{"corpus_id":206614311,"paper_sha":"7ffdaa399d916c9091de4d782d7df481b457c7c5","doi":"10.1177/1010428317711311","arxiv_id":null,"pmid":28639907,"pmcid":null,"mag_id":2673362053,"dblp_id":null,"acl_id":null,"title":"Ferrichrome identified from Lactobacillus casei ATCC334 induces apoptosis through its iron-binding site in gastric cancer cells","year":2017,"publication_date":"2017-06-01","venue":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine","journal":{"name":"Tumor Biology","pages":null,"volume":"39"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":28,"citation_count":21,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Apoptosis","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D017209"},{"d":"Binding Sites","mj":false,"ui":"D001665"},{"d":"Caspase 9","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"}],"ui":"D053453"},{"d":"Cell Line, Tumor","mj":false,"ui":"D045744"},{"d":"Ferrichrome","mj":false,"qs":[{"q":"administration & dosage","mj":true,"ui":"Q000008"},{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"isolation & purification","mj":false,"ui":"Q000302"}],"ui":"D005291"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Iron","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D007501"},{"d":"Lacticaseibacillus casei","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D007780"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Molecular Docking Simulation","mj":false,"ui":"D062105"},{"d":"Stomach Neoplasms","mj":false,"qs":[{"q":"drug therapy","mj":true,"ui":"Q000188"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D013274"},{"d":"Xenograft Model Antitumor Assays","mj":false,"ui":"D023041"}],"chemicals":[{"n":"Ferrichrome","ui":"D005291","reg":"15630-64-5"},{"n":"Iron","ui":"D007501","reg":"E1UOL152H7"},{"n":"Caspase 9","ui":"D053453","reg":"EC 3.4.22.-"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1010428317711311","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/7ffdaa399d916c9091de4d782d7df481b457c7c5","s2_open_access_license":"CCBYNC","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Ferrichrome is known to be a siderophore, but it was recently identified as a tumor-suppressive molecule derived from Lactobacillus casei ATCC334 (L. casei). In the present study, we investigated the effects of ferrichrome in gastric cancer cells. Cell lines and xenograft models treated with ferrichrome demonstrated growth suppression. The expression levels of cleaved poly (adenosine diphosphate-ribose) polymerase, and cleaved caspase-9 were increased by ferrichrome treatment. Although the tumor-suppressive effects of ferrichrome were almost completely diminished by the iron chelation, the reduction in the intracellular iron by ferrichrome did not correlate with its tumor-suppressive effects. An exhaustive docking simulation indicated that iron-free ferrichrome can make stable conformations with various mammalian molecules, including transporters and receptors. In conclusion, probiotic-derived ferrichrome induced apoptosis in gastric cancer cells. The iron binding site of ferrichrome is the structure responsible for its tumor suppressive function.","claims":[{"public_id":"cl_a2100a4c86301f49660881ac187c4d0e","status":"active","text":"Ferrichrome suppresses growth in gastric cancer cell lines and xenograft models.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a2100a4c86301f49660881ac187c4d0e"},{"public_id":"cl_65222528351ca7f7e4288bef0fc6708a","status":"active","text":"Ferrichrome treatment increases cleaved poly(adenosine diphosphate-ribose) polymerase and cleaved caspase-9 expression, consistent with apoptosis induction.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_65222528351ca7f7e4288bef0fc6708a"},{"public_id":"cl_2b69ac13af407e202cb87e8c18d0a56c","status":"active","text":"Ferrichrome's tumor-suppressive effects are largely lost after iron chelation, but its reduction of intracellular iron does not correlate with those effects.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_2b69ac13af407e202cb87e8c18d0a56c"},{"public_id":"cl_a57fd668a0fd9ab717a9bc75ac49be29","status":"active","text":"The iron-binding site of ferrichrome is responsible for its tumor-suppressive function in gastric cancer cells.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a57fd668a0fd9ab717a9bc75ac49be29"}],"concepts":[{"public_id":"co_0b864b5c2c76528e89ca2702739a0856","status":"active","name":"iron chelation","description":"Removal or sequestration of iron used to test whether ferrichrome activity depends on iron binding.","types":["experimental manipulation"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0b864b5c2c76528e89ca2702739a0856"},{"public_id":"co_1e697716d46f72afe2c1b322824c3058","status":"active","name":"ferrichrome","description":"A probiotic-derived siderophore from Lactobacillus casei ATCC334 studied for anti-tumor activity.","types":["molecule"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1e697716d46f72afe2c1b322824c3058"},{"public_id":"co_4af00b1e78eb050190a50dba6f6be575","status":"active","name":"Lactobacillus casei ATCC334","description":"A bacterial strain that produces ferrichrome.","types":["bacterial strain"],"aliases":["L. casei ATCC334","L. casei"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4af00b1e78eb050190a50dba6f6be575"},{"public_id":"co_54775c073e6de7d97024a6f47effcb21","status":"active","name":"gastric cancer cells","description":"Cancer cell models derived from gastric tumors used to test ferrichrome effects.","types":["cell model"],"aliases":["gastric cancer cell lines"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_54775c073e6de7d97024a6f47effcb21"},{"public_id":"co_6a9c08fec16d5157c25589efd5ce1962","status":"active","name":"xenograft models","description":"In vivo tumor models used to assess the growth effects of ferrichrome.","types":["animal model"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_6a9c08fec16d5157c25589efd5ce1962"},{"public_id":"co_87412458bc746f3e7306a7dc93431ca4","status":"active","name":"iron-binding site","description":"The structural region of ferrichrome that binds iron.","types":["molecular structure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_87412458bc746f3e7306a7dc93431ca4"},{"public_id":"co_878dbeeb122432c8730f5dc9cd01b49a","status":"active","name":"cleaved poly(adenosine diphosphate-ribose) polymerase","description":"A cleaved apoptotic marker measured after ferrichrome treatment.","types":["biomarker"],"aliases":["cleaved PARP"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_878dbeeb122432c8730f5dc9cd01b49a"},{"public_id":"co_88bddaeaa918728d03ac912ec6e4a80a","status":"active","name":"apoptosis","description":"Programmed cell death pathway assessed as a mechanism of ferrichrome action.","types":["cell death process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_88bddaeaa918728d03ac912ec6e4a80a"},{"public_id":"co_8b9971154fd5f205f6e7bdba8a22f656","status":"active","name":"intracellular iron","description":"The amount of iron inside cells measured in relation to ferrichrome's effects.","types":["molecular measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8b9971154fd5f205f6e7bdba8a22f656"},{"public_id":"co_d898db965eb501637d393f87d4954aa5","status":"active","name":"cleaved caspase-9","description":"An activated apoptosis-related protease measured after ferrichrome treatment.","types":["biomarker"],"aliases":["activated caspase-9"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d898db965eb501637d393f87d4954aa5"}],"external_ids":{"DOI":"10.1177/1010428317711311","ArXiv":null,"PubMed":28639907,"PubMedCentral":null,"MAG":2673362053,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/1010428317711311","landing_url":"https://www.semanticscholar.org/paper/7ffdaa399d916c9091de4d782d7df481b457c7c5","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBYNC","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":632376,"paper_uid":"31afdefb-04f0-4ccd-98d3-c3a0957ad6de","canonical_identity":{"paper_id":632376,"paper_uid":"31afdefb-04f0-4ccd-98d3-c3a0957ad6de","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/206614311"}