{"corpus_id":15039371,"paper_sha":"2b2c5779577aa17f62f0d1514ba0f2db7d3d0dfc","doi":"10.1093/ndt/gfn667","arxiv_id":null,"pmid":19103734,"pmcid":null,"mag_id":2108298583,"dblp_id":null,"acl_id":null,"title":"Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis.","year":2008,"publication_date":"2008-10-08","venue":"Nephrology, Dialysis and Transplantation","journal":{"name":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association","pages":"\n          1039-47\n        ","volume":"24 3"},"journal_issn":null,"journal_title":null,"publication_types":["Review","MetaAnalysis","JournalArticle"],"pubmed_pub_types":["Journal Article","Meta-Analysis","Research Support, Non-U.S. Gov't","Systematic Review"],"s2_fields_of_study":["Medicine"],"reference_count":55,"citation_count":744,"influential_citation_count":33,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Delayed Graft Function","mj":false,"qs":[{"q":"etiology","mj":false,"ui":"Q000209"},{"q":"mortality","mj":true,"ui":"Q000401"}],"ui":"D051799"},{"d":"Graft Rejection","mj":false,"ui":"D006084"},{"d":"Graft Survival","mj":false,"ui":"D006085"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Kidney Failure, Chronic","mj":false,"qs":[{"q":"mortality","mj":true,"ui":"Q000401"},{"q":"surgery","mj":true,"ui":"Q000601"}],"ui":"D007676"},{"d":"Kidney Transplantation","mj":false,"qs":[{"q":"adverse effects","mj":true,"ui":"Q000009"}],"ui":"D016030"},{"d":"Survival Rate","mj":false,"ui":"D015996"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://academic.oup.com/ndt/article-pdf/24/3/1039/7635853/gfn667.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/2b2c5779577aa17f62f0d1514ba0f2db7d3d0dfc","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"BACKGROUND: Delayed graft function (DGF) is a common complication of renal transplantation. The short-term consequences of DGF are well known, but the long-term relationship between DGF and patient and graft survival is controversial in the published literature. We conducted a systematic review and meta-analysis to precisely estimate these relationships. METHODS: We performed a literature search for original studies published through March 2007 pertaining to long-term (>6 months) outcomes of DGF. The primary outcome was graft survival. Secondary outcomes were patient survival, acute rejection and kidney function. RESULTS: When compared to patients without DGF, patients with DGF had a 41% increased risk of graft loss (RR 1.41, 95% CI 1.27-1.56) at 3.2 years of follow-up. There was no significant relationship between DGF and patient survival at 5 years (RR 1.14, 95% CI 0.94-1.39). The mean creatinine in the non-DGF group was 1.6 mg/dl. Patients with DGF had a higher mean serum creatinine (0.66 mg/dl, 95% CI 0.57-0.74) compared to patients without DGF at 3.5 years of follow-up. DGF was associated with a 38% relative increase in the risk of acute rejection (RR 1.38, 95% CI 1.29-1.47). CONCLUSION: The results of this meta-analysis emphasize and quantify the long-term detrimental association between DGF and important graft outcomes like graft survival, acute rejection and renal function. Efforts to prevent and treat DGF should be aggressively investigated in order to improve graft survival given the deficit in the number of kidney donors.","claims":[{"public_id":"cl_24ac6da51ddb790187a802c5b016251f","status":"active","text":"Delayed graft function is associated with a 38% relative increase in the risk of acute rejection.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_24ac6da51ddb790187a802c5b016251f"},{"public_id":"cl_364549d1cf39430c59508ecd31b38bc4","status":"active","text":"Delayed graft function is associated with a 41% increased risk of graft loss at 3.2 years of follow-up.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_364549d1cf39430c59508ecd31b38bc4"},{"public_id":"cl_fb1be1b862e92cd33af3e64bcccb0c5f","status":"active","text":"Delayed graft function is associated with worse long-term renal function, reflected by higher mean serum creatinine at 3.5 years of follow-up.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_fb1be1b862e92cd33af3e64bcccb0c5f"},{"public_id":"cl_e875308ca10cc0c1751fa8577fb72a33","status":"active","text":"No significant relationship is observed between delayed graft function and patient survival at 5 years.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e875308ca10cc0c1751fa8577fb72a33"}],"concepts":[{"public_id":"co_22dd9f22fa6b78feaf4c1b0eb750a876","status":"active","name":"delayed graft function","description":"A complication of renal transplantation in which the transplanted kidney does not function immediately after surgery.","types":["condition"],"aliases":["DGF"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_22dd9f22fa6b78feaf4c1b0eb750a876"},{"public_id":"co_33bc237139a2ec4065406f0d19f10c8b","status":"active","name":"serum creatinine","description":"A blood biomarker used to assess kidney function.","types":["biomarker","measurement"],"aliases":["creatinine"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_33bc237139a2ec4065406f0d19f10c8b"},{"public_id":"co_5ab6f650ce89e6d551a004ddf6e8622d","status":"active","name":"patient survival","description":"The survival of transplant recipients over a specified follow-up period.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5ab6f650ce89e6d551a004ddf6e8622d"},{"public_id":"co_ba97ff3ce1058fea0f36496e24711d10","status":"active","name":"graft survival","description":"The duration for which the transplanted kidney continues to function without graft loss.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_ba97ff3ce1058fea0f36496e24711d10"},{"public_id":"co_c5682c671b14127e2f8743af2ba51657","status":"active","name":"kidney function","description":"Functional performance of the transplanted kidney as assessed by clinical measures.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c5682c671b14127e2f8743af2ba51657"},{"public_id":"co_d5dc65ac7adabc2f7d3e2e5b65b0acce","status":"active","name":"renal transplantation","description":"Surgical transplantation of a kidney into a recipient.","types":["procedure"],"aliases":["kidney transplantation"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d5dc65ac7adabc2f7d3e2e5b65b0acce"},{"public_id":"co_e34c13d94fa5810f3b936b47461bcd22","status":"active","name":"acute rejection","description":"An early immune-mediated rejection episode affecting the transplanted kidney.","types":["outcome","complication"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e34c13d94fa5810f3b936b47461bcd22"},{"public_id":"co_f5d736c85002499b6d020bc9a6c7f7a0","status":"active","name":"systematic review and meta-analysis","description":"A review method that systematically identifies studies and statistically combines their results.","types":["review method"],"aliases":["meta-analysis","systematic review"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f5d736c85002499b6d020bc9a6c7f7a0"},{"public_id":"co_f7ecdf1db4a5f9198fc29f4970257b83","status":"active","name":"graft loss","description":"Failure or loss of function of the transplanted kidney.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f7ecdf1db4a5f9198fc29f4970257b83"}],"external_ids":{"DOI":"10.1093/ndt/gfn667","ArXiv":null,"PubMed":19103734,"PubMedCentral":null,"MAG":2108298583,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://academic.oup.com/ndt/article-pdf/24/3/1039/7635853/gfn667.pdf","landing_url":"https://www.semanticscholar.org/paper/2b2c5779577aa17f62f0d1514ba0f2db7d3d0dfc","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":null,"status":"BRONZE","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":631143,"paper_uid":"7ba49fff-6a1a-42db-91df-e3f1f8f93d33","canonical_identity":{"paper_id":631143,"paper_uid":"7ba49fff-6a1a-42db-91df-e3f1f8f93d33","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/15039371"}