{"corpus_id":245453816,"paper_sha":"dcbe57c3684f9d3c7261ec43326b0c463aa1e438","doi":"10.1111/cpr.13167","arxiv_id":null,"pmid":34939255,"pmcid":"8780926","mag_id":null,"dblp_id":null,"acl_id":null,"title":"Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis","year":2021,"publication_date":"2021-12-22","venue":"Cell Proliferation","journal":{"name":"Cell Proliferation","pages":null,"volume":"55"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":113,"citation_count":78,"influential_citation_count":7,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Cell Death","mj":false,"ui":"D016923"},{"d":"Cell Survival","mj":false,"ui":"D002470"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Membrane Microdomains","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D021962"},{"d":"Neoplasm Metastasis","mj":false,"ui":"D009362"},{"d":"Neoplasms","mj":false,"qs":[{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D009369"},{"d":"Signal Transduction","mj":true,"ui":"D015398"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Lipid rafts are cholesterol‐ and sphingolipid‐enriched specialized membrane domains within the plasma membrane. Lipid rafts regulate the density and activity of signal receptors by compartmentalizing them, promoting signalling cascades that play important roles in the survival, death and metastasis of cancer cells. In this review, we emphasize the current concept initially postulated by F. Mollinedo and C. Gajate on the importance of lipid rafts in cancer survival, death and metastasis by describing representative signalling pathways, including the IGF system and the PI3K/AKT, Fas/CD95, VEGF/VEGFR2 and CD44 signalling pathways, and we also discuss the concept of CASMER (cluster of apoptotic signalling molecule‐enriched rafts), coined, originally introduced and further advanced by F. Mollinedo and C. Gajate in the period 2005–2010. Then, we summarize relevant research progress and suggest that lipid rafts play important roles in the survival, death and metastasis of cancer cells, making them promising targets for cancer therapy.","claims":[{"public_id":"cl_564e0fd209a7c26ddb1bf27f951992d3","status":"active","text":"CASMER is a named concept for clusters of apoptotic signaling molecule-enriched rafts that is discussed as part of the lipid raft framework in cancer.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_564e0fd209a7c26ddb1bf27f951992d3"},{"public_id":"cl_e5687b4e432a53a7f74053abf2067af0","status":"active","text":"Lipid rafts are important for cancer cell survival, death, and metastasis by regulating receptor density and activity through membrane compartmentalization.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e5687b4e432a53a7f74053abf2067af0"},{"public_id":"cl_015450971ffb4ce46fd1a212286eeeb4","status":"active","text":"Lipid rafts are presented as promising targets for cancer therapy.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_015450971ffb4ce46fd1a212286eeeb4"},{"public_id":"cl_61cc66cedc168339e742935f57a455af","status":"active","text":"Representative signaling pathways discussed in relation to lipid rafts include the IGF system, PI3K/AKT, Fas/CD95, VEGF/VEGFR2, and CD44 signaling pathways.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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