{"corpus_id":255475136,"paper_sha":"9e85589a4560ac75373e1bd9e8d045159f8a4e2b","doi":"10.1016/j.jacc.2022.09.051","arxiv_id":null,"pmid":36599755,"pmcid":null,"mag_id":null,"dblp_id":null,"acl_id":null,"title":"Takayasu Arteritis: JACC Focus Seminar 3/4.","year":2022,"publication_date":"2022-12-13","venue":"Journal of the American College of Cardiology","journal":{"name":"Journal of the American College of Cardiology","pages":null,"volume":null},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Medicine"],"reference_count":45,"citation_count":43,"influential_citation_count":5,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Takayasu arteritis is a rare idiopathic large-vessel vasculitis that typically affects young women. An early \"prepulseless\" stage is often missed, associated with nonspecific constitutional symptoms (fever, malaise, and weight loss) and elevated inflammatory markers. Unchecked disease progression leads to the \"pulseless\" stage, manifest clinically by missing pulses, vascular tenderness, and ischemic symptoms (limb claudication, dizziness, angina, and renovascular hypertension), and is characterized pathologically by arterial wall thickening and stenotic/occlusive lesions or aneurysm formation. Vascular complications (stroke, blindness, heart failure, and aneurysm rupture) could follow unless disease progression is halted by immunosuppressive therapy and critical lesions are palliated by timely endovascular therapy or open surgery. Early diagnosis, effective therapy, and lifelong surveillance for disease activity relapses and vascular disease progression are critical to successful long-term outcomes. The outlook for patients has improved significantly in recent years with the establishment of diagnostic and classification criteria, better investigational modalities, and more effective medical and invasive therapy.","claims":[{"public_id":"cl_c8f975087b52d64fd692661b7843b1d9","status":"active","text":"An early prepulseless stage is often missed and is associated with nonspecific constitutional symptoms and elevated inflammatory markers.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_c8f975087b52d64fd692661b7843b1d9"},{"public_id":"cl_c11fcddd34b298c4039570fd19075d5b","status":"active","text":"Disease progression leads to a pulseless stage marked by missing pulses, vascular tenderness, ischemic symptoms, arterial wall thickening, stenotic or occlusive lesions, and aneurysm 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