99cf8018aac4cb","status":"active","name":"manual ocular micrometer","description":"A manual microscope-based measuring method used to assess tumor thickness and depth of invasion.","types":["measurement method"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_7736b6f8f98113356c99cf8018aac4cb"},{"public_id":"co_7f607a7e63b4dfb19f978ab10a86c177","status":"active","name":"local recurrence","description":"Return of the tumor locally after treatment, used as a clinical outcome for correlation with invasion measurements.","types":["clinical outcome"],"aliases":["recurrence of tumors"],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_7f607a7e63b4dfb19f978ab10a86c177"},{"public_id":"co_7fd9d269288ee44e24327c2631e9ee28","status":"active","name":"oral mucosa","description":"The mouth lining modeled in recurrent cases to assess tumor invasion patterns.","types":["tissue"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_7fd9d269288ee44e24327c2631e9ee28"},{"public_id":"co_86bbd321a1a05733550fc1e5310d3c2e","status":"active","name":"Cartesian coordinate system","description":"The coordinate framework used to reconstruct the lesion in three dimensions.","types":["coordinate system"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_86bbd321a1a05733550fc1e5310d3c2e"},{"public_id":"co_a77fb4ecf7ded4b0331c91163d16280c","status":"active","name":"3D reconstruction","description":"A three-dimensional modeling approach used to represent the lesion for invasion assessment.","types":["modeling method"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_a77fb4ecf7ded4b0331c91163d16280c"},{"public_id":"co_c12dbe1458a71defa4ce84ae84f82eac","status":"active","name":"Wilcoxon Signed Ranks Test","description":"A statistical test used to compare depth of invasion measurements between coordinate-based views.","types":["statistical test"],"aliases":[],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_c12dbe1458a71defa4ce84ae84f82eac"},{"public_id":"co_e4c66b011c109997af36c928e8e5a4aa","status":"active","name":"tumor thickness","description":"A tissue-section measurement compared with depth of invasion in the examined tongue carcinoma cases.","types":["measurement"],"aliases":["TT"],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_e4c66b011c109997af36c928e8e5a4aa"},{"public_id":"co_e953ebdf9f7f5da19e66f8d06ea6d193","status":"active","name":"reference points","description":"The four labeled locations A, B, C, and D used for measuring tumor thickness and depth of invasion.","types":["measurement location"],"aliases":["A, B, C, and D"],"contributors":[{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["extraction"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_e953ebdf9f7f5da19e66f8d06ea6d193"}],"external_ids":{"DOI":"10.4317/medoral.20391","ArXiv":null,"PubMed":26449426,"PubMedCentral":"4670242","MAG":2256883972,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/14596528","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":630951,"paper_uid":"1e72a22e-2142-4e60-909b-8eb75258b069","canonical_identity":{"paper_id":630951,"paper_uid":"1e72a22e-2142-4e60-909b-8eb75258b069","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/14596528"}