{"corpus_id":196658274,"paper_sha":"e42e7eba0c955acf8af4f5e085c615f4523da235","doi":"10.1016/J.BJP.2019.01.012","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":2951132965,"dblp_id":null,"acl_id":null,"title":"Kalanchoe laciniata and Bryophyllum pinnatum: an updated review about ethnopharmacology, phytochemistry, pharmacology and toxicology","year":2019,"publication_date":"2019-07-01","venue":"Revista Brasileira de Farmacognosia","journal":{"name":"Revista Brasileira de Farmacognosia","pages":"529-558","volume":"29"},"journal_issn":null,"journal_title":null,"publication_types":["Review"],"pubmed_pub_types":null,"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":245,"citation_count":73,"influential_citation_count":5,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The species Kalanchoe laciniata (L.) DC. and Bryophyllum pinnatum (Lam) Pers. are native from Brazil and Madagascar, respectively. Both belonging to the Crassulaceae family and being widely used by population as a natural anti-inflammatory agent. These species have similar leaf morphology and for this reason, they are known by the same popular name as “saião” or “coirama”. Several studies have been published involving different parts and preparations of these species. Therefore, this review aims to provide an update overview about the traditional uses, chemical constitution, pharmacology and toxicology of K. laciniata and B. pinnatum species. An extensive literature review was conducted in different scientific databases. Various chemical constituents have been identified in extracts from different parts of K. laciniata and B. pinnatum , being flavonoids the major compounds. They have been traditionally used to treat inflammation, microbial infection, pain, respiratory diseases, gastritis, ulcers, diabetes and cancer tumors. Non-clinical in vitro assays evaluated mainly the antimicrobial and antioxidant activities, while in vivo assays evaluated the leishmanicide, anti-inflammatory and immunomodulatory activities. Regarding toxicity, few studies have been conducted for the two species. The information reported in this work might contribute to the recognition of the importance of K. laciniata and B. pinnatum species, as well as to direct further studies.","claims":[{"public_id":"cl_7279874d9c6faeb984b86af2e3adad70","status":"active","text":"Few toxicity studies have been conducted for Kalanchoe laciniata and Bryophyllum pinnatum.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_7279874d9c6faeb984b86af2e3adad70"},{"public_id":"cl_88d0fdbbe1381719e320aa3af10792ba","status":"active","text":"Non-clinical in vitro assays mainly evaluated antimicrobial and antioxidant activities, while in vivo assays mainly evaluated leishmanicide, anti-inflammatory, and immunomodulatory activities.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_88d0fdbbe1381719e320aa3af10792ba"},{"public_id":"cl_63eb693a443d993234de803ee7f37e2d","status":"active","text":"Traditional uses of Kalanchoe laciniata and Bryophyllum pinnatum include treatment of inflammation, microbial infection, pain, respiratory diseases, gastritis, ulcers, diabetes, and cancer tumors.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_63eb693a443d993234de803ee7f37e2d"},{"public_id":"cl_ee5075308a8378cbd1fe15ba838c91ac","status":"active","text":"Various chemical constituents have been identified in extracts from different parts of Kalanchoe laciniata and Bryophyllum pinnatum, with flavonoids reported as the major compounds.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_ee5075308a8378cbd1fe15ba838c91ac"}],"concepts":[{"public_id":"co_1291f5a39310fe9ed24cbbf82f61777e","status":"active","name":"anti-inflammatory activity","description":"Activity that reduces or modulates inflammation.","types":["bioactivity"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1291f5a39310fe9ed24cbbf82f61777e"},{"public_id":"co_12d28ab56566848b67e95c275c4d23c4","status":"active","name":"chemical constitution","description":"The set of chemical constituents identified in plant extracts from the two species.","types":["chemical profile"],"aliases":["phytochemistry"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_12d28ab56566848b67e95c275c4d23c4"},{"public_id":"co_1da17712ff3a203366070b155ebc36ba","status":"active","name":"in vitro assays","description":"Laboratory experiments performed on cells, microbes, or biochemical systems outside a living