{"corpus_id":20380055,"paper_sha":"cdf4963decb891a00d9b88beb3a45b8c0bd4a57a","doi":"10.1155/2016/7068287","arxiv_id":null,"pmid":27073297,"pmcid":"4814687","mag_id":2297903115,"dblp_id":null,"acl_id":null,"title":"Differential Recruitment of Dendritic Cells Subsets to Lymph Nodes Correlates with a Protective or Permissive T-Cell Response during Leishmania (Viannia) Braziliensis or Leishmania (Leishmania) Amazonensis Infection","year":2016,"publication_date":"2016-03-17","venue":"Mediators of Inflammation","journal":{"name":"Mediators of Inflammation","pages":null,"volume":"2016"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":42,"citation_count":18,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"CD4-Positive T-Lymphocytes","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D015496"},{"d":"CD8-Positive T-Lymphocytes","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D018414"},{"d":"Dendritic Cells","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D003713"},{"d":"Flow Cytometry","mj":false,"ui":"D005434"},{"d":"Interferon-gamma","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D007371"},{"d":"Interleukin-10","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D016753"},{"d":"Interleukin-4","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D015847"},{"d":"Leishmania","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"},{"q":"pathogenicity","mj":true,"ui":"Q000472"}],"ui":"D007891"},{"d":"Leishmania braziliensis","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"},{"q":"pathogenicity","mj":true,"ui":"Q000472"}],"ui":"D007892"},{"d":"Lymph Nodes","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008198"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Mice, Inbred BALB C","mj":false,"ui":"D008807"}],"chemicals":[{"n":"Interleukin-10","ui":"D016753","reg":"130068-27-8"},{"n":"Interleukin-4","ui":"D015847","reg":"207137-56-2"},{"n":"Interferon-gamma","ui":"D007371","reg":"82115-62-6"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://downloads.hindawi.com/journals/mi/2016/7068287.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/cdf4963decb891a00d9b88beb3a45b8c0bd4a57a","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Leishmania (L.) amazonensis (La) and L. (V.) braziliensis (Lb) are responsible for a large clinical and immunopathological spectrum in human disease; while La may be responsible for anergic disease, Lb infection leads to cellular hypersensitivity. To better understand the dichotomy in the immune response caused by these Leishmania species, we evaluated subsets of dendritic cells (DCs) and T lymphocyte in draining lymph nodes during the course of La and Lb infection in BALB/c mice. Our results demonstrated a high involvement of DCs in La infection, which was characterized by the greater accumulation of Langerhans cells (LCs); conversely, Lb infection led to an increase in dermal DCs (dDCs) throughout the infection. Considering the T lymphocyte response, an increase of effector, activated, and memory CD4+ T-cells was observed in Lb infection. Interleukin- (IL-) 4- and IL-10-producing CD4+and CD8+ T-cells were present in both La and Lb infection; however, interferon- (IFN-) γ-producing CD4+and CD8+ T-cells were detected only in Lb infection. The results suggest that during Lb infection, the dDCs were the predominant subset of DCs that in turn was associated with the development of Th1 immune response; in contrast La infection was associated with a preferential accumulation of LCs and total blockage of the development of Th1 immune response.","claims":[{"public_id":"cl_0228a40504aa93aa6fff50ecc7b5c4bc","status":"active","text":"During Leishmania (V.) braziliensis infection, dermal dendritic cells are the predominant dendritic cell subset and are associated with development of a Th1 immune response; in contrast, Leishmania (L.) amazonensis infection is associated with preferential accumulation of Langerhans cells and total blockage of Th1 immune response development.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_0228a40504aa93aa6fff50ecc7b5c4bc"},{"public_id":"cl_f269cb8f958789667d196ecafafe5fe0","status":"active","text":"Interleukin-4- and interleukin-10-producing CD4+ and CD8+ T-cells are present in both Leishmania (L.) amazonensis and Leishmania (V.) braziliensis infection.