{"corpus_id":216473397,"paper_sha":"8a709d84e96dc6f80cb271da5bcf6c35f9d5278f","doi":"10.22038/IJBMS.2020.40915.9695","arxiv_id":null,"pmid":32742604,"pmcid":"7375001","mag_id":3073638740,"dblp_id":null,"acl_id":null,"title":"Relationship between calcium circulation-related factors and muscle strength in rat sciatic nerve injury model","year":2020,"publication_date":"2020-05-01","venue":"Iranian Journal of Basic Medical Sciences","journal":{"name":"Iranian Journal of Basic Medical Sciences","pages":"654 - 662","volume":"23"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":42,"citation_count":4,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Objective(s): The purpose of this study is to investigate the indication function of the calcium circulation-related factors on the damage to muscle strength and contraction function after nerve injury. The target factors include ryanodine receptor (RyR), inositol-1,4,5-triphosphate receptor (IP3R), phospholamban (PLN), cryptocalcitonin (CASQ), ATPase and troponin C (TNNC). Materials and Methods: Sprague-Dawley (SD) rats were randomly divided into sham-operated group (SO), sciatic nerve injury group (SNI) and sciatic nerve disconnection group (SNT). Sciatic nerve function index and stretching test were used to examine the changes to muscle strength; bilateral gastrocnemius muscles were extracted after execution for gastrocnemius wet weight ratio test. HE staining slides and average cross-sectional area of muscle fibers were acquired to analyze the muscle atrophy. The transcription level of the factors was also measured. Results: Sciatic nerve damage in SNI group was significantly higher than that in SO group in the 6 weeks, but there was no significant difference between SNT and SO groups fallowing sciatic nerve damage. Sciatic nerve function in SNT group was worse than that in SNI group. The average cross-sectional area of gastrocnemius muscle fibers in SNI and SNT groups was significantly reduced compared to that in SO group. The transcriptional levels of RyR, PLN, CASQ, ATPase and TNNC in SNI and SNT groups were significantly different from those in SO group. Conclusion: Calcium circulation-related factors could be used as potential indicators for assessment of damages to muscle strength.","claims":[{"public_id":"cl_4b5ad5babcf86a5c425f85167787e598","status":"active","text":"Calcium circulation-related factors may serve as potential indicators for assessing damage to muscle strength after nerve injury.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_4b5ad5babcf86a5c425f85167787e598"},{"public_id":"cl_24f22e9a1bb19d4289c26cdff72f167e","status":"active","text":"Sciatic nerve injury and sciatic nerve disconnection both reduce gastrocnemius muscle fiber cross-sectional area compared with sham operation.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_24f22e9a1bb19d4289c26cdff72f167e"},{"public_id":"cl_6a39b8515221af359a9b36c69732a75b","status":"active","text":"Transcriptional levels of ryanodine receptor, phospholamban, cryptocalcitonin, ATPase, and troponin C differ significantly in injured and disconnected rats compared with sham-operated rats.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_6a39b8515221af359a9b36c69732a75b"}],"concepts":[{"public_id":"co_003bcb0a5df281d8eac7bf35acbc2c76","status":"active","name":"sciatic nerve injury model","description":"A rat experimental model in which the sciatic nerve is injured or disconnected to study downstream muscle effects.","types":["animal model"],"aliases":["sciatic nerve injury","sciatic nerve disconnection","SNI","SNT"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_003bcb0a5df281d8eac7bf35acbc2c76"},{"public_id":"co_03de96a9e515ad19f4c0ce16c84054c0","status":"active","name":"phospholamban","description":"A regulatory protein that modulates calcium uptake into the sarcoplasmic reticulum.","types":["protein"],"aliases":["PLN"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_03de96a9e515ad19f4c0ce16c84054c0"},{"public_id":"co_2053e12fdf2425d47d408dc49ca587a0","status":"active","name":"gastrocnemius muscle fiber cross-sectional area","description":"A histological measure of muscle fiber size used to assess muscle atrophy.","types":["measurement"],"aliases":["average cross-sectional area of muscle fibers"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2053e12fdf2425d47d408dc49ca587a0"},{"public_id":"co_649510d2f93dd22cf857573471ef0ed6","status":"active","name":"sham-operated group","description":"The control group that underwent surgery without the nerve injury procedure.","types":["control group"],"aliases":["SO"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_649510d2f93dd22cf857573471ef0ed6"},{"public_id":"co_984bd62dffc35a5836e6627c4a73d2af","status":"active","name":"muscle strength","description":"The force-producing capacity of muscle, evaluated here after nerve 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coupling.","types":["protein"],"aliases":["RyR"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a7926d867f93b8d9ee106dc366a4233a"},{"public_id":"co_af18c7d797c0d2dce2bd2786b86ea5e7","status":"active","name":"calcium circulation-related factors","description":"A set of molecules involved in intracellular calcium handling and muscle contraction regulation.","types":["biological factors"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_af18c7d797c0d2dce2bd2786b86ea5e7"},{"public_id":"co_d4b27dd4ce398435349c961033fc1842","status":"active","name":"nerve injury","description":"Damage to a nerve that can affect downstream muscle function and 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