{"corpus_id":20018269,"paper_sha":"c58c032e6ef147f71d45d797f1566d3ed775251d","doi":"10.1371/journal.pone.0155325","arxiv_id":null,"pmid":27163931,"pmcid":"4862632","mag_id":2393888246,"dblp_id":null,"acl_id":null,"title":"Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro","year":2016,"publication_date":"2016-05-10","venue":"PLoS ONE","journal":{"name":"PLoS ONE","pages":null,"volume":"11"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","Study"],"pubmed_pub_types":["Comparative Study","Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":46,"citation_count":32,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Acetophenones","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D000098"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Anti-Inflammatory Agents","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000893"},{"d":"Berberine","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D001599"},{"d":"Biological Products","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D001688"},{"d":"Blood Platelets","mj":false,"qs":[{"q":"cytology","mj":false,"ui":"Q000166"},{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D001792"},{"d":"Caco-2 Cells","mj":false,"ui":"D018938"},{"d":"Catechin","mj":false,"qs":[{"q":"analogs & derivatives","mj":true,"ui":"Q000031"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D002392"},{"d":"Cell Line","mj":false,"ui":"D002460"},{"d":"Curcumin","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D003474"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Interleukin-6","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D015850"},{"d":"Interleukin-8","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":false,"ui":"Q000037"},{"q":"biosynthesis","mj":false,"ui":"Q000096"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D016209"},{"d":"Macrophages","mj":false,"qs":[{"q":"cytology","mj":false,"ui":"Q000166"},{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D008264"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Neutrophils","mj":false,"qs":[{"q":"cytology","mj":false,"ui":"Q000166"},{"q":"drug effects","mj":true,"ui":"Q000187"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D009504"},{"d":"Platelet Activation","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D015539"},{"d":"Pravastatin","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D017035"},{"d":"Prednisolone","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D011239"},{"d":"Primary Cell Culture","mj":false,"ui":"D061251"},{"d":"Reactive Oxygen Species","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":false,"ui":"Q000037"},{"q":"immunology","mj":false,"ui":"Q000276"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D017382"},{"d":"Stilbenes","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D013267"},{"d":"Tumor Necrosis Factor-alpha","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":false,"ui":"Q000037"},{"q":"biosynthesis","mj":false,"ui":"Q000096"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D014409"},{"d":"Interleukin-6 Inhibitors","mj":false,"ui":"D000093242"}],"chemicals":[{"n":"Acetophenones","ui":"D000098","reg":"0"},{"n":"Anti-Inflammatory Agents","ui":"D000893","reg":"0"},{"n":"Berberine","ui":"D001599","reg":"0I8Y3P32UF"},{"n":"Biological Products","ui":"D001688","reg":"0"},{"n":"Catechin","ui":"D002392","reg":"8R1V1STN48"},{"n":"Curcumin","ui":"D003474","reg":"IT942ZTH98"},{"n":"Interleukin-6","ui":"D015850","reg":"0"},{"n":"Interleukin-8","ui":"D016209","reg":"0"},{"n":"Pravastatin","ui":"D017035","reg":"KXO2KT9N0G"},{"n":"Prednisolone","ui":"D011239","reg":"9PHQ9Y1OLM"},{"n":"Reactive Oxygen Species","ui":"D017382","reg":"0"},{"n":"Stilbenes","ui":"D013267","reg":"0"},{"n":"Tumor Necrosis Factor-alpha","ui":"D014409","reg":"0"},{"n":"Interleukin-6 Inhibitors","ui":"D000093242","reg":"0"},{"n":"IL6 protein, human","ui":"C508600","reg":"0"},{"n":"pterostilbene","ui":"C107773","reg":"26R60S6A5I"},{"n":"paeonol","ui":"C013638","reg":"3R834EPI82"},{"n":"acetovanillone","ui":"C056165","reg":"B6J7B9UDTR"},{"n":"epigallocatechin gallate","ui":"C045651","reg":"BQM438CTEL"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155325&type=printable","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/c58c032e6ef147f71d45d797f1566d3ed775251d","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Inflammation is an important therapeutic target. Due to their potency, steroidal drugs dominate the current treatment of inflammatory disorders. However, steroidal drugs can also exert a broad range of side effects and appear not always effective. This calls for the development of alternative drugs with a different mechanism of action, which are likely to be found in the field of natural products (NPs). For many NPs strong anti-inflammatory effects have been described, but usually investigating a single compound in a single assay. In this study, eight promising NPs were selected and tested against the strong anti-inflammatory drug prednisolone. For this head-to-head comparison, in vitro assays were used which represent different pathways of the inflammatory response: TNF-α and IL-6 expression by macrophages, IL-8 expression by colon epithelial cells, ROS production in polymorphonuclear leukocytes and platelet activation in whole blood. Performance profiles were established which allowed us to identify curcumin, berberine chloride and epigallocatechin gallate as potential alternatives for prednisolone or other glucocorticoids in inflammation.","claims":[{"public_id":"cl_355335fbc94f3c87935fd4ba2ab89f4b","status":"active","text":"Eight promising natural products were tested head-to-head against prednisolone in vitro across multiple inflammatory-response assays.