{"corpus_id":25873818,"paper_sha":"fbb2c15ec1167ef0a1c813b71baec9e52fb2560f","doi":"10.1056/NEJM197806222982503","arxiv_id":null,"pmid":349387,"pmcid":null,"mag_id":2317792746,"dblp_id":null,"acl_id":null,"title":"Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning.","year":1978,"publication_date":"1978-06-22","venue":"New England Journal of Medicine","journal":{"name":"The New England journal of medicine","pages":"\n          1384-6\n        ","volume":"298 25"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Medicine"],"reference_count":29,"citation_count":803,"influential_citation_count":7,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Antigen-Antibody Reactions","mj":false,"ui":"D000937"},{"d":"Carcinoembryonic Antigen","mj":false,"qs":[{"q":"analysis","mj":true,"ui":"Q000032"}],"ui":"D002272"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Goats","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D006041"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Immunoglobulin G","mj":false,"ui":"D007074"},{"d":"Immunologic Techniques","mj":true,"ui":"D007158"},{"d":"Iodine Radioisotopes","mj":false,"ui":"D007457"},{"d":"Methods","mj":false,"ui":"D008722"},{"d":"Neoplasms","mj":false,"qs":[{"q":"diagnostic imaging","mj":true,"ui":"Q000000981"}],"ui":"D009369"},{"d":"Radionuclide Imaging","mj":false,"ui":"D011877"}],"chemicals":[{"n":"Carcinoembryonic Antigen","ui":"D002272","reg":"0"},{"n":"Immunoglobulin G","ui":"D007074","reg":"0"},{"n":"Iodine Radioisotopes","ui":"D007457","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"To determine whether tumors containing carcinoembryonic antigen could be detected by administration of a radiolabeled, affinity-purified, goat lgG having 70 per cent immunoreactivity against carcinoembryonic antigen, 18 patients with a history of cancer of diverse histopathology received an average total dose of 1.0 mCi of 131l-labeled lgG. Total-body photoscans were performed with a gamma scintillation camera at various intervals after administration of the radioactive antibody. Ordinary photoscans proved difficult to interpret because of blood-pool background radioactivity, thus necessitating the computer subtraction of radioactive blood-pool agents from the antibody's 131l activity. Tumor location could be demonstrated at 48 hours after injection in almost all cases studied. The scans were negative in patients without demonstrable tumors or with tumors apparently devoid of carcinoembryonic antigen. Circulating antigen levels of up to 350 ng per milliliter did not prevent successful tumor imaging after injection of the radioantibody.","claims":[{"public_id":"cl_8d5df2e37c3b3f39c342efc1945986da","status":"active","text":"Circulating antigen levels up to 350 ng per milliliter did not prevent successful tumor imaging after injection of the radioantibody.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8d5df2e37c3b3f39c342efc1945986da"},{"public_id":"cl_982e455bced973d7af9cfca4a22e20fa","status":"active","text":"Computer subtraction of radioactive blood-pool agents from the antibody's 131I activity was necessary because ordinary photoscans were difficult to interpret due to blood-pool background radioactivity.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_982e455bced973d7af9cfca4a22e20fa"},{"public_id":"cl_f3ac8b33ef388d6ea26e5992fe773117","status":"active","text":"Scans were negative in patients without demonstrable tumors or with tumors apparently devoid of carcinoembryonic antigen.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_f3ac8b33ef388d6ea26e5992fe773117"},{"public_id":"cl_7c3935d0e622c02dfcd96d968b45941e","status":"active","text":"Tumor location could be demonstrated by external photoscanning at 48 hours after injection in almost all studied cases.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_7c3935d0e622c02dfcd96d968b45941e"}],"concepts":[{"public_id":"co_123a406de6237aff2b3fd1ccf8cf48b6","status":"active","name":"external photoscanning","description":"An imaging method that uses a gamma scintillation camera to detect radiolabeled signals from within the body.","types":["imaging method"],"aliases":["photoscanning"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_123a406de6237aff2b3fd1ccf8cf48b6"},{"public_id":"co_351083aa32e495633cafdaa8d184e3ec","status":"active","name":"carcinoembryonic antigen","description":"A tumor-associated antigen targeted by the radiolabeled antibody in this imaging approach.","types":["antigen","biomarker"],"aliases":["CEA"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_351083aa32e495633cafdaa8d184e3ec"},{"public_id":"co_7bb0ea3000fb6a305df7c43d257185a9","status":"active","name":"computer subtraction","description":"A computational correction applied to remove blood-pool background from the antibody signal.","types":["data processing method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_7bb0ea3000fb6a305df7c43d257185a9"},{"public_id":"co_8d11dedf380e41b94b7e7b06ac11fe20","status":"active","name":"circulating antigen levels","description":"The concentration of antigen detected in the blood before or during imaging.","types":["measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8d11dedf380e41b94b7e7b06ac11fe20"},{"public_id":"co_93a65f3d153ec9b473404aedbdaec839","status":"active","name":"scans","description":"The photoscan images acquired after administration of the radiolabeled antibody.","types":["imaging result"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_93a65f3d153ec9b473404aedbdaec839"},{"public_id":"co_93e403e12e44f01b7b5d123c90bbb8cc","status":"active","name":"tumors","description":"Cancerous lesions present in the studied patients.","types":["disease entity"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_93e403e12e44f01b7b5d123c90bbb8cc"},{"public_id":"co_a6bb7cb37a76b07a3ffb6d71061f14f3","status":"active","name":"tumor imaging","description":"Imaging procedures used to visualize and localize tumors in the body.","types":["imaging outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a6bb7cb37a76b07a3ffb6d71061f14f3"},{"public_id":"co_c6c8289d096e25415f0532208ca45d91","status":"active","name":"blood-pool background radioactivity","description":"Radioactive signal in the bloodstream that interferes with interpretation of the scans.","types":["artifact","measurement interference"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c6c8289d096e25415f0532208ca45d91"},{"public_id":"co_d3614bb97e8dee30c29e6e1796582068","status":"active","name":"131I-labeled IgG","description":"An iodine-131 radiolabeled immunoglobulin G preparation used for tumor detection.","types":["radiopharmaceutical"],"aliases":["131I-labeled lgG"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d3614bb97e8dee30c29e6e1796582068"},{"public_id":"co_e9c56022e8b7f6b9e4906f478e94339d","status":"active","name":"radioantibody","description":"A radiolabeled antibody used to target specific antigens for imaging.","types":["imaging agent","antibody"],"aliases":["radiolabeled antibody"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e9c56022e8b7f6b9e4906f478e94339d"},{"public_id":"co_f91e905199072bc43c264365e3122c20","status":"active","name":"tumor location","description":"The anatomical site of a tumor as identified by imaging.","types":["imaging outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f91e905199072bc43c264365e3122c20"}],"external_ids":{"DOI":"10.1056/NEJM197806222982503","ArXiv":null,"PubMed":349387,"PubMedCentral":null,"MAG":2317792746,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/25873818","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":631044,"paper_uid":"3b5e462b-4b37-49cc-8e19-ea1923a0316c","canonical_identity":{"paper_id":631044,"paper_uid":"3b5e462b-4b37-49cc-8e19-ea1923a0316c","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/25873818"}