{"corpus_id":16873825,"paper_sha":"30a883ee3432c66d35850063af12a88684d2b356","doi":"10.1083/JCB.75.2.366","arxiv_id":null,"pmid":264115,"pmcid":"2109939","mag_id":2140517049,"dblp_id":null,"acl_id":null,"title":"Changes in thick filament length in Limulus striated muscle","year":1977,"publication_date":"1977-11-01","venue":"Journal of Cell Biology","journal":{"name":"The Journal of Cell Biology","pages":"366 - 380","volume":"75"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Biology","Medicine"],"reference_count":20,"citation_count":29,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Actin Cytoskeleton","mj":false,"qs":[{"q":"ultrastructure","mj":true,"ui":"Q000648"}],"ui":"D008841"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Cytoskeleton","mj":false,"qs":[{"q":"ultrastructure","mj":true,"ui":"Q000648"}],"ui":"D003599"},{"d":"Glycerol","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D005990"},{"d":"Horseshoe Crabs","mj":false,"ui":"D006737"},{"d":"Muscles","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":false,"ui":"Q000502"},{"q":"ultrastructure","mj":true,"ui":"Q000648"}],"ui":"D009132"},{"d":"Sarcomeres","mj":false,"qs":[{"q":"ultrastructure","mj":false,"ui":"Q000648"}],"ui":"D012518"}],"chemicals":[{"n":"Glycerol","ui":"D005990","reg":"PDC6A3C0OX"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://europepmc.org/articles/pmc2109939?pdf=render","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/30a883ee3432c66d35850063af12a88684d2b356","s2_open_access_license":"CCBYNCSA","s2_open_access_status":"GREEN","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Here we describe the change in thick filament length in striated muscle of Limulus, the horseshoe crab. Long thick filaments (4.0 microns) are isolated from living, unstimulated Limulus striated muscle while those isolated from either electrically or K+-stimulated fibers are significantly shorter (3.1 microns) (P less than 0.001). Filaments isolated from muscle glycerinated at long sarcomere lengths are long (4.4 microns) while those isolated from muscle glycerinated at short sarcomere lengths are short (2.9 microns) and the difference is significant (P less than 0.001). Thin filaments are 2.4 microns in length. The shortening of thick filaments is related to the wide range of sarcomere lengths exhibited by Limulus telson striated muscle.","claims":[{"public_id":"cl_3f3685ea2ebbabaed9a221a1e85cff24","status":"active","text":"Glycerination at long sarcomere lengths yields longer thick filaments than glycerination at short sarcomere lengths, with a significant difference between 4.4 microns and 2.9 microns.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_3f3685ea2ebbabaed9a221a1e85cff24"},{"public_id":"cl_987ca7d03d4dbf529ce12ae98da87442","status":"active","text":"The shortening of thick filaments is related to the wide range of sarcomere lengths in Limulus telson striated muscle.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_987ca7d03d4dbf529ce12ae98da87442"},{"public_id":"cl_5fa8f50f4b8586530e56921b3288f023","status":"active","text":"Thick filament length is significantly shorter after electrical or K+ stimulation, decreasing from 4.0 microns to 3.1 microns.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_5fa8f50f4b8586530e56921b3288f023"},{"public_id":"cl_490e1ee3495ad47c154131753b6b54ef","status":"active","text":"Thick filaments isolated from living, unstimulated Limulus striated muscle are longer than those isolated from electrically or K+-stimulated fibers.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_490e1ee3495ad47c154131753b6b54ef"}],"concepts":[{"public_id":"co_0c14e718e385b4e8e929a7171e82f2c4","status":"active","name":"Limulus telson striated muscle","description":"Striated muscle from the telson region of Limulus used to relate filament shortening to sarcomere length range.","types":["biological tissue"],"aliases":["telson striated muscle"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0c14e718e385b4e8e929a7171e82f2c4"},{"public_id":"co_246d1bb79e368473a3d76f634c16fcde","status":"active","name":"thin filaments","description":"The actin-containing filaments in striated muscle, reported here with a specific measured length.","types":["cellular structure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_246d1bb79e368473a3d76f634c16fcde"},{"public_id":"co_30a3bf6258b6a4bbd67a7a79b58fa712","status":"active","name":"thick filament shortening","description":"A decrease in thick filament length associated with changes in muscle state.","types":["phenomenon"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_30a3bf6258b6a4bbd67a7a79b58fa712"},{"public_id":"co_31a96dc50d28da076da5967d6dda65da","status":"active","name":"thick filament length","description":"The measured length of myosin-containing thick filaments in striated muscle.","types":["measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_31a96dc50d28da076da5967d6dda65da"},{"public_id":"co_6102565d77b10610b1352078bd2f9bf9","status":"active","name":"glycerinated muscle","description":"Muscle prepared by glycerination, a treatment used for structural analysis under different sarcomere lengths.","types":["experimental preparation"],"aliases":["muscle glycerinated"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_6102565d77b10610b1352078bd2f9bf9"},{"public_id":"co_b816f3fbace500a7c67ac1e797f36ed6","status":"active","name":"electrically or K+-stimulated fibers","description":"Muscle fibers activated either by electrical stimulation or by potassium ion (K+) stimulation.","types":["experimental condition"],"aliases":["electrically stimulated fibers","K+-stimulated fibers"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_b816f3fbace500a7c67ac1e797f36ed6"},{"public_id":"co_e47b8300dcbb11fcb2d2d11835e14ec2","status":"active","name":"Limulus striated muscle","description":"Striated muscle tissue from Limulus, the horseshoe crab, used in the measurements.","types":["biological tissue"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e47b8300dcbb11fcb2d2d11835e14ec2"},{"public_id":"co_e6aee37443d97ebf30aedbad2c40dedf","status":"active","name":"sarcomere length","description":"The length of the repeating contractile unit in striated muscle.","types":["structural parameter"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e6aee37443d97ebf30aedbad2c40dedf"}],"external_ids":{"DOI":"10.1083/JCB.75.2.366","ArXiv":null,"PubMed":264115,"PubMedCentral":"2109939","MAG":2140517049,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://europepmc.org/articles/pmc2109939?pdf=render","landing_url":"https://www.semanticscholar.org/paper/30a883ee3432c66d35850063af12a88684d2b356","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBYNCSA","status":"GREEN","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":631857,"paper_uid":"d0c5fa5d-9206-4fcf-aa48-5f3624fff253","canonical_identity":{"paper_id":631857,"paper_uid":"d0c5fa5d-9206-4fcf-aa48-5f3624fff253","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/16873825"}