{"corpus_id":19508533,"paper_sha":"da313fef6681b5c9328e49be3aedd1a0809a9b78","doi":"10.1016/j.clinbiochem.2015.07.016","arxiv_id":null,"pmid":26171975,"pmcid":null,"mag_id":777297941,"dblp_id":null,"acl_id":null,"title":"Genetic polymorphisms in the immune response: A focus on kidney transplantation.","year":2016,"publication_date":"2016-03-01","venue":"Clinical Biochemistry","journal":{"name":"Clinical biochemistry","pages":"\n          363-76\n        ","volume":"49 4-5"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":143,"citation_count":13,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Immune System","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D007107"},{"d":"Immunosuppressive Agents","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"}],"ui":"D007166"},{"d":"Kidney Transplantation","mj":true,"ui":"D016030"},{"d":"Polymorphism, Genetic","mj":true,"ui":"D011110"}],"chemicals":[{"n":"Immunosuppressive Agents","ui":"D007166","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://repositorio.uchile.cl/bitstream/2250/139250/1/Genetic-polymorphisms-in-the-immune-response.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/da313fef6681b5c9328e49be3aedd1a0809a9b78","s2_open_access_license":"CCBYNCND","s2_open_access_status":"GREEN","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The modulation of the immune system following solid organ transplantation has made considerable progress with new immunosuppressive regimens and has considerably improved rejections rates. The improvement in long-term allograft survival is, however, modest. A complex network of cytokines, chemokines, adhesion, activation and co-stimulatory molecules are the frontline contributors to allograft rejection, which in turn determines the evolution of graft function and its long-term survival. Polymorphisms in these genes influence protein levels and presumably their signaling effects. 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