{"corpus_id":23287854,"paper_sha":"9c946ea9cc23c6382b76e2752a028c24d03addd8","doi":"10.1097/00005176-198201020-00010","arxiv_id":null,"pmid":6764506,"pmcid":null,"mag_id":2335302859,"dblp_id":null,"acl_id":null,"title":"Continuous Insulin Infusion in Hyperglycemic, Very Low Birth Weight Infants","year":1982,"publication_date":"1982-06-01","venue":"Journal of Pediatric Gastroenterology and Nutrition - JPGN","journal":{"name":"Journal of Pediatric Gastroenterology and Nutrition","pages":"211–218","volume":"1"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Medicine"],"reference_count":0,"citation_count":60,"influential_citation_count":2,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Blood Glucose","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D001786"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Hyperglycemia","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"drug therapy","mj":true,"ui":"Q000188"}],"ui":"D006943"},{"d":"Infant Nutritional Physiological Phenomena","mj":false,"ui":"D007227"},{"d":"Infant, Low Birth Weight","mj":true,"ui":"D007230"},{"d":"Infant, Newborn","mj":false,"ui":"D007231"},{"d":"Infant, Premature, Diseases","mj":false,"qs":[{"q":"drug therapy","mj":true,"ui":"Q000188"}],"ui":"D007235"},{"d":"Infusions, Parenteral","mj":false,"qs":[{"q":"adverse effects","mj":false,"ui":"Q000009"}],"ui":"D007263"},{"d":"Insulin","mj":false,"qs":[{"q":"administration & dosage","mj":true,"ui":"Q000008"},{"q":"adverse effects","mj":false,"ui":"Q000009"},{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D007328"}],"chemicals":[{"n":"Blood Glucose","ui":"D001786","reg":"0"},{"n":"Insulin","ui":"D007328","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Continuous insulin infusion (CII) was used to increase intravenous glucose tolerance in 10 extremely premature (26.2 +/- 0.04 weeks, means +/- SEM) very low birth weight (819 +/- 53 g) hyperglycemic infants. CII was continued for 3-36 days. Over the first 72 h of insulin administration the mean amount of glucose tolerated rose from 0.35 +/- 0.06 to 0.67 +/- 0.06 g/kg/h and caloric intake derived from intravenous glucose increased from 29 to 56 kcal/kg/day. Insulin doses required to maintain normoglycemia ranged from 0.005-0.052 U/kg/h initially to 0.002-0.086 U/kg/h after 72 h of CII. Plasma insulin levels were significantly higher during insulin infusion. The low insulin doses required to maintain normoglycemia were consistent with a state of relative insulin deficiency, rather than insulin resistance. Mean plasma insulin/glucose ratios were significantly higher in normoglycemic versus hyperglycemic infants (0.40 +/- 0.08 vs. 0.14 +/- 0.05). Less than 1% of all blood glucose estimations were less than 25 mg/dl. Seventy-eight percent were within the normal range (greater than 45, less than 130 mg/dl). The rate of weight gain increased during CII in 8 of the 10 infants. CII may be useful in extremely premature, very-low-birth-weight infants in whom glucose intolerance persists despite conservative treatment, and either severely limits caloric intake, or results in life-threatening hyperglycemia.","claims":[{"public_id":"cl_75a60bc6f4240b0a00863737b44708bd","status":"active","text":"Continuous insulin infusion increased intravenous glucose tolerance in extremely premature very low birth weight infants, raising tolerated glucose delivery over the first 72 hours.","confidence":0.98,"contributors":[{"id":391,"public_id":"x53qfq3ny9","public_label":"kafkapple (x53qfq3ny9)","roles":["extraction"],"url":"https://sah.borca.ai/u/x53qfq3ny9"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale 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normoglycemia required low insulin doses, and plasma insulin levels were significantly higher during insulin infusion.","confidence":0.95,"contributors":[{"id":391,"public_id":"x53qfq3ny9","public_label":"kafkapple (x53qfq3ny9)","roles":["extraction"],"url":"https://sah.borca.ai/u/x53qfq3ny9"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_c4b3051d8ba1f316fe744ec3cf9293d4"},{"public_id":"cl_b70d1dd9911b88c8c1f0a1e6a41366f8","status":"active","text":"Plasma insulin/glucose ratios were significantly higher in normoglycemic infants than in hyperglycemic infants.","confidence":0.97,"contributors":[{"id":391,"public_id":"x53qfq3ny9","public_label":"kafkapple 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