{"corpus_id":20437496,"paper_sha":"36ccc4d0d5870449ea2fa12c481390051773ef3c","doi":"10.3390/molecules17032704","arxiv_id":null,"pmid":22391603,"pmcid":"6268287","mag_id":2108319118,"dblp_id":null,"acl_id":null,"title":"Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components","year":2012,"publication_date":"2012-03-01","venue":"Molecules","journal":{"name":"Molecules","pages":"2704 - 2713","volume":"17"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","Study"],"pubmed_pub_types":["Comparative Study","Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":20,"citation_count":272,"influential_citation_count":9,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Anti-Bacterial Agents","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000900"},{"d":"Antineoplastic Agents, Phytogenic","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000972"},{"d":"Bacteria","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D001419"},{"d":"Bicyclic Monoterpenes","mj":false,"ui":"D000081008"},{"d":"Bridged Bicyclo Compounds","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D001643"},{"d":"Cell Line, Tumor","mj":false,"ui":"D045744"},{"d":"Cell Survival","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002470"},{"d":"Cyclohexanols","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D003511"},{"d":"Drug Screening Assays, Antitumor","mj":false,"ui":"D004354"},{"d":"Eucalyptol","mj":false,"ui":"D000077591"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Inhibitory Concentration 50","mj":false,"ui":"D020128"},{"d":"Microbial Sensitivity Tests","mj":false,"ui":"D008826"},{"d":"Monoterpenes","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D039821"},{"d":"Oils, Volatile","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D009822"},{"d":"Plant Extracts","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010936"},{"d":"Rosmarinus","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"}],"ui":"D027542"}],"chemicals":[{"n":"Anti-Bacterial Agents","ui":"D000900","reg":"0"},{"n":"Antineoplastic Agents, Phytogenic","ui":"D000972","reg":"0"},{"n":"Bicyclic Monoterpenes","ui":"D000081008","reg":"0"},{"n":"Bridged Bicyclo Compounds","ui":"D001643","reg":"0"},{"n":"Cyclohexanols","ui":"D003511","reg":"0"},{"n":"Monoterpenes","ui":"D039821","reg":"0"},{"n":"Oils, Volatile","ui":"D009822","reg":"0"},{"n":"Plant Extracts","ui":"D010936","reg":"0"},{"n":"beta-pinene","ui":"C010789","reg":"4MS8VHZ1HJ"},{"n":"alpha-pinene","ui":"C005451","reg":"JPF3YI7O34"},{"n":"Eucalyptol","ui":"D000077591","reg":"RV6J6604TK"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.mdpi.com/1420-3049/17/3/2704/pdf?version=1403113493","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/36ccc4d0d5870449ea2fa12c481390051773ef3c","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.","claims":[{"public_id":"cl_74fe47f5eb7e9def99d69fac34015694","status":"active","text":"Cytotoxicity of all test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402.","confidence":0.93,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_74fe47f5eb7e9def99d69fac34015694"},{"public_id":"cl_e7641389e05e0d7865466f5ba6f580ce","status":"active","text":"Rosmarinus officinalis L. essential oil exhibited the strongest cytotoxicity toward SK-OV-3, HO-8910, and Bel-7402 human cancer cells, with IC50 values of 0.025‰, 0.076‰, and 0.13‰ (v/v), respectively.","confidence":0.95,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_e7641389e05e0d7865466f5ba6f580ce"},{"public_id":"cl_7c0503d0fa0cad7308b7876a18e86278","status":"active","text":"Rosmarinus officinalis L. essential oil possessed similar antibacterial activities to α-pinene and better antibacterial activities than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities among the tested components.","confidence":0.92,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri (gsgmdx9r6e)","roles":["extraction"],"url":"https://sah.borca.ai/u/gsgmdx9r6e"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_7c0503d0fa0cad7308b7876a18e86278"},{"public_id":"cl_231adeb106fc8c87530aabcc2926410e","status":"active","text":"Rosmarinus officinalis L. essential oil showed greater activity than its isolated components in both antibacterial and anticancer test systems, with activities mostly related to concentration.","confidence":0.88,"contributors":[{"id":170,"public_id":"gsgmdx9r6e","public_label":"pupuri 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