{"corpus_id":24655102,"paper_sha":"af4e75b8cb7a39251f06e2e0c23cc64f2e84521f","doi":"10.1021/acsmacrolett.7b00603","arxiv_id":null,"pmid":28966880,"pmcid":"5617330","mag_id":2751761487,"dblp_id":null,"acl_id":null,"title":"Two-Dimensional Controlled Syntheses of Polypeptide Molecular Brushes via N-Carboxyanhydride Ring-Opening Polymerization and Ring-Opening Metathesis Polymerization","year":2017,"publication_date":"2017-09-08","venue":"ACS Macro Letters","journal":{"name":"ACS Macro Letters","pages":"1031 - 1035","volume":"6"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Materials Science","Chemistry"],"reference_count":45,"citation_count":38,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsmacrolett.7b00603","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/af4e75b8cb7a39251f06e2e0c23cc64f2e84521f","s2_open_access_license":"publisher-specific-oa","s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Well-defined molecular brushes bearing polypeptides as side chains were prepared by a “grafting through” synthetic strategy with two-dimensional control over the brush molecular architectures. By integrating N-carboxyanhydride ring-opening polymerizations (NCA ROPs) and ring-opening metathesis polymerizations (ROMPs), desirable segment lengths of polypeptide side chains and polynorbornene brush backbones were independently constructed in controlled manners. The N2 flow accelerated NCA ROP was utilized to prepare polypeptide macromonomers with different lengths initiated from a norbornene-based primary amine, and those macromonomers were then polymerized via ROMP. It was found that a mixture of dichloromethane and an ionic liquid were required as the solvent system to allow for construction of molecular brush polymers having densely-grafted peptide chains emanating from a polynorbornene backbone, poly(norbornene-graft-poly(β-benzyl-l-aspartate)) (P(NB-g-PBLA)). Highly efficient postpolymerization modification was achieved by aminolysis of PBLA side chains for facile installment of functional moieties onto the molecular brushes.","claims":[{"public_id":"cl_8fa71f5d1ae08ca896677df2a8ea2a87","status":"active","text":"A mixture of dichloromethane and an ionic liquid was required to construct densely grafted poly(norbornene-graft-poly(β-benzyl-l-aspartate)) molecular brushes.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8fa71f5d1ae08ca896677df2a8ea2a87"},{"public_id":"cl_ff9fc7822c6b142235e162c9a177f50d","status":"active","text":"N-carboxyanhydride ring-opening polymerization and ring-opening metathesis polymerization enabled independent control of polypeptide side-chain length and polynorbornene backbone 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