{"corpus_id":206801262,"paper_sha":"0644fdabcb0866983cc86245066fee12d6c9becf","doi":"10.1016/j.maturitas.2014.12.003","arxiv_id":null,"pmid":25637957,"pmcid":null,"mag_id":1963817121,"dblp_id":null,"acl_id":null,"title":"Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis.","year":2015,"publication_date":"2015-03-01","venue":"Maturitas","journal":{"name":"Maturitas","pages":"\n          237-44\n        ","volume":"80 3"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":103,"citation_count":211,"influential_citation_count":4,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Cartilage, Articular","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D002358"},{"d":"Cellular Senescence","mj":false,"ui":"D016922"},{"d":"Chondrocytes","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D019902"},{"d":"Disease Progression","mj":false,"ui":"D018450"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Osteoarthritis","mj":false,"qs":[{"q":"etiology","mj":false,"ui":"Q000209"},{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D010003"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Aging and inflammation are major contributing factors to the development and progression of arthritic and musculoskeletal diseases. \"Inflammaging\" refers to low-grade inflammation that occurs during physiological aging. In this paper we review the published literature on cartilage aging and propose the term \"chondrosenescence\" to define the age-dependent deterioration of chondrocyte function and how it undermines cartilage function in osteoarthritis. We propose the concept that a small number of senescent chondrocytes may be able to take advantage of the inflammatory tissue microenvironment and the inflammaging and immunosenescence that is concurrently occurring in the arthritic joint, further contributing to the age-related degradation of articular cartilage, subchondral bone, synovium and other tissues. In this new framework \"chondrosenescence\" is intimately linked with inflammaging and the disturbed interplay between autophagy and inflammasomes, thus contributing to the age-related increase in the prevalence of osteoarthritis and a decrease in the efficacy of articular cartilage repair. A better understanding of the basic mechanisms underlying chondrosenescence and its modification by drugs, weight loss, improved nutrition and physical exercise could lead to the development of new therapeutic and preventive strategies for osteoarthritis and a range of other age-related inflammatory joint diseases. Aging is inevitable but age-related diseases may be modifiable.","claims":[{"public_id":"cl_0348cbc670d8b6d48db310f925dd153a","status":"active","text":"A small number of senescent chondrocytes may exploit the inflammatory tissue microenvironment together with inflammaging and immunosenescence in the arthritic joint, contributing to age-related degradation of articular cartilage, subchondral bone, synovium, and other tissues.","confidence":0.88,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_0348cbc670d8b6d48db310f925dd153a"},{"public_id":"cl_b9e182dd2e7a50ac1874cba195fbe15a","status":"active","text":"Better understanding of the mechanisms underlying chondrosenescence and its modification by drugs, weight loss, improved nutrition, and physical exercise could support new therapeutic and preventive strategies for osteoarthritis and other age-related inflammatory joint diseases.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b9e182dd2e7a50ac1874cba195fbe15a"},{"public_id":"cl_5025ea2fb468c4487f8f79a77819613f","status":"active","text":"Chondrosenescence is linked with inflammaging and disturbed interplay between autophagy and inflammasomes, helping explain the age-related increase in osteoarthritis prevalence and reduced efficacy of articular cartilage repair.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_5025ea2fb468c4487f8f79a77819613f"},{"public_id":"cl_ab9170b19c269f273952bc676525f956","status":"active","text":"Chondrosenescence is proposed as the term for the age-dependent deterioration of chondrocyte function that undermines cartilage function in osteoarthritis.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_ab9170b19c269f273952bc676525f956"}],"concepts":[{"public_id":"co_04cbb7f60c6b137125bb541cee509f9f","status":"active","name":"age-related inflammatory joint diseases","description":"Inflammatory disorders of joints whose occurrence or severity increases with age.","types":["disease category"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_04cbb7f60c6b137125bb541cee509f9f"},{"public_id":"co_052a433a24a9db59d8727f4d985f2bdd","status":"active","name":"chondrosenescence","description":"Age-dependent deterioration of chondrocyte function that 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