{"corpus_id":1467369,"paper_sha":"8c7ce25fadd88886e84a5dd77578b7a9c92649fa","doi":"10.1007/s00109-008-0318-2","arxiv_id":null,"pmid":18322669,"pmcid":"2374880","mag_id":2098806985,"dblp_id":null,"acl_id":null,"title":"Prorenin anno 2008","year":2008,"publication_date":"2008-03-06","venue":"Journal of molecular medicine","journal":{"name":"Journal of Molecular Medicine (Berlin, Germany)","pages":"655 - 658","volume":"86"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":30,"citation_count":24,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Angiotensins","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D000809"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Receptors, Cell Surface","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D011956"},{"d":"Renin","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D012083"},{"d":"Prorenin Receptor","mj":false,"ui":"D000093342"},{"d":"Renin Inhibitors","mj":false,"ui":"D000092502"}],"chemicals":[{"n":"Angiotensins","ui":"D000809","reg":"0"},{"n":"Receptors, Cell Surface","ui":"D011956","reg":"0"},{"n":"Renin","ui":"D012083","reg":"EC 3.4.23.15"},{"n":"Prorenin Receptor","ui":"D000093342","reg":"0"},{"n":"Renin Inhibitors","ui":"D000092502","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://link.springer.com/content/pdf/10.1007/s00109-008-0318-2.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/8c7ce25fadd88886e84a5dd77578b7a9c92649fa","s2_open_access_license":"CCBYNC","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.","claims":[{"public_id":"cl_e858baa2ee8c055ae7d8ce4dd2b87a43","status":"active","text":"Binding to the (pro)renin receptor has angiotensin-dependent and angiotensin-independent consequences.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e858baa2ee8c055ae7d8ce4dd2b87a43"},{"public_id":"cl_d937a733672174dd619f84c614151c42","status":"active","text":"Prorenin has elevated levels in diabetic subjects with microvascular complications, suggesting a role beyond being an inactive renin precursor.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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