{"corpus_id":245943304,"paper_sha":"58a09cf2764857e8a5c6efeea39206fe7737af4f","doi":"10.1016/j.mrgentox.2022.503441","arxiv_id":null,"pmid":35151427,"pmcid":null,"mag_id":null,"dblp_id":null,"acl_id":null,"title":"Septilin: A versatile anticlastogenic, antigenotoxic, antioxidant and histoprotective herbo-mineral formulation on cisplatin-induced toxicity in mice.","year":2022,"publication_date":"2022-01-01","venue":"Mutation Research. Genetic Toxicology and Environmental Mutagenesis","journal":{"name":"Mutation research. Genetic toxicology and environmental mutagenesis","pages":"\n          503441\n        ","volume":"874-875"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":91,"citation_count":5,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Antioxidants","mj":true,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D000975"},{"d":"Cisplatin","mj":true,"qs":[{"q":"toxicity","mj":false,"ui":"Q000633"}],"ui":"D002945"},{"d":"DNA","mj":false,"ui":"D004247"},{"d":"Glutathione","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005978"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Minerals","mj":false,"ui":"D008903"},{"d":"Oxidative Stress","mj":false,"ui":"D018384"},{"d":"Plant Extracts","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"},{"q":"urine","mj":true,"ui":"Q000652"}],"ui":"D010936"},{"d":"Superoxide Dismutase","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D013482"}],"chemicals":[{"n":"Antioxidants","ui":"D000975","reg":"0"},{"n":"Minerals","ui":"D008903","reg":"0"},{"n":"Plant Extracts","ui":"D010936","reg":"0"},{"n":"septilin","ui":"C047352","reg":"0"},{"n":"DNA","ui":"D004247","reg":"9007-49-2"},{"n":"Superoxide Dismutase","ui":"D013482","reg":"EC 1.15.1.1"},{"n":"Glutathione","ui":"D005978","reg":"GAN16C9B8O"},{"n":"Cisplatin","ui":"D002945","reg":"Q20Q21Q62J"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Septilin (Spt), a herbo-mineral formulation contains the extracts of Maharasanadi qoath, Tinospora cordifolia, Rubia cordifolia, Emblica officinalis, Moringa pterigosperma, Glycyrrhiza glabra and powders of Balsamodendron mukul and Shankha bhasma. In the present study, the anticlastogenic, antigenotoxic, antioxidant and histoprotective effects of Spt against cisplatin (Csp) induced toxicity in Swiss albino mice were investigated. The micronucleus (MN) test was used to assess the anticlastogenic potential of Spt (125, 250 and 500 mg/kg bw; p.o., 5 days) on somatic cells of mice. The sperm shape abnormality assay detects germinal nuclear damage, which induces spermatogenic dysfunction. Comet assay was employed to study the antigenotoxic potential of Spt on Csp (10 mg/kg bw; i.p.) induced DNA strand breaks in bone marrow cells of mice. The antioxidant enzyme activity of liver superoxide dismutase (SOD) and a biological antioxidant, reduced glutathione (GSH) were measured to determine its hepatoprotective property. The ability of Spt to protect against the histopathologic alterations accompanying Csp-induced liver and testicular injury was studied. The frequencies of MN induced by Csp in bone marrow and peripheral blood cells of mice were significantly decreased by the pre-treatment of Spt. Csp treatment increased the percentage of DNA strand breaks and depleted levels of SOD and GSH content along with histopathological changes. Supplementation of Spt attenuated the toxicity of Csp in liver and testes tissues possible viaimprovement of enzymatic and histological parameters toward normal. This study suggests that the protection offered by Spt against Csp-induced toxicity is partly related to the maintenance of the antioxidant system. Overall, this study shows the protective role of Spt against Csp-induced toxicity in somatic and male germinal cells of mice.","claims":[{"public_id":"cl_6b04b551f43e44cb17a56617cf9adbc3","status":"active","text":"Pre-treatment with Septilin significantly decreased cisplatin-induced micronuclei frequencies in bone marrow and peripheral blood cells of mice.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_6b04b551f43e44cb17a56617cf9adbc3"},{"public_id":"cl_a264feb1f6f3777c325b5460f585f679","status":"active","text":"Protection against cisplatin-induced toxicity is partly related to maintenance of the antioxidant system.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a264feb1f6f3777c325b5460f585f679"},{"public_id":"cl_7d1e0b2269e8ba7b4c86911d21c8891f","status":"active","text":"Septilin attenuated cisplatin-induced DNA strand breaks in bone marrow cells as measured by comet assay.