organism.","types":["assay type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1da17712ff3a203366070b155ebc36ba"},{"public_id":"co_29fa70b4a07d38678c82c9cc71920a05","status":"active","name":"Kalanchoe laciniata","description":"A plant species in the Crassulaceae family discussed for its traditional uses, chemical constituents, pharmacology, and toxicology.","types":["species"],"aliases":["K. laciniata"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_29fa70b4a07d38678c82c9cc71920a05"},{"public_id":"co_60546fc963f552813e5c4541adca6525","status":"active","name":"traditional uses","description":"Reported popular or ethnomedicinal applications of the two plant species.","types":["ethnomedicinal use"],"aliases":["ethnopharmacology","folk uses"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_60546fc963f552813e5c4541adca6525"},{"public_id":"co_9bbc1d6919f600cfcf22c22b7917c507","status":"active","name":"toxicology","description":"The study of adverse effects or safety concerns associated with the two species.","types":["safety domain"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9bbc1d6919f600cfcf22c22b7917c507"},{"public_id":"co_a4c0c773c9a5aaafb57a54b3dfeba9a5","status":"active","name":"Bryophyllum pinnatum","description":"A plant species in the Crassulaceae family discussed for its traditional uses, chemical constituents, pharmacology, and toxicology.","types":["species"],"aliases":["B. pinnatum"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a4c0c773c9a5aaafb57a54b3dfeba9a5"},{"public_id":"co_b323c48cc1f731711ec8099ca2ce2b7a","status":"active","name":"in vivo assays","description":"Experiments performed in living organisms to evaluate biological effects.","types":["assay type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_b323c48cc1f731711ec8099ca2ce2b7a"},{"public_id":"co_bf3b1015855d2d6674b0949bc2384faf","status":"active","name":"flavonoids","description":"A class of plant secondary metabolites identified as major compounds in the extracts.","types":["compound class"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_bf3b1015855d2d6674b0949bc2384faf"},{"public_id":"co_ce64017b58738e6fb2dcb2bcd81c2e48","status":"active","name":"antioxidant activities","description":"Biological activities related to neutralizing oxidative processes or free radicals.","types":["bioactivity"],"aliases":["antioxidant activity"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_ce64017b58738e6fb2dcb2bcd81c2e48"},{"public_id":"co_d813ddfdc306b4115ea3d693416bd4d2","status":"active","name":"Crassulaceae family","description":"The botanical family to which Kalanchoe laciniata and Bryophyllum pinnatum belong.","types":["taxonomic family"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d813ddfdc306b4115ea3d693416bd4d2"},{"public_id":"co_e8742e010ef444ec94cd0d7a59513891","status":"active","name":"antimicrobial activity","description":"Biological activity against microorganisms such as bacteria or fungi.","types":["bioactivity"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e8742e010ef444ec94cd0d7a59513891"},{"public_id":"co_f2684c66e64aa60d9e84d1332525a9a4","status":"active","name":"immunomodulatory activity","description":"Activity that alters or regulates immune responses.","types":["bioactivity"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f2684c66e64aa60d9e84d1332525a9a4"},{"public_id":"co_fc223faf6b1626a702c2b27037b3a3de","status":"active","name":"pharmacology","description":"The biological activities assessed for extracts and preparations of the two species.","types":["biomedical domain"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_fc223faf6b1626a702c2b27037b3a3de"},{"public_id":"co_fe1eea68dbbc7cea35c841a56e629a16","status":"active","name":"leishmanicide activity","description":"Activity against Leishmania parasites.","types":["bioactivity"],"aliases":["leishmanicidal activity"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_fe1eea68dbbc7cea35c841a56e629a16"}],"external_ids":{"DOI":"10.1016/J.BJP.2019.01.012","ArXiv":null,"PubMed":null,"PubMedCentral":null,"MAG":2951132965,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/196658274","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":1},"paper_id":636814,"paper_uid":"64aa1540-e1e3-479b-bccb-e4beffd88fcb","canonical_identity":{"paper_id":636814,"paper_uid":"64aa1540-e1e3-479b-bccb-e4beffd88fcb","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/196658274"}