{"corpus_id":20754590,"paper_sha":"c445b8960a66d098bf1dbfeab1f6716ff5e3eba5","doi":"10.1016/j.anireprosci.2014.07.007","arxiv_id":null,"pmid":25069754,"pmcid":null,"mag_id":2030707483,"dblp_id":null,"acl_id":null,"title":"Seasonal variations cause morphological changes and altered spermatogenesis in the testes of viscacha (Lagostomus maximus).","year":2014,"publication_date":"2014-10-01","venue":"Animal Reproduction Science","journal":{"name":"Animal reproduction science","pages":"\n          316-24\n        ","volume":"149 3-4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":64,"citation_count":11,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Rodentia","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D012377"},{"d":"Seasons","mj":true,"ui":"D012621"},{"d":"Spermatogenesis","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D013091"},{"d":"Testis","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D013737"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://ri.conicet.gov.ar/bitstream/11336/79174/2/CONICET_Digital_Nro.9e5ba593-8f30-495b-aed3-130bac27ab44_A.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/c445b8960a66d098bf1dbfeab1f6716ff5e3eba5","s2_open_access_license":"CCBYNCSA","s2_open_access_status":"GREEN","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"This study complements the previous investigations of the reproductive biology of male viscachas, a rodent of a seasonal Hystricognathi that exhibits photoperiod-induced morphological variations in the reproductive system. In the present study, a quantitative analysis of spermatogenesis was performed during the summer and the spring. Spermatogonial cells were analyzed to determine by immunolabelling for STRA8 and DAZL, which are essential for spermatogenesis. Six free-living male viscachas were captured, three animals in the summer during the period of reproductive activity and three animals in the spring during the period of testicular regression. The testes of the viscachas were collected and processed for light microscopy, macroscopic and immunochemical analyses. The germ and Sertoli cells present in the seminiferous tubules were quantitatively analyzed in each animal. The efficiency coefficient for spermatogonial mitosis, meiotic yield, overall spermatogenesis yield and Sertoli cell index, revealed that the Sertoli cells in male viscachas captured during the summer had a reduced capacity to structurally and nutritionally support the developing round spermatids compared with the male viscachas captured during the spring. The animals produced less sperm during the spring than the summer, suggesting a seasonal impact on spermatogenesis. Immunolabelling for STRA8 and DAZL was detected during summer and spring seasons. These results suggest that in seasonal rodents, such as the male viscachas, the photoperiod promotes significant changes in the testis and in the germ cell yield.","claims":[{"public_id":"cl_9f7154666dd016f95f0b82ecc2461c52","status":"active","text":"Male viscachas produce less sperm during spring than during summer, indicating a seasonal effect on spermatogenesis.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_9f7154666dd016f95f0b82ecc2461c52"},{"public_id":"cl_b3c75d94f15d76858b43eca27904066a","status":"active","text":"STRA8 and DAZL immunolabelling is detected in both summer and spring testicular samples.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b3c75d94f15d76858b43eca27904066a"},{"public_id":"cl_ed210c808d963e879a6e73991708fd26","status":"active","text":"Seasonal differences produce significant morphological changes in the viscacha testis and alter germ cell yield.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_ed210c808d963e879a6e73991708fd26"},{"public_id":"cl_415f0a0d6a509e507a98cccd96385fb1","status":"active","text":"Sertoli cells in summer-captured male viscachas show reduced capacity to structurally and nutritionally support developing round spermatids compared with spring-captured animals.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_415f0a0d6a509e507a98cccd96385fb1"}],"concepts":[{"public_id":"co_18064251101c6f2496ed081d9b3fc1ed","status":"active","name":"seasonal differences","description":"Variation between summer and spring conditions associated with the animal's reproductive cycle.","types":["phenomenon"],"aliases":["seasonal variations"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_18064251101c6f2496ed081d9b3fc1ed"},{"public_id":"co_2ff281e59af9edb9d2d2aea203a4f0a9","status":"active","name":"STRA8","description":"A protein marker used to assess spermatogonial cells and their role in spermatogenesis.","types":["protein","marker"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2ff281e59af9edb9d2d2aea203a4f0a9"},{"public_id":"co_347798e45baaf5a2dcf28c6afb58e837","status":"active","name":"spring season","description":"The spring sampling period corresponding here to testicular regression.","types":["time period"],"aliases":["spring"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_347798e45baaf5a2dcf28c6afb58e837"},{"public_id":"co_54102efaa0297451221c198887670926","status":"active","name":"summer and spring seasons","description":"The two seasonal time points used for comparing reproductive activity and testicular regression.","types":["time period"],"aliases":["summer","spring"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_54102efaa0297451221c198887670926"},{"public_id":"co_9add522161829c612c62f118e559e001","status":"active","name":"spermatogenesis","description":"The process of sperm cell development in the seminiferous tubules.","types":["biological process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9add522161829c612c62f118e559e001"},{"public_id":"co_9e7e5deea563dc0d4590d52c66fca16b","status":"active","name":"DAZL","description":"A protein marker used to assess spermatogonial cells and their role in spermatogenesis.","types":["protein","marker"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9e7e5deea563dc0d4590d52c66fca16b"},{"public_id":"co_a0a768ded68955a900ef5f46f2d73c53","status":"active","name":"immunolabelling","description":"A staining technique used to detect specific proteins in tissue sections.","types":["method"],"aliases":["immunochemical analysis"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a0a768ded68955a900ef5f46f2d73c53"},{"public_id":"co_ad97589e7ff28c752b526309d0a64fbb","status":"active","name":"viscacha testis","description":"The testicular tissue of the male viscacha (Lagostomus maximus) examined for seasonal changes.","types":["anatomical structure"],"aliases":["testes of the viscacha","viscacha testes"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_ad97589e7ff28c752b526309d0a64fbb"},{"public_id":"co_c876a541036512cc7f13f74d3ee77980","status":"active","name":"Sertoli cells","description":"Supportive cells in the seminiferous tubules that aid germ cell development.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c876a541036512cc7f13f74d3ee77980"},{"public_id":"co_d7f65f9dc80af1b96d8f9ae67a60b123","status":"active","name":"summer season","description":"The summer sampling period corresponding here to reproductive activity.","types":["time period"],"aliases":["summer"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d7f65f9dc80af1b96d8f9ae67a60b123"},{"public_id":"co_ea35654041cc88b821cdfeef68df039b","status":"active","name":"round spermatids","description":"Post-meiotic haploid male germ cells that develop into sperm.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_ea35654041cc88b821cdfeef68df039b"},{"public_id":"co_f03e290d6fccbd2b96480b9b5959f1ea","status":"active","name":"germ cell yield","description":"The number or output of germ cells produced during spermatogenesis.","types":["measurement","outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f03e290d6fccbd2b96480b9b5959f1ea"}],"external_ids":{"DOI":"10.1016/j.anireprosci.2014.07.007","ArXiv":null,"PubMed":25069754,"PubMedCentral":null,"MAG":2030707483,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://ri.conicet.gov.ar/bitstream/11336/79174/2/CONICET_Digital_Nro.9e5ba593-8f30-495b-aed3-130bac27ab44_A.pdf","landing_url":"https://www.semanticscholar.org/paper/c445b8960a66d098bf1dbfeab1f6716ff5e3eba5","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBYNCSA","status":"GREEN","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":638183,"paper_uid":"f24a87e0-0701-418a-837b-f02638f33854","canonical_identity":{"paper_id":638183,"paper_uid":"f24a87e0-0701-418a-837b-f02638f33854","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/20754590"}