{"corpus_id":165163322,"paper_sha":"3d74783b4af2ea1c6e37f84e895a73819c4a07c4","doi":"10.1016/j.jaip.2019.05.009","arxiv_id":null,"pmid":31128376,"pmcid":"PMC6842686","mag_id":2946495325,"dblp_id":null,"acl_id":null,"title":"Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis.","year":2019,"publication_date":"2019-11-01","venue":"Journal of Allergy and Clinical Immunology: In Practice","journal":{"name":"The journal of allergy and clinical immunology. In practice","pages":null,"volume":null},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, N.I.H., Extramural","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine"],"reference_count":37,"citation_count":350,"influential_citation_count":18,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Asthma","mj":false,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D001249"},{"d":"Chronic Disease","mj":false,"ui":"D002908"},{"d":"Comorbidity","mj":false,"ui":"D015897"},{"d":"Eosinophil Cationic Protein","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D047150"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Glycoproteins","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D006023"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Interferon-gamma","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D007371"},{"d":"Interleukin-17","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D020381"},{"d":"Lysophospholipase","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D008245"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Nasal Polyps","mj":true,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D009298"},{"d":"Olfaction Disorders","mj":false,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D000857"},{"d":"Phenotype","mj":false,"ui":"D010641"},{"d":"Rhinitis","mj":true,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D012220"},{"d":"Sinusitis","mj":true,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D012852"},{"d":"Young Adult","mj":false,"ui":"D055815"}],"chemicals":[{"n":"Glycoproteins","ui":"D006023","reg":"0"},{"n":"IL17A protein, human","ui":"C508717","reg":"0"},{"n":"Interleukin-17","ui":"D020381","reg":"0"},{"n":"Interferon-gamma","ui":"D007371","reg":"82115-62-6"},{"n":"Lysophospholipase","ui":"D008245","reg":"EC 3.1.1.5"},{"n":"lysolecithin acylhydrolase","ui":"C011711","reg":"EC 3.1.1.5"},{"n":"Eosinophil Cationic Protein","ui":"D047150","reg":"EC 3.1.27.-"},{"n":"RNASE3 protein, human","ui":"C479220","reg":"EC 3.1.27.-"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"BACKGROUND\nChronic rhinosinusitis (CRS) is a heterogeneous disease characterized by mucosal inflammation in the nose and paranasal sinuses. Inflammation in CRS is also heterogeneous and is mainly characterized by type 2 (T2) inflammation, but subsets of patients show type 1 (T1) and type 3 (T3) inflammation. Whether inflammatory endotypes are associated with clinical phenotypes has yet to be explored in detail.\n\n\nOBJECTIVE\nTo identify associations between inflammatory endotypes and clinical presentations in CRS.\n\n\nMETHODS\nWe compared 121 patients with nonpolypoid CRS (CRSsNP) and 134 patients with polypoid CRS (CRSwNP) and identified inflammatory endotypes using markers including IFN-γ (T1), eosinophil cationic protein (T2), Charcot-Leyden crystal galectin (T2), and IL-17A (T3). We collected clinical parameters from medical and surgical records and examined whether there were any associations between endotype and clinical features.\n\n\nRESULTS\nThe presence of nasal polyps, asthma comorbidity, smell loss, and allergic mucin was significantly associated with the presence of T2 endotype in all patients with CRS. The T1 endotype was significantly more common in females, and the presence of pus was significantly associated with T3 endotype in all patients with CRS. We further analyzed these associations in CRSsNP and CRSwNP separately and found that smell loss was still associated with T2 endotype and pus with the T3 endotype in both CRSsNP and CRSwNP. Importantly, patients with CRS with T2 and T3 mixed endotype tended to have clinical presentations shared by both T2 and T3 endotypes.\n\n\nCONCLUSIONS\nClinical presentations are directly associated with inflammatory endotypes in CRS. Identification of inflammatory endotypes may allow for more precise and personalized medical treatments in CRS.","claims":[{"public_id":"cl_5140eadfdf381d95a42ccaaa6f015f28","status":"active","text":"Patients with CRS with T2 and T3 mixed endotype tend to have clinical presentations shared by both T2 and T3 endotypes.","confidence":0.85,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_5140eadfdf381d95a42ccaaa6f015f28"},{"public_id":"cl_465e6f668d3451fbcd3eee645eadd46c","status":"active","text":"Smell loss is associated with T2 endotype and pus with T3 endotype in both CRSsNP and CRSwNP subgroups.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_465e6f668d3451fbcd3eee645eadd46c"},{"public_id":"cl_b49acf4366e86b2fdb7f3883c5134d8e","status":"active","text":"The T1 endotype is significantly more common in females.