{"corpus_id":17473312,"paper_sha":"e1f9d5e1b2ebbbe68490c314584ddbd5e70d5afa","doi":"10.1371/journal.pone.0046286","arxiv_id":null,"pmid":23029464,"pmcid":"3459910","mag_id":2000868408,"dblp_id":null,"acl_id":null,"title":"Toxicity Assessment of Iron Oxide Nanoparticles in Zebrafish (Danio rerio) Early Life Stages","year":2012,"publication_date":"2012-09-27","venue":"PLoS ONE","journal":{"name":"PLoS ONE","pages":null,"volume":"7"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":59,"citation_count":257,"influential_citation_count":8,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Ecotoxicology","mj":false,"ui":"D054750"},{"d":"Embryo, Nonmammalian","mj":false,"qs":[{"q":"abnormalities","mj":false,"ui":"Q000002"},{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D004625"},{"d":"Embryonic Development","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D047108"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Ferric Compounds","mj":false,"qs":[{"q":"toxicity","mj":true,"ui":"Q000633"}],"ui":"D005290"},{"d":"Nanoparticles","mj":false,"qs":[{"q":"toxicity","mj":true,"ui":"Q000633"}],"ui":"D053758"},{"d":"Water Pollutants, Chemical","mj":false,"qs":[{"q":"toxicity","mj":true,"ui":"Q000633"}],"ui":"D014874"},{"d":"Zebrafish","mj":false,"qs":[{"q":"embryology","mj":true,"ui":"Q000196"},{"q":"growth & development","mj":false,"ui":"Q000254"}],"ui":"D015027"}],"chemicals":[{"n":"Ferric Compounds","ui":"D005290","reg":"0"},{"n":"Water Pollutants, Chemical","ui":"D014874","reg":"0"},{"n":"ferric oxide","ui":"C000499","reg":"1K09F3G675"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046286&type=printable","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/e1f9d5e1b2ebbbe68490c314584ddbd5e70d5afa","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Iron oxide nanoparticles have been explored recently for their beneficial applications in many biomedical areas, in environmental remediation, and in various industrial applications. However, potential risks have also been identified with the release of nanoparticles into the environment. To study the ecological effects of iron oxide nanoparticles on aquatic organisms, we used early life stages of the zebrafish (Danio rerio) to examine such effects on embryonic development in this species. The results showed that ≥10 mg/L of iron oxide nanoparticles instigated developmental toxicity in these embryos, causing mortality, hatching delay, and malformation. Moreover, an early life stage test using zebrafish embryos/larvae is also discussed and recommended in this study as an effective protocol for assessing the potential toxicity of nanoparticles. This study is one of the first on developmental toxicity in fish caused by iron oxide nanoparticles in aquatic environments. The results will contribute to the current understanding of the potential ecotoxicological effects of nanoparticles and support the sustainable development of nanotechnology.","claims":[{"public_id":"cl_f8b77c6827dbccad8c97a127f074d6ca","status":"active","text":"An early life stage test using zebrafish embryos/larvae is recommended as an effective protocol for assessing the potential toxicity of nanoparticles.","confidence":0.85,"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale 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