{"corpus_id":23604214,"paper_sha":"bf4d3621769e2baa97e46b4107b2266acc7134da","doi":"10.4049/jimmunol.129.2.694","arxiv_id":null,"pmid":6979580,"pmcid":null,"mag_id":1576426340,"dblp_id":null,"acl_id":null,"title":"Role of syngeneic Ia+ accessory cells in the generation of allospecific CTL responses.","year":1982,"publication_date":"1982-08-01","venue":"Journal of Immunology","journal":{"name":"Journal of immunology","pages":"\n          694-7\n        ","volume":"129 2"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Biology","Medicine"],"reference_count":0,"citation_count":39,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Antibodies, Monoclonal","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D000911"},{"d":"Binding, Competitive","mj":false,"ui":"D001667"},{"d":"Cell Adhesion","mj":false,"ui":"D002448"},{"d":"Cytotoxicity, Immunologic","mj":true,"ui":"D003602"},{"d":"Histocompatibility Antigens Class II","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D000949"},{"d":"Isoantigens","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D007519"},{"d":"Lymphocyte Cooperation","mj":true,"ui":"D008211"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Mice, Inbred AKR","mj":false,"ui":"D008806"},{"d":"Mice, Inbred BALB C","mj":false,"ui":"D008807"},{"d":"Mice, Inbred C3H","mj":false,"ui":"D008809"},{"d":"Mice, Inbred C57BL","mj":false,"ui":"D008810"},{"d":"Spleen","mj":false,"qs":[{"q":"cytology","mj":true,"ui":"Q000166"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D013154"},{"d":"T-Lymphocytes","mj":false,"qs":[{"q":"classification","mj":false,"ui":"Q000145"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D013601"}],"chemicals":[{"n":"Antibodies, Monoclonal","ui":"D000911","reg":"0"},{"n":"Histocompatibility Antigens Class II","ui":"D000949","reg":"0"},{"n":"Isoantigens","ui":"D007519","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Under conditions in which antigen dose is suboptimal, the recognition of Ia determinants is a necessary component of the generation of allospecific CTL responses. With monoclonal anti-Ia antibodies used as blocking reagents, it is demonstrated that the recognition of alloantigens may proceed via two pathways. Alloantigens can be recognized in the context of syngeneic Ia determinants in a similar fashion to conventional antigens. If, however, the Ia+ cells are removed from the responder population, the generation of such responses involves the recognition of allogeneic Ia determinants directly. 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