{"corpus_id":207339805,"paper_sha":"e86c867b2498b72121c11c414b1ed5591ff2fcc0","doi":"10.2217/fmb.14.127","arxiv_id":null,"pmid":25812460,"pmcid":null,"mag_id":2161781275,"dblp_id":null,"acl_id":null,"title":"A multifaceted 'omics' approach for addressing the challenge of antimicrobial resistance.","year":2015,"publication_date":"2015-03-27","venue":"Future Microbiology","journal":{"name":"Future microbiology","pages":"\n          365-76\n        ","volume":"10 3"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":69,"citation_count":27,"influential_citation_count":2,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Anti-Bacterial Agents","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D000900"},{"d":"Bacteria","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"},{"q":"isolation & purification","mj":false,"ui":"Q000302"}],"ui":"D001419"},{"d":"Bacterial Infections","mj":false,"qs":[{"q":"diagnosis","mj":true,"ui":"Q000175"},{"q":"drug therapy","mj":true,"ui":"Q000188"},{"q":"microbiology","mj":false,"ui":"Q000382"}],"ui":"D001424"},{"d":"Computational Biology","mj":false,"ui":"D019295"},{"d":"Diagnosis, Differential","mj":false,"ui":"D003937"},{"d":"Drug Resistance, Bacterial","mj":true,"ui":"D024881"},{"d":"Drug Utilization","mj":false,"ui":"D004363"},{"d":"Genomics","mj":true,"ui":"D023281"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Microbiota","mj":false,"ui":"D064307"},{"d":"Precision Medicine","mj":false,"qs":[{"q":"methods","mj":false,"ui":"Q000379"}],"ui":"D057285"},{"d":"Proteomics","mj":true,"ui":"D040901"},{"d":"Virus Diseases","mj":false,"qs":[{"q":"diagnosis","mj":false,"ui":"Q000175"}],"ui":"D014777"}],"chemicals":[{"n":"Anti-Bacterial Agents","ui":"D000900","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The inappropriate use of antibiotics has severe global health and economic consequences, including the emergence of antibiotic-resistant bacteria. A major driver of antibiotic misuse is the inability to accurately distinguish between bacterial and viral infections based on currently available diagnostic solutions. A multifaceted 'omics' approach that integrates personalized patient data such as genetic predisposition to infections (genomics), natural microbiota composition and immune response to infection (proteomics and transcriptomics) together with comprehensive pathogen profiling has the potential to help physicians improve their antimicrobial prescribing practices. 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