{"corpus_id":205671753,"paper_sha":"272d24317def219cbac05581a1c5b0c4281af480","doi":"10.1016/j.jalz.2016.02.002","arxiv_id":null,"pmid":27012484,"pmcid":"PMC6417794","mag_id":2309442902,"dblp_id":null,"acl_id":null,"title":"Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria","year":2016,"publication_date":"2016-03-01","venue":"Alzheimer's & Dementia","journal":{"name":"Alzheimer's & Dementia","pages":null,"volume":"12"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Review"],"s2_fields_of_study":["Medicine"],"reference_count":310,"citation_count":1680,"influential_citation_count":42,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Alzheimer Disease","mj":false,"qs":[{"q":"diagnosis","mj":true,"ui":"Q000175"},{"q":"diagnostic imaging","mj":false,"ui":"Q000000981"},{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"physiopathology","mj":true,"ui":"Q000503"}],"ui":"D000544"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Brain","mj":false,"qs":[{"q":"diagnostic imaging","mj":false,"ui":"Q000000981"},{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D001921"},{"d":"Disease Progression","mj":false,"ui":"D018450"},{"d":"Humans","mj":false,"ui":"D006801"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://europepmc.org/articles/pmc6417794?pdf=render","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/272d24317def219cbac05581a1c5b0c4281af480","s2_open_access_license":null,"s2_open_access_status":"GREEN","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this \"silent\" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. 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