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_f269cb8f958789667d196ecafafe5fe0"},{"public_id":"cl_fa455c5cb6470967435c2e4079e89e07","status":"active","text":"Leishmania (L.) amazonensis infection in BALB/c mice leads to greater accumulation of Langerhans cells (LCs) in draining lymph nodes, whereas Leishmania (V.) braziliensis infection leads to an increase in dermal dendritic cells (dDCs).","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_fa455c5cb6470967435c2e4079e89e07"},{"public_id":"cl_26ab53d6402b60f498497d8359632152","status":"active","text":"Leishmania (V.) braziliensis infection in BALB/c mice results in an increase of effector, activated, and memory CD4+ T-cells, and interferon-γ-producing CD4+ and CD8+ T-cells are detected only in Lb infection.","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_26ab53d6402b60f498497d8359632152"}],"concepts":[{"public_id":"co_1195f3b0cfe06a6d11d83392d4b78dc4","status":"active","name":"interferon-γ-producing T-cells","description":"T cells that produce interferon-γ, detected only in Leishmania (V.) braziliensis infection.","types":["cell type"],"aliases":["IFN-γ-producing T-cells"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_1195f3b0cfe06a6d11d83392d4b78dc4"},{"public_id":"co_20f62f682c31ef73da437b87f183ef62","status":"active","name":"interleukin-4-producing T-cells","description":"T cells that produce interleukin-4, present in both La and Lb infection.","types":["cell type"],"aliases":["IL-4-producing T-cells"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_20f62f682c31ef73da437b87f183ef62"},{"public_id":"co_3b302ebc59b949dc6a17601bf3462507","status":"active","name":"Langerhans cells","description":"A subset of dendritic cells that accumulate in draining lymph nodes during Leishmania (L.) amazonensis infection.","types":["cell type"],"aliases":["LCs"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_3b302ebc59b949dc6a17601bf3462507"},{"public_id":"co_45221ddf90f8091980f80199fe36a89b","status":"active","name":"dermal dendritic cells","description":"A subset of dendritic cells that increase in draining lymph nodes during Leishmania (V.) braziliensis infection.","types":["cell type"],"aliases":["dDCs"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_45221ddf90f8091980f80199fe36a89b"},{"public_id":"co_594d42f35c7affd43abebfa91e699383","status":"active","name":"Leishmania (V.) braziliensis","description":"A Leishmania species responsible for cellular hypersensitivity in humans, studied here in BALB/c mice.","types":["organism"],"aliases":["Lb"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_594d42f35c7affd43abebfa91e699383"},{"public_id":"co_5b0a1101950f11a291092d567dbdd4f5","status":"active","name":"CD4+ T-cells","description":"T lymphocytes expressing CD4, including effector, activated, and memory subsets, increased in Lb infection.","types":["cell type"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_5b0a1101950f11a291092d567dbdd4f5"},{"public_id":"co_a52e25a5322aa9d8aeb13158a714a943","status":"active","name":"draining lymph nodes","description":"Lymph nodes that drain the infection site, where dendritic cell subsets and T lymphocytes were evaluated.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_a52e25a5322aa9d8aeb13158a714a943"},{"public_id":"co_d7a223998d09572f587136663a79475f","status":"active","name":"interleukin-10-producing T-cells","description":"T cells that produce interleukin-10, present in both La and Lb infection.","types":["cell type"],"aliases":["IL-10-producing T-cells"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_d7a223998d09572f587136663a79475f"},{"public_id":"co_fdc57b01fde4b00b418f3cc93e558667","status":"active","name":"Leishmania (L.) amazonensis","description":"A Leishmania species responsible for anergic disease in humans, studied here in BALB/c mice.","types":["organism"],"aliases":["La"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_fdc57b01fde4b00b418f3cc93e558667"},{"public_id":"co_ffa9c5c594a5b1559b51db9ff2f6a3f8","status":"active","name":"Th1 immune response","description":"A type of T-helper immune response associated with dermal dendritic cells in Lb infection and blocked in La infection.","types":["immune response"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_ffa9c5c594a5b1559b51db9ff2f6a3f8"}],"external_ids":{"DOI":"10.1155/2016/7068287","ArXiv":null,"PubMed":27073297,"PubMedCentral":"4814687","MAG":2297903115,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://downloads.hindawi.com/journals/mi/2016/7068287.pdf","landing_url":"https://www.semanticscholar.org/paper/cdf4963decb891a00d9b88beb3a45b8c0bd4a57a","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":638364,"paper_uid":"fb7cb6c4-1068-4cf0-9fd8-1a0ed3138e94","canonical_identity":{"paper_id":638364,"paper_uid":"fb7cb6c4-1068-4cf0-9fd8-1a0ed3138e94","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/20380055"}