{"corpus_id":22879484,"paper_sha":"019ab2c72eee8469e3218d3d2aca030864d5187d","doi":"10.1194/JLR.M500389-JLR200","arxiv_id":null,"pmid":16179738,"pmcid":null,"mag_id":1965570287,"dblp_id":null,"acl_id":null,"title":"Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis Published, JLR Papers in Press, September 22, 2005. DOI 10.1194/jlr.M500389-JLR200","year":2005,"publication_date":"2005-12-01","venue":"Journal of Lipid Research","journal":{"name":"Journal of Lipid Research","pages":"2752 - 2760","volume":"46"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, N.I.H., Extramural"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":72,"citation_count":28,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"1-Alkyl-2-acetylglycerophosphocholine Esterase","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D043203"},{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Cholesterol","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D002784"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Lipoproteins","mj":false,"qs":[{"q":"classification","mj":true,"ui":"Q000145"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008074"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Periodontitis","mj":false,"qs":[{"q":"enzymology","mj":false,"ui":"Q000201"},{"q":"metabolism","mj":true,"ui":"Q000378"},{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D010518"},{"d":"Triglycerides","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D014280"}],"chemicals":[{"n":"Lipoproteins","ui":"D008074","reg":"0"},{"n":"Triglycerides","ui":"D014280","reg":"0"},{"n":"Cholesterol","ui":"D002784","reg":"97C5T2UQ7J"},{"n":"1-Alkyl-2-acetylglycerophosphocholine Esterase","ui":"D043203","reg":"EC 3.1.1.47"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.jlr.org/article/S0022227520328649/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/019ab2c72eee8469e3218d3d2aca030864d5187d","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"In this study, we examined whether the documented increase of plasma triglycerides in patients with generalized aggressive periodontitis (GAgP) is associated with changes in lipoprotein subclass distribution and/or LDL-associated platelet-activating factor acetylhydrolase (PAF-AH) activity. Lipoprotein subclasses were analyzed in whole plasma samples using nuclear magnetic resonance methods. Compared with subjects without periodontitis (NP subjects; n = 12), GAgP subjects (n = 12) had higher plasma levels of large, medium, and small VLDL (35.0 ± 6.7 vs. 63.1 ± 9.6 nmol/l; P = 0.025), higher levels of intermediate density lipoprotein (24.8 ± 11.6 vs. 87.2 ± 16.6 nmol/l; P = 0.006), lower levels of large LDL (448.3 ± 48.5 vs. 315.8 ± 59.4 nmol/l; P = 0.098), and higher levels of small LDL (488.2 ± 104.2 vs. 946.7 ± 151.6 nmol/l; P = 0.021). The average size of LDL from NP and GAgP subjects was 21.4 ± 0.2 and 20.6 ± 0.3 nm, respectively (P = 0.031). Compared with NP subjects, GAgP subjects had a greater number of circulating LDL particles (961.3 ± 105.3 vs. 1,349.0 ± 133.2 nmol/l; P = 0.032). Differences in the plasma levels of large, medium, and small HDL were not statistically significant. NP and GAgP subjects had similar plasma levels of total LDL-associated PAF-AH activity; however, LDL of GAgP subjects contained less PAF-AH activity per microgram of LDL protein (1,458.0 ± 171.0 and 865.2 ± 134 pmol/min/μg; P = 0.014). These results indicate that, in general, GAgP subjects have a more atherogenic lipoprotein profile and lower LDL-associated PAF-AH activity than NP subjects. These differences may help explain the increased risk of GAgP subjects for cardiovascular disease.","claims":[{"public_id":"cl_ee2df6613a418f25ca6b50aff2e0349a","status":"active","text":"Generalized aggressive periodontitis is associated with a more atherogenic lipoprotein profile and lower LDL-associated PAF-AH activity than periodontitis-free controls.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_ee2df6613a418f25ca6b50aff2e0349a"},{"public_id":"cl_8515cce55083ea29217f5745e34a6261","status":"active","text":"Generalized aggressive periodontitis is associated with higher plasma levels of large, medium, and small VLDL and of intermediate density lipoprotein, along with higher small LDL and lower large LDL.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8515cce55083ea29217f5745e34a6261"},{"public_id":"cl_74c931b70d1470204b809dae1313b67f","status":"active","text":"Plasma levels of large, medium, and small HDL do not differ significantly between subjects with generalized aggressive periodontitis and subjects without periodontitis.