{"corpus_id":231931568,"paper_sha":"d430345a0a315646225ca64bd37143d78044ffb6","doi":"10.1186/s12872-021-01907-9","arxiv_id":null,"pmid":33593303,"pmcid":"7885551","mag_id":null,"dblp_id":null,"acl_id":null,"title":"The effects of submaximal exercise and cold exposure on blood coagulation parameters in coronary artery disease patients","year":2021,"publication_date":"2021-02-16","venue":"BMC Cardiovascular Disorders","journal":{"name":"BMC Cardiovascular Disorders","pages":null,"volume":"21"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Environmental Science"],"reference_count":52,"citation_count":6,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Biomarkers","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D015415"},{"d":"Blood Coagulation","mj":true,"ui":"D001777"},{"d":"Cold Temperature","mj":true,"ui":"D003080"},{"d":"Coronary Artery Disease","mj":false,"qs":[{"q":"blood","mj":true,"ui":"Q000097"},{"q":"diagnosis","mj":false,"ui":"Q000175"}],"ui":"D003324"},{"d":"Exercise","mj":true,"ui":"D015444"},{"d":"Factor VII","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005167"},{"d":"Fibrin Fibrinogen Degradation Products","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005338"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Random Allocation","mj":false,"ui":"D011897"},{"d":"Time Factors","mj":false,"ui":"D013997"},{"d":"von Willebrand Factor","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D014841"}],"chemicals":[{"n":"Biomarkers","ui":"D015415","reg":"0"},{"n":"Fibrin Fibrinogen Degradation Products","ui":"D005338","reg":"0"},{"n":"fibrin fragment D","ui":"C036309","reg":"0"},{"n":"von Willebrand Factor","ui":"D014841","reg":"0"},{"n":"Factor VII","ui":"D005167","reg":"9001-25-6"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://bmccardiovascdisord.biomedcentral.com/track/pdf/10.1186/s12872-021-01907-9","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/d430345a0a315646225ca64bd37143d78044ffb6","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Background Both exercise and cold exposure increase blood coagulation potential but their combined effects are not known. The purpose of the present study was to assess blood coagulation factors in response to submaximal exercise in the cold environment among patients with stable coronary artery disease (CAD). Methods Sixteen men (61.1 ± 7.1 years) with stable CAD participated in three 30-min experimental conditions (seated rest in − 15 °C and exercise in both + 22 °C and − 15 °C) in random order. The employed exercise consisted of brisk walking (66–69% of maximal heart rate). Factor VII (FVII), fibrinogen, D-dimer and von Willebrand factor (vWF) were analyzed from blood samples obtained before, immediately and one hour after each experiment. Results On average, FVII activity (95% confidence interval, CI) was 123 (108–143) %, 123 (106–140) %, 121 (103–139) % (baseline, recovery 1, recovery 2), fibrinogen concentration (95% CI) 3.81 (3.49–4.12) g/l, 3.71 (3.34–4.08) g/l, 3.65 (3.26–4.05) g/l, D-dimer concentration (95% CI) 0.42 (0.28–0.56) µg/ml, 0.42 (0.29-.55) µg/ml and 0.39 (0.29–0.49) µg/ml, and vWF activity (95% CI) 184 (135–232) %, 170 (128–212) % and 173 (129–217) % after exercise in the cold. Average FVII activity varied from 122 to 123%, fibrinogen concentration from 3.71 to 3.75 g/l, D-dimer concentration from 0.35 to 0.51 µg/ml and von Willebrand factor activity from 168 to 175% immediately after each three experimental condition. Conclusions Our findings suggest that submaximal lower body exercise carried out in a cold environment does not significantly affect blood coagulation parameters among patients with stable CAD.","claims":[{"public_id":"cl_e5e40677aacceed42d1c547fe715cec8","status":"active","text":"Blood coagulation measurements remained broadly similar across seated rest in −15 °C, brisk walking in +22 °C, and brisk walking in −15 °C.","confidence":0.84,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e5e40677aacceed42d1c547fe715cec8"},{"public_id":"cl_e85f9af34455dcd702f45f6856929458","status":"active","text":"Factor VII activity, fibrinogen concentration, D-dimer concentration, and von Willebrand factor activity showed only small changes after exercise in the cold.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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