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_355335fbc94f3c87935fd4ba2ab89f4b"},{"public_id":"cl_db768952695c02cbb50162fb34c83604","status":"active","text":"Performance profiles across TNF-α and IL-6 expression, IL-8 expression, ROS production, and platelet activation identified curcumin, berberine chloride, and epigallocatechin gallate as potential alternatives to prednisolone or other glucocorticoids in inflammation.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_db768952695c02cbb50162fb34c83604"}],"concepts":[{"public_id":"co_01417d2e5022faf56e7526afb5e1e9eb","status":"active","name":"natural products","description":"Naturally derived compounds evaluated here for anti-inflammatory activity.","types":["compound class"],"aliases":["NPs"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_01417d2e5022faf56e7526afb5e1e9eb"},{"public_id":"co_5b2fa087896677e77b409ca09544546f","status":"active","name":"in vitro assays","description":"Laboratory assays performed outside living organisms to measure inflammatory-response pathways.","types":["method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5b2fa087896677e77b409ca09544546f"},{"public_id":"co_6a82c66b64813ae0054978e55a7866f1","status":"active","name":"ROS production","description":"Generation of reactive oxygen species, measured here in polymorphonuclear leukocytes as an inflammatory readout.","types":["biological assay endpoint"],"aliases":["reactive oxygen species production"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_6a82c66b64813ae0054978e55a7866f1"},{"public_id":"co_841b7e6ca02abb08406e2555c7834c03","status":"active","name":"prednisolone","description":"A glucocorticoid drug used here as the reference anti-inflammatory comparator.","types":["drug","comparator"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_841b7e6ca02abb08406e2555c7834c03"},{"public_id":"co_8fffad3d8c48f8208f5de000d5be39f6","status":"active","name":"epigallocatechin gallate","description":"A catechin from tea evaluated for anti-inflammatory performance in the comparison.","types":["compound"],"aliases":["EGCG"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8fffad3d8c48f8208f5de000d5be39f6"},{"public_id":"co_90138606e9b9f5bacd05e4007ee131e1","status":"active","name":"berberine chloride","description":"A natural product alkaloid salt evaluated for anti-inflammatory performance in the comparison.","types":["compound"],"aliases":["berberine HCl"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_90138606e9b9f5bacd05e4007ee131e1"},{"public_id":"co_bd6fc48ae733ea5f416b4e5f42eae2cb","status":"active","name":"IL-8 expression","description":"Expression of interleukin 8, measured in colon epithelial cells as an inflammation-related readout.","types":["biological assay endpoint"],"aliases":["interleukin-8 expression"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_bd6fc48ae733ea5f416b4e5f42eae2cb"},{"public_id":"co_d2ac6f86fef36d5f67ff56ef4f998a01","status":"active","name":"curcumin","description":"A natural product compound evaluated for anti-inflammatory performance in the comparison.","types":["compound"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d2ac6f86fef36d5f67ff56ef4f998a01"},{"public_id":"co_d9657df29da1b21716ab9c122a42abf0","status":"active","name":"platelet activation","description":"Activation of platelets measured in whole blood as part of the inflammatory-response profiling.","types":["biological assay endpoint"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d9657df29da1b21716ab9c122a42abf0"},{"public_id":"co_e5f754650536a0b725d68f0ee262221e","status":"active","name":"TNF-α expression","description":"Expression of tumor necrosis factor alpha, measured in macrophages as an inflammation-related readout.","types":["biological assay endpoint"],"aliases":["TNF-alpha expression"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e5f754650536a0b725d68f0ee262221e"},{"public_id":"co_f3f85fb879051a5ccf8078b154f1c7b6","status":"active","name":"IL-6 expression","description":"Expression of interleukin 6, measured in macrophages as an inflammation-related readout.","types":["biological assay endpoint"],"aliases":["interleukin-6 expression"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f3f85fb879051a5ccf8078b154f1c7b6"}],"external_ids":{"DOI":"10.1371/journal.pone.0155325","ArXiv":null,"PubMed":27163931,"PubMedCentral":"4862632","MAG":2393888246,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155325&type=printable","landing_url":"https://www.semanticscholar.org/paper/c58c032e6ef147f71d45d797f1566d3ed775251d","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":632907,"paper_uid":"557b64c3-03ba-4d93-8365-1df1a620ddda","canonical_identity":{"paper_id":632907,"paper_uid":"557b64c3-03ba-4d93-8365-1df1a620ddda","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/20018269"}