{"corpus_id":21350195,"paper_sha":"861a6d1d565c84a06b04d5cd6025acd472258726","doi":"10.1056/NEJMOA042002","arxiv_id":null,"pmid":15483279,"pmcid":null,"mag_id":2077523233,"dblp_id":null,"acl_id":null,"title":"A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms.","year":2004,"publication_date":"2004-10-14","venue":"New England Journal of Medicine","journal":{"name":"The New England journal of medicine","pages":"\n          1607-18\n        ","volume":"351 16"},"journal_issn":null,"journal_title":null,"publication_types":["Study","JournalArticle","ClinicalTrial"],"pubmed_pub_types":["Clinical Trial","Comparative Study","Journal Article","Multicenter Study","Randomized Controlled Trial","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine"],"reference_count":33,"citation_count":1993,"influential_citation_count":60,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Angioplasty","mj":true,"qs":[{"q":"mortality","mj":false,"ui":"Q000401"}],"ui":"D017130"},{"d":"Aortic Aneurysm, Abdominal","mj":false,"qs":[{"q":"mortality","mj":false,"ui":"Q000401"},{"q":"surgery","mj":true,"ui":"Q000601"}],"ui":"D017544"},{"d":"Blood Vessel Prosthesis","mj":false,"ui":"D001807"},{"d":"Elective Surgical Procedures","mj":false,"ui":"D017558"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Postoperative Complications","mj":false,"ui":"D011183"},{"d":"Treatment Outcome","mj":false,"ui":"D016896"},{"d":"Vascular Surgical Procedures","mj":false,"qs":[{"q":"methods","mj":true,"ui":"Q000379"},{"q":"mortality","mj":false,"ui":"Q000401"}],"ui":"D014656"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.jvascsurg.org/article/S0741521404014661/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/861a6d1d565c84a06b04d5cd6025acd472258726","s2_open_access_license":"publisher-specific-oa","s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"BACKGROUND: Although the initial results of endovascular repair of abdominal aortic aneurysms were promising, current evidence from controlled studies does not convincingly show a reduction in 30-day mortality relative to that achieved with open repair. METHODS: We conducted a multicenter, randomized trial comparing open repair with endovascular repair in 345 patients who had received a diagnosis of abdominal aortic aneurysm of at least 5 cm in diameter and who were considered suitable candidates for both techniques. The outcome events analyzed were operative (30-day) mortality and two composite end points of operative mortality and severe complications and operative mortality and moderate or severe complications. RESULTS: The operative mortality rate was 4.6 percent in the open-repair group (8 of 174 patients; 95 percent confidence interval, 2.0 to 8.9 percent) and 1.2 percent in the endovascular-repair group (2 of 171 patients; 95 percent confidence interval, 0.1 to 4.2 percent), resulting in a risk ratio of 3.9 (95 percent confidence interval, 0.9 to 32.9). The combined rate of operative mortality and severe complications was 9.8 percent in the open-repair group (17 of 174 patients; 95 percent confidence interval, 5.8 to 15.2 percent) and 4.7 percent in the endovascular-repair group (8 of 171 patients; 95 percent confidence interval, 2.0 to 9.0 percent), resulting in a risk ratio of 2.1 (95 percent confidence interval, 0.9 to 5.4). CONCLUSIONS: On the basis of the overall results of this trial, endovascular repair is preferable to open repair in patients who have an abdominal aortic aneurysm that is at least 5 cm in diameter. Long-term follow-up is needed to determine whether this advantage is sustained.","claims":[{"public_id":"cl_311853a193e43c8a56b7df7b4987a7e5","status":"active","text":"Endovascular repair is preferable to open repair for abdominal aortic aneurysms at least 5 cm in diameter on the basis of the overall trial results.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_311853a193e43c8a56b7df7b4987a7e5"},{"public_id":"cl_1162ddf3119ea515f0ea35149d13caac","status":"active","text":"Long-term follow-up is needed to determine whether the advantage of endovascular repair is sustained.","confidence":0.88,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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