{"corpus_id":206530366,"paper_sha":"406de049a6aabf90933e796d6cbc7754dcf1fd4f","doi":"10.1016/j.ccep.2015.10.036","arxiv_id":null,"pmid":26920201,"pmcid":null,"mag_id":null,"dblp_id":null,"acl_id":null,"title":"Brugada Syndrome.","year":2016,"publication_date":null,"venue":"Cardiac Electrophysiology Clinics","journal":{"name":"Cardiac electrophysiology clinics","pages":"\n          239-45\n        ","volume":"8 1"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle","CaseReport"],"pubmed_pub_types":["Case Reports","Journal Article","Review"],"s2_fields_of_study":["Medicine"],"reference_count":39,"citation_count":5,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Brugada Syndrome","mj":true,"ui":"D053840"},{"d":"Defibrillators, Implantable","mj":false,"ui":"D017147"},{"d":"Electrocardiography","mj":false,"ui":"D004562"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"NAV1.5 Voltage-Gated Sodium Channel","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D062554"}],"chemicals":[{"n":"NAV1.5 Voltage-Gated Sodium Channel","ui":"D062554","reg":"0"},{"n":"SCN5A protein, human","ui":"C568320","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Brugada syndrome might stay undetected in patients until surviving cardiac arrest. Despite the prominent advances in exploring the disease in the past 2 decades, many questions remain unanswered and the controversies continue. Despite all mutations identified to be associated with the disease, two-thirds of cases have a negative genetic test. Future studies should be more directed on modulating factors and their impact on patients' risk for sudden death to help physicians in risk stratifying their patients and optimally implementing an implantable cardioverter defibrillator to prevent sudden cardiac death.","claims":[{"public_id":"cl_22a8fa9f8be6150e7b253e1bb273c70a","status":"active","text":"Brugada syndrome may remain undetected until a patient survives cardiac arrest.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_22a8fa9f8be6150e7b253e1bb273c70a"},{"public_id":"cl_e8f4265cd86f63f0758c24c8f9fdabce","status":"active","text":"Modulating factors and their impact on sudden-death risk are key targets for improving risk stratification in patients with Brugada syndrome.","confidence":0.88,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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