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_7d1e0b2269e8ba7b4c86911d21c8891f"},{"public_id":"cl_3290c6b33f2eb5349d9993dbdf9530b7","status":"active","text":"Septilin improved antioxidant and histological parameters toward normal in liver and testes after cisplatin exposure, including superoxide dismutase, reduced glutathione, and tissue pathology.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_3290c6b33f2eb5349d9993dbdf9530b7"}],"concepts":[{"public_id":"co_220420ad63cd1ab896a4ea9e80b47386","status":"active","name":"micronucleus test","description":"A cytogenetic assay used to assess chromosomal damage by counting micronuclei in cells.","types":["assay"],"aliases":["MN test"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_220420ad63cd1ab896a4ea9e80b47386"},{"public_id":"co_2d18a59919843d170406d0a417e960cb","status":"active","name":"antioxidant system","description":"The cellular defense network that limits oxidative damage through antioxidant enzymes and molecules.","types":["biological system"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2d18a59919843d170406d0a417e960cb"},{"public_id":"co_4243117919d33fa6fdafc1589692a58b","status":"active","name":"liver and testicular injury","description":"Damage to liver and testis tissues assessed after cisplatin treatment.","types":["organ injury"],"aliases":["liver and testes tissues"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4243117919d33fa6fdafc1589692a58b"},{"public_id":"co_42b76957e28ff4da426ad43c90bd3503","status":"active","name":"Septilin","description":"A herbo-mineral formulation composed of several plant extracts and mineral powders.","types":["herbo-mineral formulation"],"aliases":["Spt"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_42b76957e28ff4da426ad43c90bd3503"},{"public_id":"co_432a40f3b6ff64c5d3993ecd4504b77a","status":"active","name":"cisplatin-induced toxicity","description":"Adverse cellular and tissue damage caused by cisplatin treatment in mice.","types":["toxicity"],"aliases":["Csp-induced toxicity"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_432a40f3b6ff64c5d3993ecd4504b77a"},{"public_id":"co_5f00ab8d18cb08fcb56aedac322aee15","status":"active","name":"superoxide dismutase","description":"An antioxidant enzyme measured in liver tissue as a marker of oxidative status.","types":["enzyme"],"aliases":["SOD"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5f00ab8d18cb08fcb56aedac322aee15"},{"public_id":"co_65982ccd7bbff03fe87a1e3dbdfdc645","status":"active","name":"bone marrow cells","description":"Hematopoietic cells from mouse bone marrow used for genotoxicity assessment.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_65982ccd7bbff03fe87a1e3dbdfdc645"},{"public_id":"co_7497d45e51b30a1b6548196003b5c549","status":"active","name":"histopathological changes","description":"Microscopic tissue alterations used to evaluate liver and testicular injury.","types":["pathology"],"aliases":["histological alterations"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_7497d45e51b30a1b6548196003b5c549"},{"public_id":"co_c729e0694ff5f95d4b33d512c7e50884","status":"active","name":"peripheral blood cells","description":"Circulating blood cells used to evaluate micronuclei formation in mice.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c729e0694ff5f95d4b33d512c7e50884"},{"public_id":"co_dad60654e75f3a34725f834797f5289d","status":"active","name":"reduced glutathione","description":"A biological antioxidant measured in liver tissue as part of the oxidative defense system.","types":["antioxidant"],"aliases":["GSH"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_dad60654e75f3a34725f834797f5289d"},{"public_id":"co_e740b7ba892e318524b0fbe27c7a310e","status":"active","name":"comet assay","description":"A DNA damage assay used to detect DNA strand breaks in individual cells.","types":["assay"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e740b7ba892e318524b0fbe27c7a310e"}],"external_ids":{"DOI":"10.1016/j.mrgentox.2022.503441","ArXiv":null,"PubMed":35151427,"PubMedCentral":null,"MAG":null,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/245943304","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":637962,"paper_uid":"8d586ef0-7d51-44bc-97bc-0a59ccf9b20d","canonical_identity":{"paper_id":637962,"paper_uid":"8d586ef0-7d51-44bc-97bc-0a59ccf9b20d","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/245943304"}