{"corpus_id":19538304,"paper_sha":"495926ce298a9dc21325b085a26b5474333b5717","doi":"10.1161/HYPERTENSIONAHA.110.163014","arxiv_id":null,"pmid":21403086,"pmcid":null,"mag_id":2163665839,"dblp_id":null,"acl_id":null,"title":"Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension: Durability of Blood Pressure Reduction Out to 24 Months","year":2011,"publication_date":"2011-05-01","venue":"HYPERTENSION","journal":{"name":"Hypertension","pages":"911–917","volume":"57"},"journal_issn":null,"journal_title":null,"publication_types":["Study","JournalArticle","ClinicalTrial"],"pubmed_pub_types":["Clinical Trial","Journal Article","Multicenter Study","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine"],"reference_count":19,"citation_count":1690,"influential_citation_count":60,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Analysis of Variance","mj":false,"ui":"D000704"},{"d":"Blood Pressure","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D001794"},{"d":"Catheters","mj":false,"ui":"D057785"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Glomerular Filtration Rate","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D005919"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Hypertension","mj":false,"qs":[{"q":"drug therapy","mj":false,"ui":"Q000188"},{"q":"physiopathology","mj":false,"ui":"Q000503"},{"q":"surgery","mj":true,"ui":"Q000601"}],"ui":"D006973"},{"d":"Kidney","mj":false,"qs":[{"q":"innervation","mj":true,"ui":"Q000294"},{"q":"physiopathology","mj":false,"ui":"Q000503"},{"q":"surgery","mj":false,"ui":"Q000601"}],"ui":"D007668"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Sympathectomy","mj":false,"qs":[{"q":"instrumentation","mj":false,"ui":"Q000295"},{"q":"methods","mj":true,"ui":"Q000379"}],"ui":"D013562"},{"d":"Treatment Outcome","mj":false,"ui":"D016896"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.110.163014","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/495926ce298a9dc21325b085a26b5474333b5717","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Renal sympathetic hyperactivity is seminal in the maintenance and progression of hypertension. Catheter-based renal sympathetic denervation has been shown to significantly reduce blood pressure (BP) in patients with hypertension. Durability of effect beyond 1 year using this novel technique has never been reported. A cohort of 45 patients with resistant hypertension (systolic BP ≥160 mm Hg on ≥3 antihypertension drugs, including a diuretic) has been originally published. Herein, we report longer-term follow-up data on these and a larger group of similar patients subsequently treated with catheter-based renal denervation in a nonrandomized manner. We treated 153 patients with catheter-based renal sympathetic denervation at 19 centers in Australia, Europe, and the United States. Mean age was 57±11 years, 39% were women, 31% were diabetic, and 22% had coronary artery disease. Baseline values included mean office BP of 176/98±17/15 mm Hg, mean of 5 antihypertension medications, and an estimated glomerular filtration rate of 83±20 mL/min per 1.73 m(2). The median time from first to last radiofrequency energy ablation was 38 minutes. The procedure was without complication in 97% of patients (149 of 153). The 4 acute procedural complications included 3 groin pseudoaneurysms and 1 renal artery dissection, all managed without further sequelae. Postprocedure office BPs were reduced by 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively. In conclusion, in patients with resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in BP sustained out to ≥2 years of follow-up, without significant adverse events.","claims":[{"public_id":"cl_4f02049b6bdc35fa0f810884263f9fa6","status":"active","text":"Catheter-based renal sympathetic denervation produced substantial office blood pressure reductions that persisted through 24 months in patients with resistant hypertension.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_4f02049b6bdc35fa0f810884263f9fa6"},{"public_id":"cl_0dac13d1400886a7d8f0468881feac24","status":"active","text":"Longer-term follow-up confirmed durability of the blood pressure-lowering effect beyond one year, extending to at least two years.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_0dac13d1400886a7d8f0468881feac24"},{"public_id":"cl_71a4bcce31cc523961efb2f37e5603fd","status":"active","text":"Observed acute complications were limited to three groin pseudoaneurysms and one renal artery dissection, and all were managed without further sequelae.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_71a4bcce31cc523961efb2f37e5603fd"},{"public_id":"cl_5febba9f3dd3fc2b8fe96f7afba1c302","status":"active","text":"Procedural success was high, with the procedure being without complication in 97% of treated patients.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_5febba9f3dd3fc2b8fe96f7afba1c302"}],"concepts":[{"public_id":"co_06fa2d467824172f8fe2b00ccdece83a","status":"active","name":"durability of blood pressure reduction","description":"Persistence of the blood pressure-lowering effect over extended follow-up.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_06fa2d467824172f8fe2b00ccdece83a"},{"public_id":"co_0e2f1a6a604a8ba2951e975b27abe381","status":"active","name":"resistant hypertension","description":"Hypertension that remains uncontrolled despite treatment with multiple antihypertensive medications, including a diuretic.","types":["condition"],"aliases":["refractory hypertension"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0e2f1a6a604a8ba2951e975b27abe381"},{"public_id":"co_331f38f22251f5a7aff2dbcf8beb42a6","status":"active","name":"groin pseudoaneurysms","description":"Pseudoaneurysms occurring at the groin access site after catheter-based intervention.","types":["adverse event"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_331f38f22251f5a7aff2dbcf8beb42a6"},{"public_id":"co_61ee8c50218301961f0198a2d57e757c","status":"active","name":"longer-term follow-up","description":"Extended post-procedure observation used to assess sustained effects and safety.","types":["study 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nerves.","types":["procedure","method"],"aliases":["renal sympathetic denervation","renal denervation"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9497d5c05088bb538d43c62fcfa36eb6"},{"public_id":"co_a08011d281431ec286b00568fa910f3f","status":"active","name":"office blood pressure","description":"Blood pressure measured in the clinical office setting.","types":["measurement","outcome"],"aliases":["office BP","BP"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a08011d281431ec286b00568fa910f3f"},{"public_id":"co_c16d24ff16ef0be230e647940d260680","status":"active","name":"procedural complications","description":"Adverse events occurring during or immediately after the denervation 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