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b49acf4366e86b2fdb7f3883c5134d8e"},{"public_id":"cl_c17ea014893a84f9bb170e27fd7fc254","status":"active","text":"The presence of nasal polyps, asthma comorbidity, smell loss, and allergic mucin is significantly associated with the presence of T2 endotype in all patients with CRS.","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_c17ea014893a84f9bb170e27fd7fc254"},{"public_id":"cl_b885cccccf15ece3a0976cd4bdd6688e","status":"active","text":"The presence of pus is significantly associated with T3 endotype in all patients with CRS.","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b885cccccf15ece3a0976cd4bdd6688e"}],"concepts":[{"public_id":"co_2796663590688adafd553067ef6fc682","status":"active","name":"pus","description":"Purulent discharge, a clinical presentation associated with T3 endotype.","types":["clinical feature"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2796663590688adafd553067ef6fc682"},{"public_id":"co_3a34795a44d2a3f020400e3dfbbda562","status":"active","name":"nasal polyps","description":"Polypoid tissue in the nasal passages, associated with CRSwNP.","types":["clinical feature"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3a34795a44d2a3f020400e3dfbbda562"},{"public_id":"co_41b30f2c8c6b64f53a240b640f4d1e99","status":"active","name":"asthma comorbidity","description":"The presence of asthma as a comorbid condition in CRS patients.","types":["comorbidity"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_41b30f2c8c6b64f53a240b640f4d1e99"},{"public_id":"co_41db8320c42afa601fbd98b49159f6fa","status":"active","name":"T3 endotype","description":"A type 3 inflammatory endotype in CRS, identified by the marker IL-17A.","types":["endotype"],"aliases":["type 3 endotype"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_41db8320c42afa601fbd98b49159f6fa"},{"public_id":"co_5c5abd1f34eb351d777379d0d263bbec","status":"active","name":"T1 endotype","description":"A type 1 inflammatory endotype in CRS, identified by the marker IFN-γ.","types":["endotype"],"aliases":["type 1 endotype"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5c5abd1f34eb351d777379d0d263bbec"},{"public_id":"co_8cd46230384e4ebb661345ca0478864b","status":"active","name":"females","description":"Female sex, associated with higher prevalence of T1 endotype.","types":["demographic"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8cd46230384e4ebb661345ca0478864b"},{"public_id":"co_8de4a16326eb5348877ca92605991c14","status":"active","name":"allergic mucin","description":"Mucus characteristic of allergic inflammation, associated with T2 endotype.","types":["clinical feature"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8de4a16326eb5348877ca92605991c14"},{"public_id":"co_96c74756d05da6818427e90001cd2f3e","status":"active","name":"CRSsNP","description":"Nonpolypoid chronic rhinosinusitis, a clinical phenotype without nasal polyps.","types":["phenotype"],"aliases":["nonpolypoid CRS"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_96c74756d05da6818427e90001cd2f3e"},{"public_id":"co_a51ae683230810fd89a230dad89e1734","status":"active","name":"T2 endotype","description":"A type 2 inflammatory endotype in CRS, identified by markers including eosinophil cationic protein and Charcot-Leyden crystal galectin.","types":["endotype"],"aliases":["type 2 endotype"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a51ae683230810fd89a230dad89e1734"},{"public_id":"co_ac16ec774af9eda0a1a28bd335fc1490","status":"active","name":"smell loss","description":"Loss of olfactory function, a clinical presentation in CRS.","types":["symptom"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_ac16ec774af9eda0a1a28bd335fc1490"},{"public_id":"co_b8a74996cac6b070587cd23167f0bdf4","status":"active","name":"chronic rhinosinusitis","description":"A heterogeneous disease characterized by mucosal inflammation in the nose and paranasal sinuses.","types":["condition"],"aliases":["CRS"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_b8a74996cac6b070587cd23167f0bdf4"},{"public_id":"co_bb407cd647607abd9a347b0e04212a01","status":"active","name":"CRSwNP","description":"Polypoid chronic rhinosinusitis, a clinical phenotype with nasal polyps.","types":["phenotype"],"aliases":["polypoid CRS"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_bb407cd647607abd9a347b0e04212a01"},{"public_id":"co_d4a0c3aad8ef0e747ecd980cb407d7e3","status":"active","name":"mixed endotype","description":"The presence of both T2 and T3 inflammatory endotypes in the same patient.","types":["endotype"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d4a0c3aad8ef0e747ecd980cb407d7e3"}],"external_ids":{"DOI":"10.1016/j.jaip.2019.05.009","ArXiv":null,"PubMed":31128376,"PubMedCentral":"PMC6842686","MAG":2946495325,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/165163322","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":635047,"paper_uid":"f522d65a-fa88-43af-80c8-d54547ef4a4e","canonical_identity":{"paper_id":635047,"paper_uid":"f522d65a-fa88-43af-80c8-d54547ef4a4e","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/165163322"}