{"corpus_id":203861422,"paper_sha":"4480b9f225b0e3cbaa8a1160b87fae1824ba251f","doi":"10.2460/ajvr.1982.43.04.594","arxiv_id":null,"pmid":7073079,"pmcid":null,"mag_id":2408963925,"dblp_id":null,"acl_id":null,"title":"Effect of intra-articular injection of orgotein and saline solution on equine synovia.","year":1982,"publication_date":"1982-04-01","venue":"American Journal of Veterinary Research","journal":{"name":"American journal of veterinary research","pages":"\n          594-7\n        ","volume":"43 4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":0,"citation_count":33,"influential_citation_count":1,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Anti-Inflammatory Agents","mj":false,"qs":[{"q":"administration & dosage","mj":true,"ui":"Q000008"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D000893"},{"d":"Carpal Bones","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002348"},{"d":"Horses","mj":true,"ui":"D006736"},{"d":"Injections, Intra-Articular","mj":false,"ui":"D007270"},{"d":"Joints","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D007596"},{"d":"Leukocyte Count","mj":false,"qs":[{"q":"veterinary","mj":false,"ui":"Q000662"}],"ui":"D007958"},{"d":"Metalloproteins","mj":false,"qs":[{"q":"administration & dosage","mj":true,"ui":"Q000008"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D008667"},{"d":"Proteins","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D011506"},{"d":"Sodium Chloride","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D012965"},{"d":"Synovial Fluid","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D013582"}],"chemicals":[{"n":"Anti-Inflammatory Agents","ui":"D000893","reg":"0"},{"n":"Metalloproteins","ui":"D008667","reg":"0"},{"n":"Proteins","ui":"D011506","reg":"0"},{"n":"Sodium Chloride","ui":"D012965","reg":"451W47IQ8X"},{"n":"orgotein","ui":"C005180","reg":"PKE82W49V1"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Orgotein was injected into the right intercarpal joint of each of 8 horses; the corresponding left joint was left alone (not injected) or was given an injection of normal saline solution. Injection with orgotein caused a transient, marked inflammatory response, evidenced by clinical signs and by increased leukocytes and total protein in the synovia (synovial fluid). Leukocyte numbers and total protein concentration were increased (P less than 0.010) in the orgotein-injected joints within 24 hours. However, saline solution alone also elicited a marked inflammatory response, manifested by increased leukocyte count and total protein concentration. By 7 days, leukocyte and total protein values had returned to approximately base line in all joints.","claims":[{"public_id":"cl_303c1f6af9d220c727a460d9ba1ae04c","status":"active","text":"Leukocyte and total protein values returned to approximately baseline in all joints by 7 days.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_303c1f6af9d220c727a460d9ba1ae04c"},{"public_id":"cl_bfa0952b96d20e2236a39c24533b974b","status":"active","text":"Normal saline solution injection also elicited a marked inflammatory response, including increased leukocyte count and total protein concentration.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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