{"corpus_id":21996093,"paper_sha":"5f2e4d0fb80c27495fc1c1882041cfe64cade7ac","doi":"10.1016/s0021-9258(19)40184-1","arxiv_id":null,"pmid":2104616,"pmcid":null,"mag_id":1508152421,"dblp_id":null,"acl_id":null,"title":"Signaling through phosphatidylcholine breakdown.","year":1990,"publication_date":"1990-01-05","venue":"Journal of Biological Chemistry","journal":{"name":"The Journal of biological chemistry","pages":"\n          1-4\n        ","volume":"265 1"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Review"],"s2_fields_of_study":["Biology","Medicine","Chemistry"],"reference_count":5,"citation_count":1160,"influential_citation_count":20,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Diglycerides","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D004075"},{"d":"GTP-Binding Proteins","mj":false,"qs":[{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D019204"},{"d":"Hydrolysis","mj":false,"ui":"D006868"},{"d":"Phosphatidic Acids","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D010712"},{"d":"Phosphatidylcholines","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D010713"},{"d":"Protein Kinase C","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D011493"},{"d":"Signal Transduction","mj":true,"ui":"D015398"}],"chemicals":[{"n":"Diglycerides","ui":"D004075","reg":"0"},{"n":"Phosphatidic Acids","ui":"D010712","reg":"0"},{"n":"Phosphatidylcholines","ui":"D010713","reg":"0"},{"n":"Protein Kinase C","ui":"D011493","reg":"EC 2.7.11.13"},{"n":"GTP-Binding Proteins","ui":"D019204","reg":"EC 3.6.1.-"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Several mechanisms of agonist control of PC hydrolysis have been described: control by G proteins, protein kinase C, Ca2+, and tyrosine kinases. The relative importance of these mechanisms remains to be demonstrated. Another major point is the physiological significance of PC hydrolysis. The prolonged formation of DAG from PC may be important in cellular control mechanisms that require long term activation of protein kinase C. The functions of PA are presently unknown, but the rapid formation of high concentrations of this lipid during stimulation by agonists strongly suggests that it has signaling functions. It is obvious that much work remains to define the physiological significance of agonist-stimulated PC breakdown.","claims":[{"public_id":"cl_3f00f1291b23ffd6d6db93061b05bc23","status":"active","text":"Agonist control of phosphatidylcholine hydrolysis involves G proteins, protein kinase C, Ca2+, and tyrosine kinases, but their relative importance remains unresolved.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_3f00f1291b23ffd6d6db93061b05bc23"},{"public_id":"cl_e4357b0d661010835933114e4d3aa505","status":"active","text":"Prolonged diacylglycerol formation from phosphatidylcholine may support cellular control mechanisms that require long-term activation of protein kinase C.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e4357b0d661010835933114e4d3aa505"},{"public_id":"cl_ca0c5f87b9a9603673bb76b15c014e29","status":"active","text":"Rapid accumulation of phosphatidic acid during agonist stimulation strongly suggests a signaling role for this lipid.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_ca0c5f87b9a9603673bb76b15c014e29"}],"concepts":[{"public_id":"co_0190e8fc7a7cc5cebbcbe01edcc176ff","status":"active","name":"tyrosine kinases","description":"Kinases that phosphorylate tyrosine residues in proteins and participate in signal transduction.","types":["enzyme","signaling protein"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0190e8fc7a7cc5cebbcbe01edcc176ff"},{"public_id":"co_1e654516f918b68d9bb47610c648c50e","status":"active","name":"phosphatidic acid","description":"A phospholipid intermediate that can also function in cellular signaling.","types":["lipid","signaling molecule"],"aliases":["PA"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1e654516f918b68d9bb47610c648c50e"},{"public_id":"co_370a6f5524b1a8ea4f04972d6696fc6b","status":"active","name":"agonist stimulation","description":"Activation of cellular receptors or pathways by an agonist ligand.","types":["experimental condition","cell signaling context"],"aliases":["agonist control","stimulation by agonists"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_370a6f5524b1a8ea4f04972d6696fc6b"},{"public_id":"co_7a8e34ae6075ec7bec3a6f56a1459bd6","status":"active","name":"G proteins","description":"GTP-binding regulatory proteins that mediate signal transduction from receptors.","types":["protein family"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_7a8e34ae6075ec7bec3a6f56a1459bd6"},{"public_id":"co_7e47a31bec88b4b493fdf57c79cac685","status":"active","name":"protein kinase C","description":"A serine/threonine protein kinase involved in intracellular signaling and regulated by lipid second messengers.","types":["enzyme","signaling protein"],"aliases":["PKC"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_7e47a31bec88b4b493fdf57c79cac685"},{"public_id":"co_98e6e8f4902a835b1ce32b1d06df2a6e","status":"active","name":"phosphatidylcholine hydrolysis","description":"Enzymatic breakdown of phosphatidylcholine into downstream lipid products.","types":["biochemical process"],"aliases":["PC hydrolysis","phosphatidylcholine breakdown","PC breakdown"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_98e6e8f4902a835b1ce32b1d06df2a6e"},{"public_id":"co_c506a4249b9c48956711ba279c0d9549","status":"active","name":"signaling functions","description":"Cellular roles in transmitting or modulating signals.","types":["biological role"],"aliases":["signal transduction roles"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c506a4249b9c48956711ba279c0d9549"},{"public_id":"co_c983d625ca019ea0fabe29cf331887bc","status":"active","name":"diacylglycerol","description":"A lipid second messenger generated by phospholipid metabolism.","types":["lipid","second messenger"],"aliases":["DAG"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c983d625ca019ea0fabe29cf331887bc"},{"public_id":"co_e91e64477f896af1088451a409251f97","status":"active","name":"Ca2+","description":"Calcium ions that act as intracellular regulators of many signaling pathways.","types":["ion","signaling molecule"],"aliases":["calcium"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e91e64477f896af1088451a409251f97"}],"external_ids":{"DOI":"10.1016/s0021-9258(19)40184-1","ArXiv":null,"PubMed":2104616,"PubMedCentral":null,"MAG":1508152421,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/21996093","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":632979,"paper_uid":"9c5bf275-7b66-40dd-9b76-5f5b5fea5bbb","canonical_identity":{"paper_id":632979,"paper_uid":"9c5bf275-7b66-40dd-9b76-5f5b5fea5bbb","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/21996093"}