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_74c931b70d1470204b809dae1313b67f"},{"public_id":"cl_abf559e2b9ad73ceb35b55ee40028995","status":"active","text":"Subjects with generalized aggressive periodontitis have smaller LDL particle size and a greater number of circulating LDL particles than subjects without periodontitis.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_abf559e2b9ad73ceb35b55ee40028995"},{"public_id":"cl_6bb8b2ced95caab36c5ebf113b1e7cbb","status":"active","text":"Total LDL-associated platelet-activating factor acetylhydrolase activity is similar between groups, but LDL from generalized aggressive periodontitis subjects has less PAF-AH activity per microgram of LDL protein.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_6bb8b2ced95caab36c5ebf113b1e7cbb"}],"concepts":[{"public_id":"co_0b263de9cdedbbe63a1b8411854b9c2b","status":"active","name":"generalized aggressive periodontitis","description":"A severe form of periodontitis characterized by rapid attachment and bone loss affecting multiple teeth.","types":["condition"],"aliases":["GAgP"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0b263de9cdedbbe63a1b8411854b9c2b"},{"public_id":"co_180c1850cf4e3325aeaa2609c0c3b11b","status":"active","name":"high-density lipoprotein","description":"A plasma lipoprotein class that was assessed in large, medium, and small subclasses.","types":["lipoprotein class"],"aliases":["HDL"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_180c1850cf4e3325aeaa2609c0c3b11b"},{"public_id":"co_195dd3b8ba0334e5fe296b100577055f","status":"active","name":"low-density lipoprotein","description":"A cholesterol-carrying lipoprotein class in plasma, analyzed here by particle size and particle number.","types":["lipoprotein class"],"aliases":["LDL"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_195dd3b8ba0334e5fe296b100577055f"},{"public_id":"co_840386528d806e54b34803f8011e9c49","status":"active","name":"lipoprotein subclass distribution","description":"The relative concentrations of different lipoprotein particle subclasses in plasma.","types":["measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_840386528d806e54b34803f8011e9c49"},{"public_id":"co_842ecf09b3c64a799bc46142153b0d5a","status":"active","name":"atherogenic lipoprotein profile","description":"A lipoprotein pattern characterized by features associated with increased atherogenic risk.","types":["profile"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_842ecf09b3c64a799bc46142153b0d5a"},{"public_id":"co_8bfa3f1f25ddc0b01634b693dd773b1f","status":"active","name":"circulating LDL particles","description":"The number of LDL particles present in the bloodstream.","types":["measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8bfa3f1f25ddc0b01634b693dd773b1f"},{"public_id":"co_a13ed68781edafb251bdc653ec1c5c8a","status":"active","name":"intermediate density lipoprotein","description":"A lipoprotein fraction that lies between VLDL and LDL in density.","types":["lipoprotein class"],"aliases":["IDL"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a13ed68781edafb251bdc653ec1c5c8a"},{"public_id":"co_d2bc50638f7d376aa2da32ee07e43b1b","status":"active","name":"very low-density lipoprotein","description":"A triglyceride-rich lipoprotein class present in plasma, subdivided into large, medium, and small particles.","types":["lipoprotein class"],"aliases":["VLDL"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d2bc50638f7d376aa2da32ee07e43b1b"},{"public_id":"co_f48788f45e9d3393e2d3a2a65a78d432","status":"active","name":"platelet-activating factor acetylhydrolase","description":"An enzyme associated with LDL that hydrolyzes platelet-activating factor and related lipids.","types":["enzyme"],"aliases":["PAF-AH"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f48788f45e9d3393e2d3a2a65a78d432"},{"public_id":"co_f8b1c64e35e83796570e204185b6cca7","status":"active","name":"subjects without periodontitis","description":"The control group of participants who did not have periodontitis.","types":["control group"],"aliases":["NP subjects","periodontitis-free controls"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f8b1c64e35e83796570e204185b6cca7"}],"external_ids":{"DOI":"10.1194/JLR.M500389-JLR200","ArXiv":null,"PubMed":16179738,"PubMedCentral":null,"MAG":1965570287,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"http://www.jlr.org/article/S0022227520328649/pdf","landing_url":"https://www.semanticscholar.org/paper/019ab2c72eee8469e3218d3d2aca030864d5187d","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"HYBRID","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":638993,"paper_uid":"5212f140-efa0-40d1-a112-95c55a9c1c04","canonical_identity":{"paper_id":638993,"paper_uid":"5212f140-efa0-40d1-a112-95c55a9c1c04","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/22879484"}